DNA Origami‐Based Nanoprinting for the Assembly of Plasmonic Nanostructures with Single‐Molecule Surface‐Enhanced Raman Scattering

Abstract

Metallic nanocube ensembles exhibit tunable localized surface plasmon resonance to induce the light manipulation at the subwavelength scale. Nevertheless, precisely control anisotropic metallic nanocube ensembles with relative spatial directionality remains a challenge. Here, we report a DNA origami based nanoprinting (DOBNP) strategy to transfer the essential DNA strands with predefined sequences and positions to the surface of the gold nanocubes (AuNCs). These DNA strands ensured the specific linkages between AuNCs and gold nanoparticles (AuNPs) that generating the stereo‐controlled AuNC‐AuNP nanostructures (AANs) with controlled geometry and composition. By anchoring the single dye molecule in hot spot regions, the dramatic enhanced electromagnetic field aroused stronger surface enhanced Raman scattering (SERS) signal amplification. Our approach opens the opportunity for the fabrication of stereo‐controlled metal nanostructures for designing highly sensitive photonic devices.

Few-Molecule Strong Coupling with Dimers of Plasmonic Nanoparticles Assembled on DNA

“…However, only 3% of studied dimers feature hybrid coupled modes, probably because of an uncontrolled orientation of the emitters’ transition dipoles with respect to the dimer axis and to the preferential positioning of emitters on facets of AuNPs, which reduces the coupling strength compared to perfect spheres and to emitters positioned on the tips of faceted AuNPs. Interestingly, DNA-based nanotechnology provides a flexible experimental toolbox to overcome these nanofabrication issues by controlling the orientation of the transition dipoles of dye molecules, by organizing anisotropic particles with sharp tips with an excellent control over their relative orientation, − or by functionalizing these sharp tips specifically . Such hybrid nanostructures are therefore excellent candidates to reach reproducible few- or single-molecule strong coupling at room temperature, in order to exploit the expected optical properties of these nanophotonic systems such as single-photon nonlinearities and ultrafast switching. ,,, …”

“…Interestingly, DNAbased nanotechnology provides a flexible experimental toolbox to overcome these nanofabrication issues by controlling the orientation of the transition dipoles of dye molecules, 68 by organizing anisotropic particles with sharp tips with an excellent control over their relative orientation, 69−71 or by functionalizing these sharp tips specifically. 72 Such hybrid nanostructures are therefore excellent candidates to reach reproducible few-or single-molecule strong coupling at room temperature, in order to exploit the expected optical properties of these nanophotonic systems such as single-photon nonlinearities and ultrafast switching. 4,5,7,8 METHODS Synthesis of DNA-Templated 40 nm AuNP Dimers.…”

Synthesis and Characterization of Hyper‐Branched Nanoparticles with Magnetic and Plasmonic Properties

“…In nanotechnologies, much attention is paid to metal nanosheets [9,10] and nanoparticles of various composition, shape and size for their use in catalysis, [11–17] biomedicine, [7,18–24] electronics [4,25,26] and optics [27,28] …”

Encoding Morphogenesis of Quasi‐Triangular Gold Nanoprisms with DNA

“…Typically, in the field of plasmonics, precise control of the shape and size of gold nanoparticles renders the tailoring of their plasmonic modes possible, [3] leading to a variety of novel applications, including metamaterials, sensing, catalysis, energy generation, and biomedicine [4–10] . However, up to date, most efforts have focused on well‐studied gold nanoparticles that can be easily synthesized and stabilized, such as gold nanospheres, nanoplates, nanorods, and nanocubes [11–14] . Anisotropic structures with well‐controlled morphologies mainly exist in transient states are still rarely studied, which greatly limits the insight into their rich plasmonic properties.…”