DNA Repair Gene ERCC1 and XPD Polymorphisms Predict Glioma Susceptibility and Prognosis

Chen, Daqing; Yao, Dongxiao; Zhao, Hongyang; Yang, Shujuan

doi:10.7314/apjcp.2012.13.6.2791

Cited by 31 publications

(26 citation statements)

References 29 publications

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“…A total of 12 studies met the inclusion criteria and were selected for analysis (Chen et al, 2000;Caggana et al, 2001;Yang et al, 2005;Wrensch et al, 2005;Liu et al, 2009;McKean-Cowdin et al, 2009;Rajaraman et al, 2010;Chen et al, 2012;Zhang et al, 2012;Luo et al, 2013;Pan et al, 2013;Dong et al, 2014). Among the 12 selected studies, 8 studies reported an association between the ERCC1 C8092A polymorphism and glioma risk, including 3008 glioma cases and 4319 controls (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk

Zhou

Zhao

2015

Genet. Mol. Res.

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ABSTRACT. Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive. We conducted a meta-analysis of 12 studies to determine the association between ERCC1 rs3212986 and ERCC2 rs13181 genes and glioma susceptibility. We searched for relevant studies in both Chinese and English in PubMed, Web of Science, Cochrane Library, and EMBASE through January 1, 2014, and identified 3939 cases and 5407 controls. The results showed that individuals carrying the ERCC1 rs3212986 AA genotype had higher risk of glioma compared with the CC genotype, with a pooled odds ratio = 1.29, 95% confidence interval = 1.07-1.55. Subgroup analysis showed that the ERCC1 rs3212986 AA genotype was significantly associated with an increased risk of glioma in the Chinese population (odds ratio = 1.37, 95% confidence interval = 1.07-1.55), but no association in Caucasian Chinese. No significant association was observed between ERCC2 rs13181 polymorphisms and glioma risk. The results of our metaanalysis strongly suggested that the ERCC1 rs3212986 polymorphism 2869 ERCC1 and ERCC2 and glioma risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (1): 2868-2875(2015 was associated with a higher susceptibility to glioma, particularly in the Chinese population. Studies including a larger sample size and more specified information regarding pathological types of glioma are needed to confirm our results.

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Section: Resultsmentioning

confidence: 99%

Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk

Zhou

Zhao

2015

Genet. Mol. Res.

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“…ERCC1 is a protein that functions in nucleotide excision repair of damaged DNA. It has been reported that overexpreesion of ERCC1 are associated with tumor resistance to chemotherapies or radiotherapies (Kim et DOI:http://dx.doi.org/10.7314/APJCP.2012.13.11.5619 Role of Integrin-Linked Kinase in Multi-drug Resistance of SGC7901/DDP Human Gastric Carcinoma Cells al., 2008Vilmar et al, 2009;Chen et al, 2012), since DNA damage is the major mechanism of anti-tumor activity of these treatments. GST-π belongs to a family of glutathione S-transferases enzymes that play a role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds like cisplatin with reduced glutathione (Karen-Ng et al, 2011;Maeda et al, 2012).…”

Section: Ilk Silencing Downregulated the Expression Of Ercc1 Gst-π Amentioning

confidence: 99%

Role of Integrin-Linked Kinase in Multi-drug Resistance of Human Gastric Carcinoma SGC7901/DDP Cells

Song

Jiang²,

Zhao³

2012

Asian Pacific Journal of Cancer Prevention

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Gastric carcinoma is a leading cause of cancer death in the world and multi-drug resistance (MDR) is an essential aspect of gastric carcinoma chemotherapy failure. Recent studies have shown that integrin-linked kinase (ILK) is involved in metastasis of human tumors, expression silencing of ILK inhibiting the metastasis of several types of cultured human cancer cells. However, the role and potential mechanism of ILK to reverse the multidrug resistance in human gastric carcinoma is not fully clear. In this report, we focused on roles of expression silencing of ILK in multi-drug resistance reversal of human gastric carcinoma SGC7901/DDP cells, including increased drug sensitivity to cisplatin, cell apoptosis rates, and intracellular accumulation of Rhodamine-123, and decreased mRNA and protein expression of multi-drug resistance gene (MDR1), multi-drug resistanceassociated protein (MRP1), excision repair cross-complementing gene 1 (ERCC1), glutathione S-transferase -π (GST-π) and RhoE, and transcriptional activation of AP-1 and NF-κB in ILK silenced SGC7901/DDP cells. We also found that there was a decreased level of p-Akt and p-ERK. The results indicated that ILK might be used as a potential therapeutic strategy to combat multi-drug resistance through blocking PI3K-Akt and MAPK-ERK pathways in human gastric carcinoma.

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“…Another study in the United States showed that no significant association existed between the ERCC2 rs13181 polymorphism and the risk of adult glioma (Liu et al, 2009). However, several recent studies reported that the ERCC2 rs13181 polymorphism was associated with glioma risk (Chen et al, 2012;Zhang, 2013;Rodriguez-Hernandez, 2014). The inconsistency of these studies might be explained by differences in population background, sample size, and also by chance.…”

Section: Discussionmentioning

confidence: 86%

“…The initial search identified 46 studies for ERCC2 rs13181, of which 11 met the selection criteria (Caggana et al, 2001;Wrensch et al, 2005;Yang et al, 2005;Liu et al, 2009;McKean-Cowdin et al, 2009;Rajaraman et al, 2010;Chen et al, 2012;Luo et al, 2013;Salnikova et al, 2013;Zhang, 2013;Rodriguez-Hernandez et al, 2014). Among the excluded studies, four were dissertations, three were reviews, 21 did not investigate the ERCC2 rs13181 polymorphism, eight did not report the association between the ERCC2 rs13181 polymorphism and risk of glioma, and two were replication studies.…”

Section: Resultsmentioning

confidence: 99%

Association between the ERCC2 rs13181 polymorphism and the risk of glioma: a meta-analysis

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Several studies have focused on the association between the ERCC2 rs13181 polymorphism and glioma risk, but the results were inconclusive. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma. We searched and collated the relevant studies in both Chinese and English through the PubMed, Web of Science, Cochrane Library, and EMBASE databases published through June 1, 2014. A total of 11 studies for ERCC2 rs13181 were selected; these included 3456 glioma cases and 4957 controls. Using fixed-effects model analysis, we found that no significant difference could be identified between the ERCC2 rs13181 polymorphism and the risk of glioma. Subgroup analysis showed that the ERCC2 rs13181 GT and TT genotypes were significantly associated with an increased risk of glioma in the Chinese population [odds ratio (OR) = 1.47, 95% confidence interval (CI) = 1.17-1.85; and OR = 1.50, 95%CI = 1.02-2.22, respectively], but no significant increased risk of glioma was detected with these genotypes in the Caucasian populations. No T.L. Jia et al. 12578©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 12577-12584 (2015) publication bias was identified in this meta-analysis. Our meta-analysis strongly suggested that ERCC2 rs13181 was associated with a higher susceptibility to glioma in the Chinese population.

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DNA Repair Gene ERCC1 and XPD Polymorphisms Predict Glioma Susceptibility and Prognosis

Cited by 31 publications

References 29 publications

Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk

Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk

Role of Integrin-Linked Kinase in Multi-drug Resistance of Human Gastric Carcinoma SGC7901/DDP Cells

Association between the ERCC2 rs13181 polymorphism and the risk of glioma: a meta-analysis

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