Do ABO and Rhesus Blood Groups Affect Susceptibility to, and Prognosis of Ebola Virus Infection?

Conton, Brian; Gevao, Sahr M.; Sahr, Foday; Kargbo, Osman; Kamara, Philip; Bah, Abdulai Jawo; Massaquoi, Thomas; Idriss, Baimba; Sesay, Foday; Williams, A. Alun; Baker, S.; Nicol, Sylvester; Russell, James

doi:10.4172/2324-8955.1000165

Cited by 4 publications

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“…Blood type is a significant factor in disease prognosis, especially on viral diseases ( 32 ). In a study that examined the vulnerability and prognosis of ABO blood type to Ebola virus infection, type B showed a higher risk of infection and death ( 33 ). In recent decades, O blood group was more vulnerable to the influenza virus and that the H1 antibody titer after vaccination was higher in O blood type ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

The Probable Association between Blood Groups and Prognosis of COVID-19

Nasiri¹,

Khodadadi²,

Hajrezaei³

et al. 2021

ijph

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Background: We aimed to verify the association between blood group systems and prognosis of SARS-Cov-2 disease. Methods: In this cross-sectional study, 329 patients infected with SARS-Cov-2 diagnosed based on their COVID-19 RT-PCR results and chest CT scans, were enrolled in the study. These patients were admitted to Kamkar Arab Nia Hospital, Qom, Iran from March to June 2020. Their blood groups and RH were determined, and demographic characteristics and clinical signs of patients were recorded. The patients’ temperature and peripheral capillary oxygen saturation levels (SpO2) were measured. Finally, the duration of hospitalization, intubation, and death rate were also analyzed. Results: The results of the patients' blood group analysis were as follows: 129(39.2%) patients had A type, 66(20.1%) B type, 21(6.4%) AB type, and 113(34.3%) O type. Of 329 patients, 297 (90.3%) had Rh antigen. The dead cases were higher in O blood type at 13 cases (11.5%). Considering the positive and negative rhesus antigen, 31 (10.4%) and 1 (3.1%) were dead respectively, but the difference was not statically significant. As for the A group, the mean of admission duration (8.4±6.1 days) was not significantly different from the B group (8.8 ±7.2 days). AB group with a mean (7.4 ±4.4 days) was not significantly different from the O group (7.8 ± 5.4 days). There was no significant difference in the duration of hospitalization in RH patients, positive or negative. B blood group showed a significant association with the time interval to return to normal oxygen levels. Conclusion: Blood type was not associated with COVID-19 death rate, nor was it associated with admission duration. B blood group showed a significant association with the time interval to return to normal oxygen levels.

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Section: Discussionmentioning

confidence: 99%

The Probable Association between Blood Groups and Prognosis of COVID-19

Nasiri¹,

Khodadadi²,

Hajrezaei³

et al. 2021

ijph

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“…Other innate and adaptive factors can affect viral infection susceptibility or resistance. Previous researches have proved the potential role of ABO blood groups on a host's genetic susceptibility to various viral diseases such as influenza, Ebola, enteric viruses, and SARS-CoV infections (8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

The Novel Coronavirus SARS-CoV-2 Vulnerability Association with ABO/Rh Blood Types

et al. 2020

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Scan to discover online Background & Objective: Coronavirus disease 2019 (COVID-19) is the most recent emerging viral disease. Defining the epidemiological aspects and factors influencing the susceptibility of the patients to COVID-19 has been an ongoing struggle. In the present study, we have investigated the connection between ABO histo-blood group phenotypes and the COVID-19. Methods: This study was conducted on 397 patients with confirmed diagnoses of COVID-19 admitted to our center. Also, 500 individuals were selected to form the controls, all of whom had been disclosed to the same medical center in June 2019, before the onset of the outbreak. Results: Our results demonstrated ABO histo-blood phenotypes are correlated with patients' susceptibility to the infection. A higher rate of infection was observed among patients with the AB histo-blood group, while patients with the O histo-blood group have shown a lower rate of infection. The Rh blood group phenotype was not statistically significant in determining a patient's vulnerability. Conclusion: Similar to several previous studies about other viral diseases' association with ABO histo-blood groups, we have concluded that an individual's ABO histo-blood group phenotype and his/her susceptibility to COVID-19 are indeed connected. So far, only one research has been conducted about this association. Interestingly, while we observed a decreased vulnerability to the disease among patients with an O histo-blood group, we have reached discordant results regarding the increased susceptibility among individuals with an AB histo-blood group, unlike A histo-blood group in the previous study.

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Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

et al. 2021

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Aim: Many factors have been speculated to explain the COVID-19 complex clinical phenotype. Due to the inconsistent data published on blood groups and COVID-19, we conducted a study on Iranian patients to further assess this association. Materials & methods: This retrospective study was conducted on data collected from confirmed COVID-19 hospitalized patients during March and December 2020 in a referral hospital for COVID-19, 5 Azar Hospital, Gorgan, north of Iran. A total of 1554 confirmed COVID-19 cases were enrolled in the study with blood group (ABO and Rh), demographic, and clinical data available. Results: Of 1554 patients, 1267 and 287 cases had recovered and deceased (due to COVID-19) outcomes, respectively. Most of the cases had O+ (29.6%), the least number had AB- (0.5%), and most of the deceased cases had O+ blood types (31.4%). Logistic regression analysis revealed that groups A- and B- had higher and groups B+, AB+, O+ and O- had lower odds of death than the A+ group. Conclusion: This study indicates that blood types may be related to the clinical outcome of COVID-19. Further studies with a large cohort for multiple people are required to validate this association.

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Do ABO and Rhesus Blood Groups Affect Susceptibility to, and Prognosis of Ebola Virus Infection?

Cited by 4 publications

References 0 publications

The Probable Association between Blood Groups and Prognosis of COVID-19

The Probable Association between Blood Groups and Prognosis of COVID-19

The Novel Coronavirus SARS-CoV-2 Vulnerability Association with ABO/Rh Blood Types

Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

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