DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

Long, Xi-Dai; Yao, Jin-Guang; Zeng, Zhi; Huang, Pinhu Liao Cen-Han; Huang, Zan-Song; Huang, Yongzhi; Ban, Fu-Zhi; Huang, Xiao-Yin; Yao, Limin; Fan, Lu-Dan; Fu, Guo‐Hui

doi:10.5772/20792

Cited by 16 publications

(33 citation statements)

References 122 publications

(156 reference statements)

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“…In the past 40 years, the total mortality rate of HCC gradually increased and followed by gradually decreased (Figure 1B), regardless of male or female population. Furthermore, this trend was not only associated with age but also more noticeable in male population than female population (Figure 2), possibly because male individuals featured more AFB1 exposure [4]. Supporting above-mentioned hypothesis, molecular epidemiological studies from high AFB1-exposure areas of Guangxi have exhibited that these individuals featuring more AFB1 exposure would face decreasing 5-year survival rate and increasing death risk [12][13][14].…”

Section: Epidemiology Of Afb1-related Hcc Among Guangxi Areasmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

“…Several previous reviews have signiicantly summarized the toxicology of AFB1 [3][4][5]15]. Generally, AFB1, an important mycotoxin and a category I known human carcinogen produced by Aspergillus parasiticus and Aspergillus lavus [4,5], has been found as toxic contaminants of human food such as ground nuts and core in tropical areas as a result of fungal contamination during growth and after harvest which under hot and humid conditions [15].…”

Section: Dna Damage Induced Byafb1 and Dna Repairmentioning

confidence: 99%

“…However, accumulating epidemiological evidence has shown that although many people are exposed to this risk factor, only a relatively small proportion of people with chronic AFB1 exposure develop HCC [3,4]. This suggests that an individual susceptibility related to genetic factors including genetic single nucleotide polymorphisms (GSNPs) in DNA repair genes might be correlated with HCC tumorigenesis [3][4][5]. In past several decade years, evidence has been accumulated to support the hypothesis that GSNPs in DNA repair genes may be of importance in determining individual susceptibility to AFB1-related HCC [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…This malignancy occurs more often in some hot and humid areas such as Guangxi area, mainly because of high alatoxin B1(AFB1) exposure [3,4]. However, accumulating epidemiological evidence has shown that although many people are exposed to this risk factor, only a relatively small proportion of people with chronic AFB1 exposure develop HCC [3,4]. This suggests that an individual susceptibility related to genetic factors including genetic single nucleotide polymorphisms (GSNPs) in DNA repair genes might be correlated with HCC tumorigenesis [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Wu¹,

Xi²,

Lü³

et al. 2017

Genetic Polymorphisms

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Alatoxin B1 (AFB1) is an important environmental carcinogen for the development of hepatocellular carcinoma (HCC). HCC is a complex disease likely resulting from genetic single nucleotide polymorphisms (GSNPs) of multiple interacting genes and geneenvironment interactions. Recent eforts have been made to analyze the associations between risk of this malignancy and GSNPs in genes involved in the repair of DNA damage induced by AFB1. Here, we reviewed the results of published case-control studies that have examined the efects of common alleles of all susceptible DNA repair genes, including XRCC1, XRCC3, XRCC4, XRCC7, XPC, and XPD, on risk of AFB1-related HCC among Guangxi population. Statistically signiicant diferences in genotype frequencies found in case-control comparisons were rs25487, rs80309960, rs861539, rs7003908, rs28383151, rs3734091, rs13181, and rs2228001 polymorphism. The overall efects of these GNSPs were moderate in terms of relative risk, with ORs ranging from 2 to 10. Furthermore, some evidence of the interaction of GSNPs in DNA repair genes and AFB1 exposure modulate risk of this cancer was also found, although the results require conirmation with larger sample size studies.

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Section: Epidemiology Of Afb1-related Hcc Among Guangxi Areasmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Section: Dna Damage Induced Byafb1 and Dna Repairmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Wu¹,

Xi²,

Lü³

et al. 2017

Genetic Polymorphisms

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Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma

et al. 2013

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Micro RNA‐4651 Serves as a Potential Biomarker for Prognosis When Selecting Hepatocellular Carcinoma Patients for Postoperative Adjuvant Transarterial Chemoembolization Therapy

Zhang

Huang

et al. 2018

Hepatology Communications

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Our previous reports have shown that microRNA‐4651 is a potential early diagnostic and prognostic marker for hepatocellular carcinoma. We aimed to investigate whether microRNA‐4651 modified postoperative adjuvant transarterial chemoembolization (pa‐TACE) to improve the prognosis of hepatocellular carcinoma. A hospital‐based retrospective study, including 302 patients with advanced‐stage hepatocellular carcinoma who received tumor resection or tumor resection plus pa‐TACE as an initial therapy, was conducted to assess the effects of microRNA‐4651 on pa‐TACE treatment. MicroRNA‐4651 expression in tumor tissues was tested using the TaqMan‐PCR technique. The sensitivity of tumor cells to doxorubicin (an anticancer drug used in pa‐TACE procedure) was analyzed by the half‐maximal inhibitory concentration (IC50). Upregulated microRNA‐4651 expression in tumor tissues can improve the therapeutic response of patients with hepatocellular carcinoma on pa‐TACE (hazard ratios [95% confidence intervals] = 0.32 [0.22‐0.46] for death risk and 0.39 [0.28‐0.56] for tumor‐recurrence risk, respectively), but downregulated expression cannot. Functional analyses–displayed microRNA‐4651 mimics decreased while its inhibitor increased the IC50 of tumor cells to doxorubicin (0.65 [0.61‐0.69] versus 2.17 [1.98‐2.37] µM). Cytochrome P450 2W1 was shown as a possible target of microRNA‐4651. Additionally, dysregulation of microRNA‐4651 also affected the clinical pathological features of hepatocellular carcinoma and was an independent prognostic factor for this cancer. Conclusion: These results indicate that increasing microRNA‐4651 expression may be beneficial for pa‐TACE in improving hepatocellular carcinoma prognosis.

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DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

Cited by 16 publications

References 122 publications

Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma

Micro RNA‐4651 Serves as a Potential Biomarker for Prognosis When Selecting Hepatocellular Carcinoma Patients for Postoperative Adjuvant Transarterial Chemoembolization Therapy

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