1999
DOI: 10.1016/s0959-440x(99)80040-2
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DNA structure: cations in charge?

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Cited by 201 publications
(195 citation statements)
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“…This partial stabilization from three-centered H-bonds is supported by a recent molecular dynamics simulation of three dodecamer A tract sequences, which indicated that the three-centered H-bonds are a consequence of rather than a driving force for forming the highly propeller-twisted conformation (45). Other sources of stabilization potentially arise from improved base stacking interactions (4,45) and ion binding in the minor groove (31,33,46).…”
Section: Discussionmentioning
confidence: 84%
“…This partial stabilization from three-centered H-bonds is supported by a recent molecular dynamics simulation of three dodecamer A tract sequences, which indicated that the three-centered H-bonds are a consequence of rather than a driving force for forming the highly propeller-twisted conformation (45). Other sources of stabilization potentially arise from improved base stacking interactions (4,45) and ion binding in the minor groove (31,33,46).…”
Section: Discussionmentioning
confidence: 84%
“…The possibility that monovalent cations can replace ordered water molecules at the floor of the narrowed minor groove in AT tracts of B form duplex DNA has generated considerable interest and controversy (34,35). The crystallographic evidence in favor of this proposition is based entirely on cryogenic diffraction data (36)(37)(38).…”
Section: Discussionmentioning
confidence: 99%
“…and function of DNA and RNA. Mono-and divalent cations are thought to induce bending in DNA duplexes [1,2], and are also known to stabilize triplex [3,4], and quadruplex [5,6] structures. Metal cations are also required for the proper folding and function of many forms of RNA, including most ribozymes [7,8].…”
mentioning
confidence: 99%