DNA Strand Breaks Induced by 0–4 eV Electrons: The Role of Shape Resonances

Martin, F. W.; Burrow, Paul; Cai, Zhongli; Cloutier, Pierre; Hunting, Darel J.; Sanche, Léon

doi:10.1103/physrevlett.93.068101

Cited by 474 publications

(500 citation statements)

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“…The lowest peak in the modeled capture cross-section, which occurs at 0.39 eV in the gas phase, was shifted by 0.41 eV to match that in the SSB yield. The necessity of introducing this positive shift could be explained by the phosphate charge which in DNA is relatively close to the bases, thus producing a net destabilization which slightly exceeds that of the polarization induced by the transient anion [18]. The good agreement between the experimental and simulated SSBs yield functions in the 0-4 eV range may be considered as a strong argument confirming the involvement of shape resonances localized on nucleobases in the formation of LEE-induced strand breaks in DNA.…”

Section: Dna Damage Induced By Low Energy Electronsmentioning

confidence: 53%

“…On the other hand, at lower energies the cleavage process is due to the formation of transient resonance anions [1,2,[15][16][17][18]. Thus, the SSB and DSB maxima on the yield function observed around 8 and 10 eV (Figure 21-3), [12].…”

Section: Dna Damage Induced By Low Energy Electronsmentioning

confidence: 99%

“…below 5 eV), shape resonances localized at nucleobases are suspected to be responsible for the observed strand damage [18,22]. Due to the development of more sensitive techniques to assay SSB and DSB in DNA, the 0-4 eV range of incident electrons energies were studied by Martin and coworkers [18,22] (Figure 21-4). This experimental picture could be reproduced by a model that simulates the electron capture cross-section as it might appear in DNA owing to the * anion states of the bases.…”

Section: Dna Damage Induced By Low Energy Electronsmentioning

confidence: 99%

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Stable Valence Anions of Nucleic Acid Bases and DNA Strand Breaks Induced by Low Energy Electrons

Rak

Mazurkiewicz

Kobyłecka

et al. 2008

Challenges and Advances in Computational Chemistry and Physics

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Abstract:The last decade has witnessed immense advances in our understanding of the effects of ionizing radiation on biological systems. As the genetic information carrier in biological systems, DNA is the most important species which is prone to damage by high energy photons. Ionizing radiations destroy DNA indirectly by forming low energy electrons (LEEs) as secondary products of the interaction between ionizing radiation and water. An understanding of the mechanism that leads to the formation of single and double strand breaks may be important in guiding the further development of anticancer radiation therapy. In this article we demonstrate the likely involvement of stable nucleobases anions in the formation of DNA strand breaks -a concept which the radiation research community has not focused on so far. In Section 21.1 we discuss the current status of studies related to the interaction between DNA and LEEs. The next section is devoted to the description of proton transfer induced by electron attachment to the complexes between nucleobases and various proton donorsa process leading to the strong stabilization of nucleobases anions. Then, we review our results concerning the anionic binary complexes of nucleobases with particular emphasize on the GC and AT systems. Next, the possible consequences of interactions between DNA and proteins in the context of electron attachment are briefly discussed. Further, we focus on existing proposal of single strand break formation in DNA. Ultimately, open questions as well perspectives of studies on electron induced DNA damage are discussed

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Section: Dna Damage Induced By Low Energy Electronsmentioning

confidence: 53%

Section: Dna Damage Induced By Low Energy Electronsmentioning

confidence: 99%

Section: Dna Damage Induced By Low Energy Electronsmentioning

confidence: 99%

See 1 more Smart Citation

Stable Valence Anions of Nucleic Acid Bases and DNA Strand Breaks Induced by Low Energy Electrons

Rak

Mazurkiewicz

Kobyłecka

et al. 2008

Challenges and Advances in Computational Chemistry and Physics

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“…The Feshbach resonance with a hole in the n O oxygen lone pair orbital appears as a weaker peak at 7.85 eV in the D À /EtOD spectrum and as an indistinct shoulder at the same energy in the (M À 1) À /EtOH spectrum. 3 Comparison of selected DEA spectra with vibrational excitation cross-sections (measured at 1351) and photoelectron spectra for ethanol (2). The PE spectrum is shown shifted by À4.65 eV; a weak sharp peak due to a N 2 impurity is marked.…”

Section: Methanol (1)mentioning

confidence: 99%

Electron-induced chemistry of alcohols

Ibănescu

May

Monney

et al. 2007

Phys. Chem. Chem. Phys.

104

127

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We studied dissociative electron attachment to a series of compounds with one or two hydroxyl groups. For the monoalcohols we found, apart from the known fragmentations in the 6-12 eV range proceeding via Feshbach resonances, also new weaker processes at lower energies, around 3 eV. They have a steep onset at the dissociation threshold and show a dramatic D/H isotope effect. We assigned them as proceeding via shape resonances with temporary occupation of s * O-H orbitals. These low energy fragmentations become much stronger in the larger molecules and the strongest DEA process in the compounds with two hydroxyl groups, which thus represent an intermediate case between the behavior of small alcohols and the sugar ribose which was discovered to have strong DEA fragmentations near zero electron energy [S. Ptasin´ska, S. Denifl, P. Scheier and T. D. Ma¨rk, J. Chem. Phys., 2004, 120, 8505]. Above 6 eV, in the Feshbach resonance regime, the dominant process is a fast loss of a hydrogen atom from the hydroxyl group. In some cases the resulting (M À 1) À anion (loss of hydrogen atom) is sufficiently energyrich to further dissociate by loss of stable, closed shell molecules like H 2 or ethene. The fast primary process is state-and site selective in several cases, the negative ion states with a hole in the n O orbital losing the OH hydrogen, those with a hole in the s C-H orbitals the alkyl hydrogen.

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“…9,10 In order to estimate the effect of electrons (and other negative species) on plasmid DNA, a high transmission metallic mesh was placed in front of the sample. A negative potential up to À30 V with respect to ground was applied to the mesh to suppress the electron flux reaching the sample from plasma jet.…”

mentioning

confidence: 99%