DNA walker induced “signal on” fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer

Yang, Gaojian; Li, Zhiyang; Usman, Rabia; Chen, Zhu; Liu, Yuan; Li, Song; Chen, Hui; Deng, Yan; Fang, Yile; He, Nongyue

doi:10.1016/j.cclet.2024.109930

Chinese Chemical Letters

2025

DOI: 10.1016/j.cclet.2024.109930

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DNA walker induced “signal on” fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer

Gaojian Yang,

Zhiyang Li,

Rabia Usman

et al.

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2025

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Cited by 3 publications

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Aptasensors and Advancement in Molecular Recognition Technology

Napit,

Jaysawal,

Chowdhury

et al. 2024

Adv Materials Technologies

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Synthetic oligonucleic acids known as aptamers exhibit remarkable selectivity and affinity for target recognition and binding. Selected via an iterative process known as “selective evolution of ligands by exponential enrichment” (SELEX), aptamers fold into defined 3D conformations to interact with their targets. The incorporation of aptamers as recognition elements has driven notable progress in biosensors, giving rise to the development of aptasensors. Here, the process of aptamer discovery and the development of various types of aptasensors are summarized. The fundamental design principles of aptasensors are elaborated along with the superiority of aptamers compared to antibodies. The various modes employed by aptasensors, such as structure‐switching design, hybridization chain reaction amplification, enzyme‐assisted recycling, and split aptamer design are examined. Further light is shed on the diverse landscape of aptasensors, their adaptability to different analytes aptasensors as well as their potential to propel advancements in modern biosensor technology. As a nucleic acids‐based biosensor platform, aptasensors poise to become a next generation of sensitive and cost‐effective technology to shape the future of molecular recognition in biosensing.

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Aptasensors and Advancement in Molecular Recognition Technology

Napit,

Jaysawal,

Chowdhury

et al. 2024

Adv Materials Technologies

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Dual-mode ultrasensitive detection of acute leukemia gene Pax-5a based on smart DNA programmed dendrimer

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Zhao,

Lai

et al. 2025

Biosensors and Bioelectronics

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On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection

Xu,

Li,

Wang

et al. 2024

Chem. Sci.

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scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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DNA walker induced “signal on” fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer

Cited by 3 publications

References 45 publications

Aptasensors and Advancement in Molecular Recognition Technology

Aptasensors and Advancement in Molecular Recognition Technology

Dual-mode ultrasensitive detection of acute leukemia gene Pax-5a based on smart DNA programmed dendrimer

On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection

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