DNA Origami Route for Nanophotonics

Kuzyk, Anton; Jungmann, Ralf; Acuna, Guillermo P.; Liu, Na

doi:10.1021/acsphotonics.7b01580

Cited by 190 publications

(196 citation statements)

References 230 publications

(501 reference statements)

Supporting

Mentioning

195

Contrasting

Unclassified

Order By: Relevance

“…DNA‐assembled plasmonic hot spots have already been employed to promote enhancement of fluorescence and Raman spectroscopy, and to obtain strong coupling between plasmons and excitons of J aggregates . Additionally, DNA self‐assembly is a versatile technique that can be extended to various plasmonic materials and different QEs, giving custom tunability over the optical properties of the assemblies . Importantly, this method enables a one‐pot fabrication of trillions of devices in parallel.…”

Section: Introductionmentioning

confidence: 99%

DNA‐Mediated Self‐Assembly of Plasmonic Antennas with a Single Quantum Dot in the Hot Spot

Nicoli

Zhang

Hübner

et al. 2019

Small

View full text Add to dashboard Cite

DNA self‐assembly is a powerful tool to arrange optically active components with high accuracy in a large parallel manner. A facile approach to assemble plasmonic antennas consisting of two metallic nanoparticles (40 nm) with a single colloidal quantum dot positioned at the hot spot is presented here. The design approach is based on DNA complementarity, stoichiometry, and steric hindrance principles. Since no intermediate molecules other than short DNA strands are required, the structures possess a very small gap (≈ 5 nm) which is desired to achieve high Purcell factors and plasmonic enhancement. As a proof‐of‐concept, the fluorescence emission from antennas assembled with both conventional and ultrasmooth spherical gold particles is measured. An increase in fluorescence is obtained, up to ≈30‐fold, compared to quantum dots without antenna.

show abstract

Section: Introductionmentioning

confidence: 99%

DNA‐Mediated Self‐Assembly of Plasmonic Antennas with a Single Quantum Dot in the Hot Spot

Nicoli

Zhang

Hübner

et al. 2019

Small

View full text Add to dashboard Cite

show abstract

“…[2][3][4][5] In recenty ears, programmable DNA origami nanostructures (DONs) [6][7][8][9][10] have been considered promising candidates for the development of tailored and multifunctional drug-delivery vehicles. However, in many of those applicationsa nd most notably in drug delivery,t heir stability and function may be compromised by the biological media.…”

mentioning

confidence: 99%

“…[2][3][4][5] In recenty ears, programmable DNA origami nanostructures (DONs) [6][7][8][9][10] have been considered promising candidates for the development of tailored and multifunctional drug-delivery vehicles. [2][3][4][5] In recenty ears, programmable DNA origami nanostructures (DONs) [6][7][8][9][10] have been considered promising candidates for the development of tailored and multifunctional drug-delivery vehicles.…”

mentioning

confidence: 99%

Real‐Time Observation of Superstructure‐Dependent DNA Origami Digestion by DNase I Using High‐Speed Atomic Force Microscopy

