DNA polymorphisms defined by the Tu108 probe map to theTla region of mouse chromosome 17

Gasser, David L.; Yadvish, Karen N.; Feinstein, Paul; Passmore, Howard C.

doi:10.1007/bf02399414

Biochem Genet

1988

DOI: 10.1007/bf02399414

|View full text |Cite

DNA polymorphisms defined by the Tu108 probe map to theTla region of mouse chromosome 17

David L. Gasser

Karen N. Yadvish

Paul Feinstein

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1989

2001

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, RFLPs in animals, like biochemical and immunological marker genes, are useful as markers in studies on animal genetics (Paul and Elliot, 1987;Cobb et al, 1987;Gasser et al, 1988). Most known RFLPs result from single-base substitutions that create or destroy a cleavage site for a specific restriction endonuclease causing a change in the length of a DNA fragment.…”

mentioning

confidence: 98%

Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats

et al. 1989

View full text Add to dashboard Cite

A novel restriction fragment length polymorphism in inbred rats was detected by Southern blot analysis with rat growth hormone cDNA as a probe. Four alleles, characterized by PstI fragments of 1.2, 1.1, 0.9, and 0.7 kb, respectively, were detected in 27 strains examined. The same distribution of polymorphisms was observed on digestion of DNAs of these strains with three other enzymes, PvuII, HindIII, and BamHI. Moreover, the same differences in length of allelic restriction fragments were obtained with these restriction enzymes as with PstI. These findings suggested that the polymorphism was caused by insertion or deletion of variable DNA segments in the second intron of the growth hormone gene. Linkage analyses using backcross progeny provided no evidence for close linkage between the restriction fragment length polymorphism locus and 10 other loci examined.

show abstract

mentioning

confidence: 98%

Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats

et al. 1989

View full text Add to dashboard Cite

show abstract

Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats

et al. 1989

View full text Add to dashboard Cite

The problem of the lacuna posited in Beowulfat 11.389b-90a has recently been reopened by Kevin Kiernan. The lines, as they stand in Klaeber's edition (I include the two preceding half-lines to complete thesence), are as follows: "gesaga him eat wordum, bzt hie sint wilcuman Deniga leodum." [ba to dura eode widcuir hale&] word inne abead: (11.388-90)' The immediate context is Hrothgar's welcoming of Beowulf. Hrothgar has just ordered Wulfgar to bring the Geats in and to bid them welcome, and here Wulfgar begins to execute those orders. Editors have generally dealt with this oassaae much as does Klaeber here above. They postulate a lacuna of two half-lines and till it-with narrative which identities Wulfgar as the sneaker and gets him from Hrothaar to the door.2 Kieman. on the other hand. arguing that defective alliteration is not sufficient grounds for the conjectural restoration of supposedly missing text,3 would allow the manuscript reading to stand. An examination of the passage from the perspective of direct speech, however, suggests that neither approach fully addresses all the points at issue here. There are no physical grounds for postulating a lacuna: Deniga leodum is followed immediately in the manuscript by word inne abead. Kieman suggests that the manuscript reading can be made to make sense simply by placing closing quotation marks after Deniga leodum and opening quotation marks after word inne abead. With this punctuation, Deniga leodum remains, as has been traditional, part of Hrothgar's speech ("Tell them also with words that they are welcome to the people of the Danes"), and word inne ubeadbecomes the introduction to Wulfgar's speech, with the understood third person pronoun of ubead identifying the speaker ("He announced the words within"). The problem with the passage is not simply a matter of alliteration, however. The manuscript reading, even with the question of alliteration set aside, is so much at odds with the poet's treatment of direct speech elsewhere in the poem that emendation still seems justified. Under the poet's normal practices, both the identity ofa speaker and the location from which he speaks are adequately accounted for. These points, previous emendations have adressed. However, in this poem direct speech invariably terminates with the full poetic line. What has not hitherto been taken into account in any treatment of the passage is the anomalous ending of Hrothgar's speech, and the consequent likelihood that part of the lost material came not from the narrative but from that speech. The Beowulf-poet is, by and large, remarkably careful in matters pertaining to direct speech. As a rule, speakers are explicitly identified, whether by proper name, descriptive phrase, or epithet. Beowulf, in the early speech exchanges, is variously se yldesta (1. 258a), wisa werodes (1.259a), ellenrof(substantive, 1.340a), and w&c Wederu leod(1.34 la), as well as "Beowulf," and Wulfgar himself appears twice under his own name (11. 348a and 360a) and once as the wlonc h&e d (1.33 1 b). In fact, onl...

show abstract

Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region

et al. 2001

View full text Add to dashboard Cite

Susceptibility to chemically induced lung tumorigenesis has previously been mapped to a genomic interval of 27 kb in the MHC class III region of the mouse using two H2 (a/b) intra- H2 recombinants, B10.A(1R) and B10.A(2R). Three genes are located within this interval, G7e (encoding a viral envelope protein), G7a/ Vars2 (encoding valyl-tRNA synthetase), and G7c (a gene with unknown function). A 70 kb contig, spanning the 27 kb region and extending 20 kb either side, was constructed from lambda phage libraries with genomic inserts derived from mouse strains B10.A(1R) and B10.A(2R). The region was analyzed for single-nucleotide polymorphisms, which would facilitate further fine mapping of the interval. Analysis of the expression levels of the candidate genes did not reveal any difference between B10.A(1R) and B10.A(2R). In addition, no differences were found at the sequence level in the 27 kb interval except for an A to T transition in intron 7 of G7c. A database comparison of the sequence surrounding this polymorphism did not identify any DNA-binding or enhancer consensus sequence. In conclusion, the previously observed phenotype could not be associated with or assigned to any of the candidate genes G7e, G7a/ Vars2, or G7c, nor could any of the other susceptibility loci, which have been reported to map to this region ( Cps1, Acp, Orch1, and Igis1).

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

DNA polymorphisms defined by the Tu108 probe map to theTla region of mouse chromosome 17

Cited by 3 publications

References 17 publications

Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats

Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats

Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats

Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region

Contact Info

Product

Resources

About