DNA Origami Nanopores

Bell, Nicholas A. W.; Engst, Christian; Ablay, Marc; Divitini, Giorgio; Ducati, Caterina; Liedl, Tim; Keyser, Ulrich F.

doi:10.1021/nl204098n

Cited by 287 publications

(269 citation statements)

References 39 publications

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“…Such protein-graphene hybrids or DNA origami-graphene structures [122][123][124] could provide means to control the motion of DNA molecules. Yet another alternative is to use plasmonics to control a DNA molecule in a nanopore [125,126].…”

Section: Discussionmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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Fast, cheap, and reliable DNA sequencing could be one of the most disruptive innovations of this decade as it will pave the way for personalised medicine. In pursuit of such technology, a variety of nanotechnology-based approaches have been explored and established including sequencing with nanopores. Due to its unique structure and properties, graphene provides interesting opportunities for the development of a new sequencing technology. In recent years, a wide range of creative ideas for graphene sequencers have been theoretically proposed and the first experimental demonstrations have begun to appear. Here, we review the different approaches to using graphene nanodevices for DNA sequencing, which involve DNA passing through graphene nanopores, nanogaps, and nanoribbons, and the physisorption of DNA on graphene nanostructures. We discuss the advantages and problems of each of these key techniques, and provide a perspective on the use of graphene in future DNA sequencing technology.

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Section: Discussionmentioning

confidence: 99%

Graphene nanodevices for DNA sequencing

2016

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“…Such structures have been typically assembled by folding a long 'scaffold' strand of viral single-stranded DNA (ssDNA) using multiple short ssDNA 'staple' strands; however, they can also be assembled without the use of a scaffold [5][6][7] . The strength of this technique has been demonstrated in a number of applications including control and study of molecular transport in cells [8][9][10] , drug delivery systems 11 , as platforms for single-molecule chemical reactions 12,13 , rulers for super-resolution microscopy 14,15 as well as nanopore biosensors [16][17][18] . Furthermore, the double helical structure of DNA offers the possibility of unique binding sites with a regular spacing of B7 nm (21 bp) along the helix and B3 nm perpendicular to the helical axis 19 which makes DNA origami perfectly suited as a platform for the assembly of multicomponent nanostructures 20,21 .…”

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confidence: 99%

DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering

et al. 2014

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Plasmonic sensors are extremely promising candidates for label-free single-molecule analysis but require exquisite control over the physical arrangement of metallic nanostructures. Here we employ self-assembly based on the DNA origami technique for accurate positioning of individual gold nanoparticles. Our innovative design leads to strong plasmonic coupling between two 40 nm gold nanoparticles reproducibly held with gaps of 3.3±1 nm. This is confirmed through far field scattering measurements on individual dimers which reveal a significant red shift in the plasmonic resonance peaks, consistent with the high dielectric environment due to the surrounding DNA. We use surface-enhanced Raman scattering (SERS) to demonstrate local field enhancements of several orders of magnitude through detection of a small number of dye molecules as well as short single-stranded DNA oligonucleotides. This demonstrates that DNA origami is a powerful tool for the high-yield creation of SERS-active nanoparticle assemblies with reliable sub-5 nm gap sizes.

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Section: Functional Modification Of Smart Bioinspired Nanochannelsmentioning

confidence: 99%

“…The hybrid nanopores could be repeat edly assembled by reversing the applied potential. [40] Then, they created a glass nanocapillary/DNA origami system by voltage trapping a flat DNA origami structure onto a nano capillary (Figure 3b). This system is able to influence the folding of λ DNA by tuning the pore diameter of the DNA origami structure.…”

Section: Introductionmentioning

confidence: 99%

Smart Bioinspired Nanochannels and their Applications in Energy‐Conversion Systems

Fan

Liu

et al. 2017

Advanced Materials

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materials. For example, nanochannels fab ricated in elastic materials can respond to an applied pressure, [4] and conical nanochannels in poly(ethylene tereph thalate) (PET) membranes can respond to pH. [5] Thus, it is convenient to achieve simple responsive properties by directly using responsive materials to construct the nano channels. The second route is an indirect method, where functional molecules and materials are modified onto the inner surfaces of nanochannels. This method can change the physical and chemical properties of nanochannels to make the system more intelligent. [6] Smart bioinspired nano channels with different shapes and compositions have been fabri cated, and these nanochannels can respond to various stimuli, such as pH, [7] light, [8] temperature, [9] specific ions, [10] and mole cules. [11] Compared with their fragile biological counterparts, smart bioinspired nanochannels possess excellent mechanical robustness, controllable geometry, tunable surface properties, and good chemical stability. [12] These advantages make them useful for many potential applications, ranging from molecular filters to biosensors to energy conversion devices. [13] Smart bioinspired nanochannels not only provide a basic research platform to simulate the ion transport process in living bodies, but also boost the generation of energy conver sion devices. In nature, ion channels can be used as switches to regulate mass transport and energy conversion. Learning from nature, numerous energy conversion systems based on artificial ion channels have been devised, [14] which are of great significance for the development of sustainable energy. Here, we summarize recent advances in the fabrication of smart bioinspired nanochannels and highlight their applications in energy conversion systems. Recent Advances in the Fabrication of Smart Bioinspired Nanochannels Materials and TechniquesThe fragility and instability of biological ion channels have motivated the development of smart bioinspired nanochan nels. To satisfy specific application requirements, various materials such as biological, [15] inorganic, [16] organic, [17] and composite materials [18] have been used to fabricate artificial nanochannels. Currently, nanochannels with diverse shapes and structures can be obtained using different techniques and Smart bioinspired nanochannels exhibiting ion-transport properties similar to biological ion channels have attracted extensive attention. Like ion channels in nature, smart bioinspired nanochannels can respond to various stimuli, which lays a solid foundation for mass transport and energy conversion. Fundamental research into smart bioinspired nanochannels not only furthers understanding of life processes in living bodies, but also inspires researchers to construct smart nanodevices to meet the increasing demand for the use of renewable resources. Here, a brief summary of recent research progress regarding the design and preparation of smart bioinspired nanochannels is presented. Moreover, representative applications ...

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DNA Origami Nanopores

Cited by 287 publications

References 39 publications

Graphene nanodevices for DNA sequencing

Graphene nanodevices for DNA sequencing

DNA origami based assembly of gold nanoparticle dimers for surface-enhanced Raman scattering

Smart Bioinspired Nanochannels and their Applications in Energy‐Conversion Systems

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