Do antibiotic prophylaxis and/or circumcision change periurethral uropathogen colonization and urinary tract infection rates in boys with VUR?

Gücük, Adnan; Burgu, Berk; Gökçe, İlker; Mermerkaya, Murat; Soygür, Tarkan

doi:10.1016/j.jpurol.2013.04.014

Cited by 17 publications

(2 citation statements)

References 20 publications

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“…In patients with VUR, circumcision was more effective than antibiotic prophylaxis alone or surgical correction in preventing UTIs and the occurrence of new DMSA abnormalities [23][24][25] . Similar results were seen in boys with posterior urethral valves 26 and infants with significant antenatal hydronephrosis 27 .…”

Section: Boys With Abnormal Urinary Tractmentioning

confidence: 94%

Abridged version: CUA guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants

Davé¹,

Afshar²,

Braga³

et al. 2017

CUAJ

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Section: Boys With Abnormal Urinary Tractmentioning

confidence: 94%

Abridged version: CUA guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants

Davé¹,

Afshar²,

Braga³

et al. 2017

CUAJ

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“…The bacteria adhere to the foreskin's mucosal surface and readily colonize it [49]. Since uropathogens are substantially lower by 3 weeks after circumcision of boys, it was suggested that by removing the foreskin MC eliminates the haven for organisms responsible for ascending UTI by changing it into an external skin surface [50][51][52]. For boys with hydronephrosis, MC is strongly recommended [53,54].…”

Section: Urinary Tract Infectionsmentioning

confidence: 99%

Evidence-based circumcision policy for Australia

Morris¹,

Katelaris²,

Blumenthal³

et al. 2022

JOMH

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The aim was (1) to perform an up-to-date systematic review of the male circumcision (MC) literature and (2) to determine the number of adverse medical conditions prevented by early MC in Australia. Searches of PubMed using “circumcision” with 39 keywords and bibliography searches yielded 278 publications meeting our inclusion criteria. Early MC provides immediate and lifetime benefits, including protection against: urinary tract infections, phimosis, inflammatory skin conditions, inferior penile hygiene, candidiasis, various STIs, and penile and prostate cancer. In female partners MC reduces risk of STIs and cervical cancer. A risk-benefit analysis found benefits exceeded procedural risks, which are predominantly minor, by approximately 200 to 1. It was estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime. An increase in early MC in Australia to mid-1950s prevalence of 85% from the current level of 18.75% would avoid 77,000 cases of infections and other adverse medical conditions over the lifetime for each annual birth cohort. Survey data, physiological measurements, and the anatomical location of penile sensory receptors responsible for sexual sensation indicate that MC has no detrimental effect on sexual function, sensitivity or pleasure. US studies found that early infant MC is cost saving. Evidence-based reviews by the AAP and CDC support early MC as a desirable public health measure. Although MC can be performed at any age, early MC maximizes benefits and minimises procedural risks. Parents should routinely be provided with accurate, up-to-date evidence-based information in an unbiased manner early in a pregnancy so that they have time to weigh benefits and risks of early MC and make an informed decision should they have a son. Parental choice should be respected. A well-trained competent practitioner is essential and local anaesthesia should be routinely used. Third party coverage of costs is advocated.

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