DNA typing for HLA class I: Subsets of HLA-A2 and of A28

Fernandez-Viña, M.A.; Falco, Michela; Sun, Yiping; Šťastný, Peter

doi:10.1016/0198-8859(91)90234-z

Cited by 2 publications

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“…The practical significance of the tyrosinase polymorphism appears to be limited, though, as when we tested eight HLA-A2 melanomas that expressed tyrosinase, all were recognized by CTL 210/9 and IVSB. This is probably also due to the fact that the HLA-A2 subtype of patient SK29(AV) is A2.1, which is by far the most frequent HLA-A2 subtype, being found in 96 % of HLA-A2 Caucasians [44].…”

Section: Discussionmentioning

confidence: 99%

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

et al. 1994

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A number of cytolytic T lymphocyte (CTL) clones derived from several melanoma patients have been found to recognize a majority of melanomas from HLA-A2 patients. We have reported previously that two such CTL clones recognize a product of the tyrosinase gene that is presented by HLA-A2. Here we show that one of these CTL clones recognizes a peptide encoded by the first nine amino acids of the putative signal sequence of tyrosinase. The other CTL clone recognizes a different tyrosinase peptide corresponding to amino acids 368-376. Both peptides contain consensus motifs of HLA-A2 binding peptides.

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Section: Discussionmentioning

confidence: 99%

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

et al. 1994

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“…The most relevant epitope in this subdomain comprises residues 309-317 (ILKEPVHGV). CTL responses to this epitope have been widely detected, since HLA-A2 is the most frequent alíele in the world's population (13). Anchor residues in this epitope are Leu-310 and Val-317.…”

Section: Hiv Proteins As Targets Of the Ctl Responsementioning

confidence: 99%

Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase (Review)

Menéndez‐Arias¹,

Más²,

Domingo³

1998

Viral Immunology

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Cytotoxic T lymphocytes (CTL) play an important role in the control of human immunodeficiency virus (HIV) infection. CTL responses have been demonstrated for most of the HIV gene products, predominantly gag, pol, and env-encoded proteins, and also for the regulatory proteins Nef, Tat, Vif, or Rev. The HIV-1 reverse transcriptase (RT), which derives from expression of the pol gene, is an important target of cellular immune responses in infected individuals. More than 40 different peptides containing RT-specific CTL epitopes have been identified. The most conserved and frequently detected are located in the 'fingers' and 'palm' subdomains of the enzyme, but other epitopes have been found in the 'thumb' and 'connection' subdomains as well as in the RNase H domain. Studies on the sequence variability and functional role of amino acids forming CTL epitopes are relevant for addressing important questions relative to viral escape from immmune control and the future design of anti-AIDS vaccines.

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DNA typing for HLA class I: Subsets of HLA-A2 and of A28

Cited by 2 publications

References 0 publications

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase (Review)

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