DNA sequencing through graphene nanogap: a model of sequential electron transport

Isaeva, O. G.; Katkov, V. L.; Osipov, V. A.

doi:10.1140/epjb/e2014-50400-2

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…In the context of nanogap electrode device performance, the orientation of the bases with respect to the electrodes can be of importance and requires further attention. ,, In the work of Prasongkit et al, they have considered the effect of rotation and lateral translation of the bases on the transmission functions . In a similar spirit, we have also taken into consideration the effect of rotation and translation of the bases, and these results are presented in the SI.…”

Section: Resultsmentioning

confidence: 99%

Prospects of Graphene–hBN Heterostructure Nanogap for DNA Sequencing

Shukla

Jena

Grigoriev

et al. 2017

ACS Appl. Mater. Interfaces

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Recent advances in solid-state nano-device-based DNA sequencing are at the helm of the development of a new paradigm, commonly referred to as personalized medicines. Paying heed to a timely need for standardizing robust nanodevices for cheap, fast, and scalable DNA detection, in this article, the nanogap formed by the lateral heterostructure of graphene and hexagonal boron nitride (hBN) is explored as a potential architecture. These heterostructures have been realized experimentally, and our study boasts the idea that the passivation of the edge of the graphene electrode with hBN will solve many of practical problems, such as high reactivity of the graphene edge and difficulty in controlled engineering of the graphene edge structure, while retaining the nanogap setup as a useful nanodevice for sensing applications. Employing first-principle density-functional-theory-based nonequilibrium Green's function methods, we identify that the DNA building blocks, nucleobases, uniquely couple with the states of the nanogap, and the resulting induced states can be attributed as leaving a fingerprint of the DNA sequence in the computed current-voltage (I-V) characteristic. Two bias windows are put forward: lower (1-1.2 V) and higher (2.7-3 V), where unique identification of all four bases is possible from the current traces, although higher sensitivity is obtained at the higher voltage window. Our study can be a practical guide for experimentalists toward development of a nanodevice DNA sensor based on graphene-hBN heterostructures.

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Section: Resultsmentioning

confidence: 99%

Prospects of Graphene–hBN Heterostructure Nanogap for DNA Sequencing

Shukla

Jena

Grigoriev

et al. 2017

ACS Appl. Mater. Interfaces

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“…However, nanopores are usually made in insulating membranes with the thickness up to 15 bases, which makes it difficult to sequence individual bases by such devices. At the same time, graphene has a thickness of only 0.335 nm (equivalent to the distance between two bases in the DNA chain) that provides a suitable membrane for sequencing [ 45 , 46 , 47 , 48 , 49 ].…”

Section: Gnrs In Biomedicinementioning

confidence: 99%

Graphene Nanoribbons: Prospects of Application in Biomedicine and Toxicity

et al. 2021

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Graphene nanoribbons are a type of graphene characterized by remarkable electrical and mechanical properties. This review considers the prospects for the application of graphene ribbons in biomedicine, taking into account safety aspects. According to the analysis of the recent studies, the topical areas of using graphene nanoribbons include mechanical, chemical, photo- and acoustic sensors, devices for the direct sequencing of biological macromolecules, including DNA, gene and drug delivery vehicles, and tissue engineering. There is evidence of good biocompatibility of graphene nanoribbons with human cell lines, but a number of researchers have revealed toxic effects, including cytotoxicity and genotoxicity. Moreover, the damaging effects of nanoribbons are often higher than those of chemical analogs, for instance, graphene oxide nanoplates. The possible mechanism of toxicity is the ability of graphene nanoribbons to damage the cell membrane mechanically, stimulate reactive oxidative stress (ROS) production, autophagy, and inhibition of proliferation, as well as apoptosis induction, DNA fragmentation, and the formation of chromosomal aberrations. At the same time, the biodegradability of graphene nanoribbons under the environmental factors has been proven. In general, this review allows us to conclude that graphene nanoribbons, as components of high-precision nanodevices and therapeutic agents, have significant potential for biomedical applications; however, additional studies of their safety are needed. Particular emphasis should be placed on the lack of information about the effect of graphene nanoribbons on the organism as a whole obtained from in vivo experiments, as well as about their ecological toxicity, accumulation, migration, and destruction within ecosystems.

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“…There are a lot of reports demonstrating the adaptation of graphene and graphene based nanomaterials for the applications of DNA detection. For example, as a label-free and amplification-free single-molecule approach, the GNP structure is outstanding in the application of DNA sequencing [ 29 , 30 , 31 , 32 ], similar as the graphene nanogaps [ 33 ]. Meanwhile, pristine graphene and functionalized graphene (GO, rGO) present strong capability in the synthesis of electrochemical, electronic and optical biosensors for DNA detection [ 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Graphene and Graphene-Based Nanomaterials for DNA Detection: A Review

Wang

et al. 2018

Molecules

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DNA detection with high sensitivity and specificity has tremendous potential as molecular diagnostic agents. Graphene and graphene-based nanomaterials, such as graphene nanopore, graphene nanoribbon, graphene oxide, and reduced graphene oxide, graphene-nanoparticle composites, were demonstrated to have unique properties, which have attracted increasing interest towards the application of DNA detection with improved performance. This article comprehensively reviews the most recent trends in DNA detection based on graphene and graphene-related nanomaterials. Based on the current understanding, this review attempts to identify the future directions in which the field is likely to thrive, and stimulate more significant research in this subject.

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DNA sequencing through graphene nanogap: a model of sequential electron transport

Cited by 9 publications

References 25 publications

Prospects of Graphene–hBN Heterostructure Nanogap for DNA Sequencing

Prospects of Graphene–hBN Heterostructure Nanogap for DNA Sequencing

Graphene Nanoribbons: Prospects of Application in Biomedicine and Toxicity

Graphene and Graphene-Based Nanomaterials for DNA Detection: A Review

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