2005
DOI: 10.1201/9781420036992.ch7
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DNA-Templated Assembly of Helical Multichromophore Aggregates

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Cited by 3 publications
(4 citation statements)
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“…One is intercalation, first reported by Fiel and co-workers . The others are external (or groove) binding and, under some conditions, outside stacking (or aggregation) along the surface of the DNA host. ,, Because the shape of a porphyrin is not complementary to that of B-form DNA, high-affinity binding always involves a structural reorganization of the host, i.e., an induced fit . External binding, the norm for metalloporphyrins bearing axial ligands, , involves local melting of the DNA structure and formation of a binding pocket to optimize a mix of hydrophobic and electrostatic interactions.…”
Section: Discussionmentioning
confidence: 99%
“…One is intercalation, first reported by Fiel and co-workers . The others are external (or groove) binding and, under some conditions, outside stacking (or aggregation) along the surface of the DNA host. ,, Because the shape of a porphyrin is not complementary to that of B-form DNA, high-affinity binding always involves a structural reorganization of the host, i.e., an induced fit . External binding, the norm for metalloporphyrins bearing axial ligands, , involves local melting of the DNA structure and formation of a binding pocket to optimize a mix of hydrophobic and electrostatic interactions.…”
Section: Discussionmentioning
confidence: 99%
“…Evidence that points to cooperative binding of Zn(tMe 2 D4) includes the difference spectrum in Figure 8 as well as with the bisignate CD spectra exhibited by the adducts formed with [poly(dG-dC)] 2 and [poly(dA-dT)] 2 . In the context of cationic porphyrins, the most commonly recognized form of cooperative binding to DNA is self-stacking on the surface of the host (25,29,79). However, more traditional modes of ligand binding can also exhibit cooperativity when binding involves reorganization of the DNA structure (80).…”
Section: Interactions Of Dna With Zn(tme 2 D4)mentioning
confidence: 99%
“…Uptake of Zn(tMe 2 D4) is very different because binding is a strictly cooperative process and the motif depends on the base content of the DNA host. Heretofore, external stacking has been widely recognized as a binding motif compatible with cooperative uptake of a cationic porphyrin (22,56,79), but cooperative binding may occur whenever substantial structural reorganization is necessary. Recognizing when cooperative binding occurs is important because it impacts everything from competitive binding assays (84) to comparative kinetics studies (85,86).…”
Section: Conclusion and Perspectivementioning
confidence: 99%
“…It is known that the molecules of DNA, RNA and polynucleotides also represent linear polyanions with intercharge distances corresponding to the thickness of the π-electronic system. They are known as a good scaffold for the self-assembly of cationic porphyrins occurring at low P/D ratios that results in the formation of extended porphyrin aggregates on the polymer exterior [41,42,61,62]. This process induces multiple transformations in porphyrin spectra, such as hypochromism and shift of the Soret absorption band (a blue shift in the case of H-aggregates, and a red shift for J-aggregates); a substantial change in the shape, position and intensity of the dye emission band; and a rise in the fluorescence polarization degree.…”
Section: Discussionmentioning
confidence: 99%