DNA sequencing reveals AMELX, ODAM and MMP20 variations in dental fluorosis

Tremillo-Maldonado, Omar; Molina-Frechero, Nelly; González-González, Rogelio; Damián-Matsumura, Pablo; Sánchez-Pérez, Leonor; Sicco, Estefanía; Suárez, Mariana; Bologna‐Molina, Ronell

doi:10.1016/j.archoralbio.2019.104626

Cited by 9 publications

(11 citation statements)

References 21 publications

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“…The potential role of single nucleotide variants of ODAM, MMP20, and AMELX in the development of dental fluorosis was recently investigated using DNA sequencing. Results from this study indicated rs1514392 of ODAM, did not have a significant effect on the severity of dental fluorosis between populations, whilst rs1784418 of MMP20 was significantly associated with susceptibility to dental fluorosis (Tremillo-Maldonado et al, 2020). Given the apparent functional correlation of ODAM and MMP20 (Lee et al, 2010;Lee, et al, 2012b), future research from a larger and broader population sample could provide additional findings of genetic susceptibility to dental fluorosis which might explain the observed phenotypic variation.…”

Section: The Role Of Odontogenic Ameloblastassociated Protein In Odon...mentioning

confidence: 68%

The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease

et al. 2022

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Junctional epithelium (JE) is a vital epithelial component which forms an attachment to the tooth surface at the gingival sulcus by the adhesion of protein complexes from its basal layer. Disruption of the JE is associated with the development of gingivitis, periodontal disease, and alveolar bone loss. Odontogenic ameloblast-associated (ODAM) is comprised of a signal peptide and an ODAM protein with 12 putative glycosylation sites. It is expressed during odontogenesis by maturation stage ameloblasts and is incorporated into the enamel matrix during the formation of outer and surface layer enamel. ODAM, as a secreted protein which is accumulated at the interface between basal lamina and enamel, mediates the adhesion of the JE to the tooth surface; and is involved with extracellular signalling of WNT and ARHGEF5-RhoA, as well as intracellular signalling of BMP-2-BMPR-IB-ODAM. ODAM is also found to be highly expressed in salivary glands and appears to have implications for the regulation of formation, repair, and regeneration of the JE. Bioinformatics and research data have identified the anti-cancer properties of ODAM, indicating its potential both as a prognostic biomarker and therapeutic target. Understanding the biology of ODAM will help to design therapeutic strategies for periodontal and dental disorders.

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Section: The Role Of Odontogenic Ameloblastassociated Protein In Odon...mentioning

confidence: 68%

The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease

et al. 2022

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“…A cross-sectional study [14] in Mexican children revealed an association of rs 412777 polymorphism in the COL1A2 gene with dental fluorosis. MMP20 was supposed to be related to the various phenotypes of dental fluorosis and may serve as a protective marker [15]. These would provide some evidence for identifying those people who are at risk of developing dental fluorosis in their later lives.…”

Section: Dental Cariesmentioning

confidence: 99%

The Application of Fluoride in Dental Caries

Sun¹,

Luo²,

Wan³

2021

Dental Caries

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The most efficient way to prevent caries is by using fluoridated dental products. Fluoride can reduce enamel demineralization and promote enamel remineralization. In terms of prevention, the topical application of fluoride is accessible, which includes fluoride toothpaste, fluoride varnish, fluoride gel, and mouth rinse. Besides, the application of fluoride is systematical. In some countries, fluoride is added into water, salt, or milk. Fluoride is also used for the medical treatment of early dental caries. However, fluoride is a double-edged sword. Excessive fluoride intake will cause toxic reactions, and dental fluorosis is caused by a high intake of fluorides during tooth development.

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“…There is evidence to suggest that also in humans, polymorphism in genes involved in the formation of dental enamel is related to variation in dental fluorosis susceptibility (Küchler et al, 2017;Tremillo-Maldonado et al, 2020).…”

Section: Effects Of Fluoride On Animals and Humansmentioning

confidence: 99%

“…Studies on inbred mouse ( Mus musculus ) strains have also demonstrated genetic variability in susceptibility to F‐toxicity during amelogenesis (enamel formation) and osteogenesis (Everett, 2010; Kobayashi et al, 2014). There is evidence to suggest that also in humans, polymorphism in genes involved in the formation of dental enamel is related to variation in dental fluorosis susceptibility (Küchler et al, 2017; Tremillo‐Maldonado et al, 2020).…”

Section: Effects Of Fluoride On Animals and Humansmentioning

confidence: 99%

The eruption of the Laacher See volcano (~13,000 years BP) and possible fluoride poisoning amongst contemporaneous wildlife and human foragers—Outline of a hypothesis and the way to test it

Riede

Kierdorf

2020

Intl J of Osteoarchaeology

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At about 13,000 calendar years before present (BP) the Laacher See volcano, located in present-day western Germany, erupted catastrophically. It has been argued that this eruption and its attendant ash fallout played a causal role in the demographic and cultural change documented archaeologically amongst contemporaneous human hunter-gatherer populations in northern Europe. The population displacement and subsequent changes in material culture are clearly visible in the archaeological record, especially in southern Scandinavia. A particular challenge to this scenario is the apparently paradoxical proposition that the effects of the Laacher See volcanic eruption became more pronounced with distance from the volcano itself. There are, however, several documented detrimental health effects of volcanic eruptions that, owing to the physical properties of the ash fallout, actually do become more severe with distance from the eruptive centre. Volcanic eruptions introduce large amounts of chemicals into the atmosphere and deposit these, via ash fallout, in the environment. Here, we explore the hypothesis that the deposition of tephra with a high fluoride content contributed to making the landscapes affected by Laacher See ash fallout unsuitable for wildlife and humans. We briefly describe the possible fate of the fluoride released by the Laacher See volcanic eruption and its potential effects on northern European ecosystems with particular attention to impact pathways from wildlife to humans and to humans directly. Finally, we outline possible avenues of empirically investigating fluoride toxicosis in wildlife, especially large mammalian herbivores, following this volcanic event.

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DNA sequencing reveals AMELX, ODAM and MMP20 variations in dental fluorosis

Cited by 9 publications

References 21 publications

The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease

The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease

The Application of Fluoride in Dental Caries

The eruption of the Laacher See volcano (~13,000 years BP) and possible fluoride poisoning amongst contemporaneous wildlife and human foragers—Outline of a hypothesis and the way to test it

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