et al. 2019

View full text Add to dashboard Cite

GuidoG rundmeier, [a] AdrianK eller,* [a] andV eikkoL inko* [a, b, c] DNA nanostructures have emerged as intriguing tools for numerous biomedical applications. However, in many of those applicationsa nd most notably in drug delivery,t heir stability and function may be compromised by the biological media. A particularly important issue for medicala pplications is their interaction with proteins such as endonucleases, which may degrade the well-defined nanoscale shapes.H erein, fundamental insights into this interaction are provided by monitoring DNase Id igestion of four structurally distinct DNA origami nanostructures (DONs) in real time and at as ingle-structure level by using high-speed atomic force microscopy.T he effect of the solid-liquidi nterface on DON digestioni sa lso assessed by comparison with experiments in bulk solution. It is shown that DON digestion is strongly dependentoni ts superstructure and flexibility and on the local topology of the individual structure.The rapidly evolvingf ield of DNA nanotechnology enables custom fabrication of various nanoscale shapes with unprecedented addressability; [1] these have found some fascinating implementations in materials science and especiallyi nm any biochemicala nd biophysical systems. [2][3][4][5] In recenty ears, programmable DNA origami nanostructures (DONs) [6][7][8][9][10] have been considered promising candidates for the development of tailored and multifunctional drug-delivery vehicles. [11][12][13][14] For therapeutic in vivo applications, the DON vehicles should preferably be compatible with the immunes ystem, resistant to nucleases, have as ufficiently long circulation half-life, and be able to maintain their shape at the ionic strengths of the biological fluids. [15] However,c oncerns have been raised regarding the stabilityo fD ONs and their performance in biological media. [16, 17] Although it has been shown that DONs can survive under low-cation conditions, [18,19] stability studies performedi n serum or cell culture media have yielded somewhat controversial and quite distinct results. [8,15,[19][20][21] Therefore, significant efforts have been madei nto coating ands tabilizing DONs under biologically relevant conditions. [17,[22][23][24][25] Herein, we study DON digestion by endonucleases (DNase I) in dependence of DON superstructure. DNase Ii sw idely present in serum and varioust issues,w hich makes it one of the most relevantt hreatst ot he stability of DONs in vivo. Previously,D ON cleavage by endonucleases was studied by employing ratherl ong timescales. [8,16] Therefore, thesea pproaches can only resolve the time points at which the whole or most of the nanostructure has been digested. Moreover,t hese experiments could neither reveals patial variations of DNase Is usceptibility within as ingle DON, nor facilitate parallel comparison of different structures under the same conditions. Herein, we thus employ high-speed atomicf orce microscopy (HS-AFM) [26] to study the degradation of four well-established and structurally disti...

show abstract

“…Over the last decade, growing interest has been reported in patterning DNA origami‐assembled metallic nanoparticles for the construction of complex nanoelectronics and optical devices, due to their unique optical properties such as Fano resonances, chirality, surface‐enhanced Raman, and fluorescence enhancement . The assembly of metallic nanoparticles relies on the functionalization of metal nanoparticles with thiol‐modified single‐stranded DNA as linkers.…”

Section: Fabrication Of Nanoscale Patterns On Dna Origamimentioning

confidence: 99%

“…Plasmonic metamaterials are artificial systems that produce unique optical properties due to the precise arrangement of nanoscale metallic building blocks. The interaction of light with metallic nanoparticles results in localized surface plasmon resonances, which can be coupled if these NPs are in close proximity. Such coupling is sensitive to the distance between the NPs, as well as arrangement of NPs in space.…”

Section: Fabrication Of Dynamic Patterns On Dna Origamimentioning

confidence: 99%

Create Nanoscale Patterns with DNA Origami

Fan

Wang

Kenaan

et al. 2019

Small

View full text Add to dashboard Cite

Structural deoxyribonucleic acid (DNA) nanotechnology offers a robust platform for diverse nanoscale shapes that can be used in various applications. Among a wide variety of DNA assembly strategies, DNA origami is the most robust one in constructing custom nanoshapes and exquisite patterns. In this account, the static structural and functional patterns assembled on DNA origami are reviewed, as well as the reconfigurable assembled architectures regulated through dynamic DNA nanotechnology. The fast progress of dynamic DNA origami nanotechnology facilitates the construction of reconfigurable patterns, which can further be used in many applications such as optical/plasmonic sensors, nanophotonic devices, and nanorobotics for numerous different tasks.

show abstract

DNA Origami Route for Nanophotonics

Cited by 190 publications

References 230 publications

DNA‐Mediated Self‐Assembly of Plasmonic Antennas with a Single Quantum Dot in the Hot Spot

DNA‐Mediated Self‐Assembly of Plasmonic Antennas with a Single Quantum Dot in the Hot Spot

Real‐Time Observation of Superstructure‐Dependent DNA Origami Digestion by DNase I Using High‐Speed Atomic Force Microscopy

Create Nanoscale Patterns with DNA Origami

Contact Info

Product

Resources

About