DNMT1-mediated demethylation of lncRNA MEG3 promoter suppressed breast cancer progression by repressing Notch1 signaling pathway

Pan, Tingting; Ding, Haiwen; Jin, Le; Zhang, Shaobo; Wu, Duanqin; Pan, Wanwan; Dong, Menghao; Ma, Xiaopeng; Chen, Zhaolin

doi:10.1080/15384101.2022.2094662

Cited by 12 publications

(7 citation statements)

References 59 publications

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“…108 The findings of Zhu et al described, at least in part, a novel angiogenic signaling circuit (YAP1/Notch/NRP1) in breast malignancies, raising the possibility of linc-OIP5 as a target for therapy in breast tumor angiogenesis. 109 112 Large-scale -omics research has provided a wealth of information on lncRNA transcription in BC, suggesting that lncRNAs may be indicators for early recognition, assessment, and prognosis of BC. 113 As stated in prior studies, lncRNAs interact with miR-NAs, Notch components, and other genes to regulate the cascade and may be exploited as possible targets and prognostic markers.…”

Section: Lncrnas Positively Regulate Bc Through Notch Signalingmentioning

confidence: 99%

Non-coding RNAs Affect Breast Cancer Development Through the Notch Signaling Pathway: An Overview

Ahmadi,

Moqadami,

Khalaj-Kondori

et al. 2024

Gene Expr

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Breast cancer is the most prevalent malignancy and the leading cause of cancer-related death in women. Breast cancer is still an extremely difficult cancer to treat due to its significant metastasis. Mis-regulation of Notch signaling components such as Notch receptors/ligands and their interaction in breast cancer sparks tumor initiation, maintenance, and progression through induction of abnormal tumorigenesis while modulating vascular integrity, drug resistance, invasion, and migration. Numerous studies have shown that non-coding RNAs can regulate Notch signaling and accordingly impact breast cancer pathobiology. MiRNAs could regulate Notch signaling components directly or indirectly via sponging or suppressing other genes involved in the pathway. Further, lncRNAs interact with miRNAs and mRNAs, and lncRNA-miRNA-mRNA interaction networks function as substantial mediators in various pathways, including the Notch signaling pathway. Also, by targeting and sponging other genes, circRNAs could induce tumorigenic properties via the Notch signaling pathway. Due to the intricacy of human physiology, it is challenging for standard drugs to be effective, and cancer cells can develop resistance to treatment and have a significant self-renewal capacity. Moreover, because non-specific Notch signaling intervention targets both tumor cells and immune cells, it may have the reverse effect of regulating the formation of tumors. Thus, an in-depth understanding of the mechanisms could be useful in diagnosis, prognosis, and the development of novel medications that specifically target Notch signaling, improving the efficacy of cancer immunotherapy in the treatment of breast cancer. This review will discuss and clari-

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Section: Lncrnas Positively Regulate Bc Through Notch Signalingmentioning

confidence: 99%

Non-coding RNAs Affect Breast Cancer Development Through the Notch Signaling Pathway: An Overview

Ahmadi,

Moqadami,

Khalaj-Kondori

et al. 2024

Gene Expr

View full text Add to dashboard Cite

show abstract

“…LncRNAs mostly act as oncogenes in cancers. LncRNAs can interact with Notch or act as competing endogenous RNAs for miRNAs to indirectly induce Notch signaling in various cancers ( 212 – 214 ). Besides, other therapeutics targeting Notch are currently under investigation, such as natural products, virotherapy, and so on.…”

Section: Strategies For Cancer Therapymentioning

confidence: 99%

Notch signaling, hypoxia, and cancer

et al. 2023

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Notch signaling is involved in cell fate determination and deregulated in human solid tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia-induced factors (HIFs) and their downstream targets to promote tumorigenesis and cancer development. Recently, HIFs have been shown to trigger the Notch signaling pathway in a variety of organisms and tissues. In this review, we focus on the pro- and anti-tumorigenic functions of Notch signaling and discuss the crosstalk between Notch signaling and cellular hypoxic response in cancer pathogenesis, including epithelia-mesenchymal transition, angiogenesis, and the maintenance of cancer stem cells. The pharmacological strategies targeting Notch signaling and hypoxia in cancer are also discussed in this review.

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“…The tumor suppressor LncRNA MEG3 is regulated by DNMT1’s hypermethylation in breast cancer, resulting in down-regulation of its expression. When the demethylation reagent 5-AzadC is applied, the hypermethylation regulation of MEG3 by DNMT1 is significantly inhibited, and uninhibited MEG3 exerts its inhibitory effect on cancer through the inhibition of Notch1 signaling pathway ( 75 ). UXT, a putative member of the alpha pre-folded protein family, has recently been found to be involved in the regulation of methylation.…”

Section: Interactions Between Ncrnas and Other Epigenetic Modificatio...mentioning

confidence: 99%

“…With the knockdown of the upstream inhibitory target DNMT1, the highly expressed MEG3 shows high potential for cancer inhibition, including inhibiting cancer cell proliferation and promoting apoptosis, and inhibiting EMT through Notch1 signaling pathway. MEG3 can also effectively inhibit tumor growth in nude mice tumor grafts ( 75 ). Patients with up-regulation of LncRNA UCA1 often have a shorter survival time.…”

Section: Biological Effects Of Ncrnas Involved In Epigenetic Modifica...mentioning

confidence: 99%

Emerging roles of interactions between ncRNAs and other epigenetic modifications in breast cancer

Xie,

Gan,

Xue

et al. 2023

Front. Oncol.

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Up till the present moment, breast cancer is still the leading cause of cancer-related death in women worldwide. Although the treatment methods and protocols for breast cancer are constantly improving, the long-term prognosis of patients is still not optimistic due to the complex heterogeneity of the disease, multi-organ metastasis, chemotherapy and radiotherapy resistance. As a newly discovered class of non-coding RNAs, ncRNAs play an important role in various cancers. Especially in breast cancer, lncRNAs have received extensive attention and have been confirmed to regulate cancer progression through a variety of pathways. Meanwhile, the study of epigenetic modification, including DNA methylation, RNA methylation and histone modification, has developed rapidly in recent years, which has greatly promoted the attention to the important role of non-coding RNAs in breast cancer. In this review, we carefully and comprehensively describe the interactions between several major classes of epigenetic modifications and ncRNAs, as well as their different subsequent biological effects, and discuss their potential for practical clinical applications.

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DNMT1-mediated demethylation of lncRNA MEG3 promoter suppressed breast cancer progression by repressing Notch1 signaling pathway

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Cited by 12 publications

References 59 publications

Non-coding RNAs Affect Breast Cancer Development Through the Notch Signaling Pathway: An Overview

Non-coding RNAs Affect Breast Cancer Development Through the Notch Signaling Pathway: An Overview

Notch signaling, hypoxia, and cancer

Emerging roles of interactions between ncRNAs and other epigenetic modifications in breast cancer

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