DNA polymorphisms in the apolipoprotein C-III and insulin genes and atherosclerosis

Rees, A.; Stocks, J.; Williams, Larry G.; Caplin, JL; Jowett, N. I.; Aj, Camm; Galton, D. J.

doi:10.1016/0021-9150(85)90072-3

Cited by 71 publications

(23 citation statements)

References 14 publications

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“…hypertriglyceridaemia [37] or atherosclerosis [38]. However, data for this has also proved controversial [39]. In this study, no association was seen of atherosderosis (ischaemic heart disease and/or peripheral vascular disease) or hyperlipidaemia with the Class 3 allele in all disease groups (Table 3 B).…”

Section: Discussioncontrasting

confidence: 49%

The genetic predisposition to fibrocalculous pancreatic diabetes

et al. 1989

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Summary. Fibrocalculous pancreatic diabetes (previously known as tropical pancreatic diabetes) is a rare cause of diabetes confined to countries within the tropical belt. The aetiology of fibrocalculous pancreatic diabetes is thought to be environmental although the agent(s) is unknown. We have investigated a possible genetic basis of this disease by looking for restriction fragment length polymorphisms of genes implicated in the aetiology of diabetes rnellitus. Seventy-six Dravidian patients with fibrocalculous pancreatic diabetes were studied, and the restriction fragment length polymorphisms obtained compared to racially matched control subjects (n=94), patients with Type2 (non-insulin-dependent) diabetes (n=87) and Type 1 (insulin-dependent) diabetes (n = 58). No association of fibrocalculous pancreatic diabetes was found with restriction fragment length polymorphisms of the insulin receptor gene. Although no association of fibrocalculous pancreatic diabetes was found with polymorphism of the HLA DRc~/DQc~/DXct genes, an association was found with the Taq 1 restriction fragment length polymorphisms of the DQ[~ gene (DQ[~ T2/T6 present in 39% of patients with fibrocalculous pancreatic diabetes compared to 19% in control subjects; p = 0.01 ; corrected p value = 0.04) which is similar to that found in Type 1 but not Type 2 diabetes. An association of fibrocalculous pancreatic diabetes was also found with the hypervariable region in the 5-prime flanking region of the insulin gene; 40% of patients possessed the class 3 allele compared to 9.5% of control subjects p = 0.0001 ; corrected p value = 0.0008). In Type 2 diabetes, similar results were obtained with 33% subjects possessing the class 3 allele (t7 value compared to control subjects = 0.0005; corrected p value = 0.004). This study suggests that fibrocalculous pancreatic diabetes has a genetic component in its aetiology. Furthermore, its origin might be related to an individual with part of the genetic predisposition to diabetes (Type 1 or Type 2) who additionally has evidence of chronic calcific pancreatitis.

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Section: Discussioncontrasting

confidence: 49%

The genetic predisposition to fibrocalculous pancreatic diabetes

et al. 1989

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“…A summary of their data is presented in Table 3 together with our data. Both the $2 and M2 alleles are uncommon in healthy Caucasians and the $2 allele has been reported to be associated with coronary atherosclerosis at least in local Caucasian populations (Ferns et al, 1985;Rees et aL, 1985;Ferns and Galton, I986;Deeb et al, 1986;Acton et al, 1986). The results of the present study indicate that both the $2 and M2 alleles are common in healthy Japanese.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein AI-CIII gene polymorphisms in a Japanese population

et al. 1986

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SummaryApolipoprotein (apo) CIII Sst-I genotypes and apo AI Msp-I genotypes were investigated in 82 unrelated healthy Japanese, using genomic hybridization analysis with a 2.2 kb fragment of the human apo AI gene. The frequencies of the $2 and M2 alleles were 0.34 and 0.40, respectively, and much higher than those in Caucasians. The alleles identified by the apo CIII Sst-I and apo AI Msp-I polymorphisms were observed to be in linkage disequilibrium (A=0.206+0.012, p<0.001). Three of the four possible haplotypes were identified: the frequencies of the haplotype were S1-M1=0.604, $2-M2=0.341, and S1-M2=0.055. The data indicate that Japanese are characterized by the common presence of the haplotype $2-M2 as compared with Caucasians and that the haplotypes identified by the apo CIII Sst-I and apo AI Msp-I polymorphisms are useful genetic markers for Japanese.

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“…Most of these studies found a relationship between the presence of $2 allele and hypertriglyceridemia (2)(3)(4)(5)(6)9,11,(13)(14)(15)(16)18,(20)(21)(22). An association of this allele with CAD was also reported (26)(27)(28). PauI-Hayase et al (29) conducted a study on the Sstl polymorphism on Asian Indians residing at U. K. ($2=0.19).…”

Section: ) Genotypic Distribution Was In Agreement Withmentioning

confidence: 99%

Study of apolipoproteinc3 Sstl polymorphism in healthy volunteers from Northern India

Chhabra

Agarwal²,

Vasisht

et al. 2003

Indian J Clin Biochem

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Several studies including a small case-control (hypertriglyceridemic / normotriglyceridemic individuals) study by us revealed close association between rare $2 allele of APOC3 Sstl polymorphism and hypertriglyceddemia. With the understanding that Asian Indians are highly vulnerable to the adverse effects of hypertdglyceridemia, we extended the investigation and studied the frequency distribution of this polymorphism in 216 healthy volunteers from Northern plains of India. We found that more than 50% of the study population had one ortwo $2 allele. This may suggest that a larger fraction of this population is genetically predisposed to hypertdglyceddemia.

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DNA polymorphisms in the apolipoprotein C-III and insulin genes and atherosclerosis

Cited by 71 publications

References 14 publications

The genetic predisposition to fibrocalculous pancreatic diabetes

The genetic predisposition to fibrocalculous pancreatic diabetes

Apolipoprotein AI-CIII gene polymorphisms in a Japanese population

Study of apolipoproteinc3 Sstl polymorphism in healthy volunteers from Northern India

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