DNA-protein interactions in the CCAAT box region of the murine lactate dehydrogenase C promoter

Ambhaikar, Madhavee; Goldberg, Erwin

doi:10.1002/(sici)1098-2795(199904)52:4<360::aid-mrd4>3.0.co;2-i

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…5), a feature characteristic of "atypical" housekeeping genes that show a low level of basal expression but are regulated by different extracellular factors, including cytokines. This feature of UGDH promoter is distinct from other sugar or alcohol dehydrogenases (51), including the enzymes of the glycolytic pathway (52,53). The UGDH core promoter contains twelve Sp1 consensus sequences.…”

Section: Basal Expression Of Ugdh Mrna Effects Of Tgf-␤ Andmentioning

confidence: 97%

Specific Protein-1 Is a Universal Regulator of UDP-glucose Dehydrogenase Expression

Bontemps

Vuillermoz

Antonicelli

et al. 2003

Journal of Biological Chemistry

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Section: Basal Expression Of Ugdh Mrna Effects Of Tgf-␤ Andmentioning

confidence: 97%

Specific Protein-1 Is a Universal Regulator of UDP-glucose Dehydrogenase Expression

Bontemps

Vuillermoz

Antonicelli

et al. 2003

Journal of Biological Chemistry

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“…Two known exceptions are the kidney and particularly the heart, were the LDH-B is the predominant isoform [Markert et al, 1975;Markert, 1984;Li et al, 1983;Thomas et al, 1990;Jungmann et al, 1998]. In birds and reptiles LDH-A and LDH-B are the only isoforms reported [Stock et al, 1997;Mannen et al, 1997], however in mammals and columbid birds, a testis specific isoform, LDH-C has been characterized [Burgos et al, 1995;Cooker et al, 1993, Bradley et al, 1996Ambhaikar and Goldberg 1999]. During chicken spermatogenesis both LDH-A and LDH-B are expressed in meiotic and premeiotic cells, but only the LDH-B transcript persists in elongated spermatids until the end of spermiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Expression of lactate dehydrogenases A and B during chicken spermatogenesis: Characterization of testis specific transcripts

Arias

Mezquita

2000

J. Cell. Biochem.

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The substrates required for glycolysis change markedly at successive stages of spermatogenesis suggesting a considerable plasticity in the expression of glycolytic enzymes. Lactate dehydrogenase (LDH) isoenzymes, LDH-A and LDH-B, are expressed in premeiotic, meiotic cells, and early spermatids, both in avian and mammalian spermatogenesis. Highly polyadenylated forms, particularly of LDH-A, were detected in chicken testis. While mammals and columbid birds express the testis specific LDH-C gene in meiotic and postmeiotic cells, several LDH-B testis specific transcripts were detected in the corresponding cells during chicken spermatogenesis. These testis specific transcripts and the mRNA of mammalian LDH-C show several properties in common, such as temporal correlation of expression, mRNA stability, and repression of premature translation. These observations suggest that the testis specific transcripts could perform during chicken spermatogenesis the functions of the LDH-C mRNA in mammalian testis.

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Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint

et al. 2003

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Sequences complementary to the X-linked ubiquitin-specific protease gene Usp9x (Dffrx) have been shown to map to the Sxr(b) interval of the mouse Y Chromosome (chr) and to be expressed in a testis-specific manner. In humans, ubiquitously expressed functional homologues (USP9Y and USP9X DFFRY/DFFRX) are present on both sex chromosomes, whereas in mouse it remains to be demonstrated that the Y-linked sequences encode a functional protein. In this paper, it is shown that the Usp9y gene encodes a potentially functional ubiquitin-specific protease possessing a core promoter region that shares several features characteristic of other testis-specific genes. Analysis of synonymous and nonsynonymous nucleotide changes suggests that there is constraint on the amino acid sequence of both the mouse Usp9x and Usp9y genes, a finding that mirrors similar analysis of the human orthologs. Thus, in both mouse and human, selection is acting to maintain the amino acid sequence of the X and Y-linked genes. This indicates that in both species the genes on each sex chromosome continue to encode an important function.

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DNA-protein interactions in the CCAAT box region of the murine lactate dehydrogenase C promoter

Cited by 4 publications

References 34 publications

Specific Protein-1 Is a Universal Regulator of UDP-glucose Dehydrogenase Expression

Specific Protein-1 Is a Universal Regulator of UDP-glucose Dehydrogenase Expression

Expression of lactate dehydrogenases A and B during chicken spermatogenesis: Characterization of testis specific transcripts

Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint

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