“…PRIM1, as a new oncogene, was first found to be amplified in osteosarcoma [25] . At present, increasing evidence has shown that PRIM1 acts as an oncogene that enhances the aggressive behaviors of cancer cells, including cervical cancer [26] , hepatocellular carcinoma [27] , and colorectal cancer [28] , similar to our results. In breast cancer, silencing PRIM1 inhibits cell cycle progression and DNA damage by inactivating the G2/M cell cycle checkpoint [5] .…”