DNA vaccines in veterinary use

Redding, Laurel E.; Weiner, David B.

doi:10.1586/erv.09.77

Cited by 101 publications

(64 citation statements)

References 108 publications

(66 reference statements)

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“…The vaccines have been advanced to be applied in the management of other complicated medical conditions in genetics such as neurological disorders and cancer (Shimamura et al, 2011;Alam and McNeel, 2010). The technology of gene modification has also been employed in the veterinary field to help the control of the West Nile virus, hematopoietic necrosis virus and melanoma in horses, salmon and dogs, respectively (Redding and Weiner, 2009). Among the applications in humans, the licensing of DNA vaccines is limited because of the possible implications that have not been thoroughly investigated and approved.…”

Section: Overview Of Gene Vaccinationmentioning

confidence: 99%

DNA Vaccination Associated with Eliminating Inheritance Risks during Embryo Development: A Review

Margiana¹

2016

OnLine Journal of Biological Sciences

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Abstract:The process of immunization using modified DNA is essential whenever scientists desire to trigger an artificial response in the host's body to improve immunity. The use of DNA vaccines awakens the somatic cells of the host to produce antigens that will assist the body to prepare to fight infections through preventive measures triggered by the vaccines. These biological inventions have assisted in controlling diseases as well as eliminating some health conditions. Scientific analyses have shown how the plasmid DNA could trigger an artificial immune response in living organisms when associated with the antigens that are plasmidencoded. Such revelations have demonstrated that this invention has a possible therapeutic application as vaccination to prevent numerous pathogens and their related infections. This paper reviews the concept of DNA vaccination and its effects on embryogenesis. The paper first discusses an overview of DNA vaccines and relates it to the production and expression processes. The effects on embryo development have also been described. This review also explains the advantages and disadvantages related to DNA vaccines' administration and the mechanisms employed to enhance plasmid effectiveness.

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Section: Overview Of Gene Vaccinationmentioning

confidence: 99%

DNA Vaccination Associated with Eliminating Inheritance Risks during Embryo Development: A Review

Margiana¹

2016

OnLine Journal of Biological Sciences

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“…It is the first marketable DNA vaccine and its prices are comparable to other existing vaccines against WNV. 31 The DNA vaccines available in the market today are summarized in Table II. It can be taken as a first step towards DNA vaccination in human beings just like first vaccine against smallpox was started by taking antigen samples from the cow.…”

Section: In the Marketmentioning

confidence: 99%

DNA Mediated Vaccines Delivery Through Nanoparticles

Shah¹,

Ali²,

Rostami³

et al. 2015

j nanosci nanotechnol

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Vaccination has led to the eradication of those diseases which had once claimed millions of lives worldwide; however, it is accompanied with a number of dis-advantages especially safety issues until the entry of DNA vaccines. The DNA vaccines have been emerged as the best remedy for problematic diseases being capable of producing humoral and cellular immune responses as well as the safest vaccines so far. However, the magnitude of immune responses produced in primates is lower than that in experimental animals. There are several reasons described theoretically for this limited efficacy and a number of novel approaches have been applied to boost their immune responses, e.g., use of more efficient promoters and coding optimization, addition of traditional or genetic adjuvants, electroporation, intradermal delivery and various prime-boost strategies. One of these strategies is controlled antigen administration of plasmid DNA through microspheres and nanoparticles. This approach is accompanied with a number of advantages to overcome the limitations of traditional delivery systems in terms of stability, solubility and pharmacology. Furthermore, the surface structure of a virus highly resembles with a nanoparticle because of their geometrical regularities and nanoscale dimensions; therefore, the engineering of nanoparticles is based upon principles of natural virus attack which will be the best tool for vaccination. There is evidence that these immune responses can be augmented by properly structured nanosized particles (nanoparticles) that may avoid DNA degradation and facilitate targeted delivery to antigen presenting cells. Adsorption, formulation or encapsulation with particles has been found to stabilize DNA formulations. The use of nanoparticles for DNA vaccine delivery is a platform technology and has been applied for delivery of a variety of existing and potential vaccines successfully.

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“…The demand for plasmid DNA (pDNA) for vaccine and gene therapy applications has increased during the past few years in response to several technical improvements and the recent licensing of four DNA products for veterinary applications (Redding and Weiner, 2009). A detailed review on the current progress in this field can be found elsewhere (Kutzler and Weiner, 2008;Redding and Weiner, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…A detailed review on the current progress in this field can be found elsewhere (Kutzler and Weiner, 2008;Redding and Weiner, 2009). pDNA, used for gene delivery, has attracted a lot of interest since it offers several advantages over viral gene delivery, e.g.…”

Section: Introductionmentioning

confidence: 99%