DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes

Abstract

Background: RAGE receptor plays a critical role in many inflammatory disorders. Results: Functional interaction between RAGE and DAP10 coordinately regulates S100A8/A9-mediated cell survival. Conclusion: DAP10 membrane adaptor is critically involved in RAGE-mediated survival signaling upon S100A8/A9 binding. Significance: This is the first report demonstrating that RAGE-mediated survival signaling is critically regulated by DAP10 interaction.

SARS-CoV-2-mediated inflammatory response in lungs: should we look at RAGE?

“…The signaling cascades triggered by RAGE engagement are much more complex and diverse than initially thought, considering that RAGE-binding proteins located in either the cytoplasm and or on the plasma membrane can modulate RAGE-mediated signaling diversity, in addition to the conformational flexibility acquired after the engagement, ranging from homo-dimerization, homo-multimerization and even to hetero-dimerization [19,20].…”

exSSSRs (extracellular S100 soil sensor receptors)‐Fc fusion proteins work as prominent decoys to S100A8/A9‐induced lung tropic cancer metastasis

“…The TLR is itself a “soil sensor” located in cancer cells, enabling the cells to approach distant soil signal‐emitting organs such as the lungs, a well‐known location of melanoma metastasis . After publication of the report by Hiratsuka et al ., the RAGE was also included as a soil sensor for S100A8/A9 . We then found further evidence of other important novel soil sensors for S100A8/A9: EMMPRIN, NPTNβ, MCAM and ALCAM .…”

“…1 After publication of the report by Hiratsuka et al, the RAGE was also included as a soil sensor for S100A8/A9. 2 We then found further evidence of other important novel soil sensors for S100A8/A9: EMMPRIN, 3 NPTNβ, 4 MCAM and ALCAM. 5,6 We named the proteins "S100 soil sensor receptors, abbreviated as SSSRs."…”

Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin

“…Such RAGE-derived responses could depend on certain conditions and situations between cellular components and ligand species/ concentrations. The exposure of keratinocytes to lower or higher concentrations of S100A8/A9 differentially activated the pro-survival or pro-apoptotic cascade via RAGE, respectively (8). However, the situation between RAGE (mRAGE, esRAGE or sRAGE) and its ligands remains unclear in healthy human skin in vivo.…”