DNA origami characterized via a solid-state nanopore: insights into nanostructure dimensions, rigidity and yield

Abstract

Due to their programmability via specific base pairing, self-assembled DNA origami structures have proven to be useful for a wide variety of applications, including diagnostics, molecular computation, drug delivery, and...

A Universal Approximation for Conductance Blockade in Thin Nanopore Membranes

“…Long, rod-like, charged cylindrical objects such as dsDNA, filamentous viruses such as fd or TMV, nanorods, and DNA nanostructures such as DNA origami bundles, etc. (Figure d), have been studied extensively because of their importance in applications such as sequencing, diagnostics, and biophysical studies. ,,− In addition to the prevalence of such analytes, their cylindrical symmetry offers mathematical convenience for the use of cylindrical or oblate spheroidal coordinate systems in analytical conductance models. Relevant length scales for a system with cylindrical analytes including pore diameter D , membrane thickness L , and analyte diameter d are depicted in panels e and f of Figure .…”