DNA repair and metabolic gene polymorphisms affect genetic damage due to diesel engine exhaust exposure

León-Mejía, Grethel; Quintana-Sosa, Milton; Hernandez, Yurina de Moya; Rodríguez, Ibeth Luna; Trindade, Cristiano; Romero, Marco Anaya; Luna-Carrascal, Jaime; Ortíz, Ludis Oliveros; Acosta-Hoyos, Antonio; Benitez, Martha Lucia Ruiz; Valencia, Karen Franco; Rohr, Paula; Silva, Juliana da; Henriques, João Antônio Pêgas

doi:10.1007/s11356-020-08533-6

Cited by 8 publications

(2 citation statements)

References 70 publications

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“…The rs861539(C>T) polymorphism is a nonsynonymous substitution (C→T) resulting in an amino acid change from threonine to methionine at position 241 (Thr241Met) [26,27] . In the past decade, Numerous studies have investigated the potential biological signi cance of the XRCC-3 rs861539(Thr241Met) [28][29][30][31] , and it has been implicated as a causative risk factor for the development of different types of malignancies. The malignancy types included breast cancer [7,32,33] , lung cancer [34] , osteosarcoma [35] , melanoma [36] , thyroid cancer [14,16] .…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

Ren

Cao

et al. 2021

Preprint

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Objective To explore the association between single nucleotide polymorphism (SNP) in the XRCC3 rs861539(Thr241Met) locus and thyroid cancer risk. Methods Studies investigating the association between SNP in the XRCC3 gene and thyroid cancer susceptibility were retrieved from the PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), WanFang, and CBM (China Biology Medicine) databases. Eligible studies were screened according to inclusion/exclusion criteria and principles of quality evaluation. Meta-analysis was performed using Stata 14.0 software. Odds ratios with their corresponding 95% confidence intervals were pooled to assess the association between SNP in the XRCC3 gene rs861539 locus and thyroid cancer susceptibility. Results 10 articles(11 studies) were eligible for this meta-analysis. Meta-analysis results were shown as follows: No significant association was found between XRCC3 rs861539 polymorphism and thyroid cancer risk in Dominant and Overdominant models〔Dominant model: CT+TT vs CC, OR=1.231, 95% CI(0.998, 1.474); Overdominant model: CT vs TT+CC, OR=1.05, 95% CI(0.94, 1.18)〕. Significant associations were found in Recessive and Allelic models〔Recessive model: TT vs CC+CT, OR=1.632, 95% CI(1.349, 1.974); Allelic model: T vs C: OR=1.263, 95% CI(1.091, 1.462)〕. Conclusion The results of this study suggest that the XRCC3 rs861539(Thr241Met) polymorphism may be associated with an increased thyroid cancer risk in overall population, and a tendency for significantly increased thyroid cancer risk in TT(Met/Met) genotype population.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

Ren

Cao

et al. 2021

Preprint

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“…Diesel exhaust particles (DEPs) are generated from the incomplete combustion of diesel fuel, being able to cause oxidative DNA damage, which is associated with polymorphisms that confer deficiencies in DNA repair and/or xenobiotic metabolic pathways in white blood cells [129]. In addition to DNA damage, these NPs can modify the methylation profile, which plays an important role in the reprogramming of gene expression.…”

Section: Nanoparticle Pollutionmentioning

confidence: 99%

Cellular Alterations Due to Direct and Indirect Interaction of Nanomaterials with Nucleic Acids

Encinas-Gimenez,

Martin-Duque,

Martín-Pardillos

2024

IJMS

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Deoxyribonucleic acid (DNA) represents the main reservoir of genetic information in the cells, which is why it is protected in the nucleus. Entry into the nucleus is, in general, difficult, as the nuclear membrane is a selective barrier to molecules longer than 40 kDa. However, in some cases, the size of certain nanoparticles (NPs) allows their internalization into the nucleus, thus causing a direct effect on the DNA structure. NPs can also induce indirect effects on DNA through reactive oxygen species (ROS) generation. In this context, nanomaterials are emerging as a disruptive tool for the development of novel therapies in a broad range of biomedical fields; although their effect on cell viability is commonly studied, further interactions with DNA or indirect alterations triggered by the internalization of these materials are not always clarified, since the small size of these materials makes them perfectly suitable for interaction with subcellular structures, such as the nucleus. In this context, and using as a reference the predicted interactions presented in a computational model, we describe and discuss the observed direct and indirect effects of the implicated nanomaterials on DNA.

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The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review

Guedes Pinto,

Dias,

Renno

et al. 2024

Arch Toxicol

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DNA repair and metabolic gene polymorphisms affect genetic damage due to diesel engine exhaust exposure

Cited by 8 publications

References 70 publications

WITHDRAWN: Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

WITHDRAWN: Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

Cellular Alterations Due to Direct and Indirect Interaction of Nanomaterials with Nucleic Acids

The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review

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