Do antihypertensive medications have an effect on dental implants? A systematic review

Mishra, Sunil Kumar; Sonnahalli, Nithin Kumar; Chowdhary, Ramesh

doi:10.1007/s10006-023-01167-1

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…All implants were fitted with an overdenture and occluded against an upper denture, which, due to the reduced contact forces when compared to natural teeth, is favorable for success [23]. Additionally, Mishra et al 2023 [48], in their systematic review, aimed to compare the clinical outcomes of dental implants in individuals using antihypertensive medications versus non-users. The databases suggested by studies involved a total of 959 patients, primarily using renin-angiotensin system (RAS) inhibitors.…”

Section: Survival Outcomesmentioning

confidence: 99%

“…Despite these positive outcomes, the evidence remains limited and heterogeneous, particularly regarding the specific types of antihypertensive medications used. As such, more targeted research is necessary to isolate the effects of different antihypertensive drugs on dental implant success and stability [48].…”

Section: Survival Outcomesmentioning

confidence: 99%

“…Conversely, studies with a low risk of bias, such as Carr et al, 2019 [15], and Malm et al, 2021 [31], provide stronger evidence and add more weight to the systematic review's findings. The mixed levels of bias underscore the necessity for cautious interpretation of the overall evidence and highlight the importance of considering bias in the aggregation of study results [48].…”

Section: Survival Outcomesmentioning

confidence: 99%

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The Effect of Antihypertensive Agents on Dental Implant Stability, Osseointegration and Survival Outcomes: A Systematic Review

Jones,

Khan,

Thompson

et al. 2024

Surgeries

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Antihypertensive agents are commonly prescribed to manage hypertension and are known to be beneficial for bone formation and remodeling. The aim of this systematic review was to assess the impact that antihypertensive agents have on dental implant stability, osseointegration, and survival outcomes. A review of the literature was conducted using articles from 11 data sources. PRISMA guidelines were followed, and a PICO question was constructed. The search string “Antihypertensive* AND dental implant* AND (osseointegration OR stability OR survival OR success OR failure)” was used for all data sources where possible. The Critical Appraisal Skills Programme (CASP) was used for study appraisal, including the risk of bias. The search resulted in 7726 articles. After selection according to eligibility criteria, seven articles were obtained (one randomized control trial, two prospective cohort studies, three retrospective cohort studies, and a case control study). Five papers investigated the effects of antihypertensive agents on primary stability, but there were discrepancies in the method of assessment. Inhibition of the renin–angiotensin–aldosterone system was linked to higher primary stability. Secondary stability was usually higher than primary stability, but it is unknown if antihypertensive agents caused this. Survival outcomes were increased with certain antihypertensive agents. It is possible that inhibition of the renin–angiotensin–aldosterone system may lead to greater bone mineral density, improved primary stability, and improved survival outcomes although the effects on osseointegration are unknown. However, more research is needed to confirm this theory.

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Section: Survival Outcomesmentioning

confidence: 99%

Section: Survival Outcomesmentioning

confidence: 99%

Section: Survival Outcomesmentioning

confidence: 99%

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The Effect of Antihypertensive Agents on Dental Implant Stability, Osseointegration and Survival Outcomes: A Systematic Review

Jones,

Khan,

Thompson

et al. 2024

Surgeries

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“…In addition, reviews of this type cannot be completed without pre-existing reviews, and they do not include information regarding epidemiological associations not examined in the included reviews [9]. Another review, but a systematic one, was also published recently, which evaluated the possible effects of the condition on dental implants [10]. Nevertheless, the electronic search was restricted to two databases, and the authors limited the inclusion criteria to studies that reported the type of antihypertensive medication that was used, resulting in only three studies being included.…”

Section: Introductionmentioning

confidence: 99%

Hypertension and Dental Implants: A Systematic Review and Meta-Analysis

Hamadé,

El-Disoki,

Chrcanovic

2024

JCM

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Purpose: The aim of the present systematic review was to investigate the influence of hypertension on the dental implant failure rate. Methods: An electronic search was undertaken in four databases, plus a manual search of journals. The I2 statistic was used to check heterogeneity and the inverse-variance method was used for the meta-analysis. The estimate of relative effect for dichotomous outcome was expressed as an odds ratio (OR). Results: The review included 24 publications. There were 4874 implants (257 failures) placed in hypertensive patients and 16,192 implants (809 failures) placed in normotensive patients. A pairwise meta-analysis showed that implants in hypertensive patients did not have a higher risk of failure than implants placed in normotensive patients (OR 1.100, p = 0.671). The log OR of implant failure between hypertensive and normotensive patients did not significantly change with the follow-up time (p = 0.824). Conclusions: This review suggests that implants in hypertensive patients do not present higher odds of failure in comparison to normotensive patients. However, further research on this topic, with the use of more rigorous criteria to diagnose patients as being hypertensive, as well as clearer information about the pharmacological management of the condition in the patients, is recommended.

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“…In addition, several drugs applied as treatment, such as beta blockers, could cause dry mouth, which can increase the risk of dental implant failure [15,16].…”

Section: Introductionmentioning

confidence: 99%

Full-Arch Implant-Prosthetic Rehabilitation in Patients Affected by Hypertension: A Randomized Clinical Trial at 7 Years Follow-Up

Capparè,

Nagni,

D’Orto

et al. 2023

Applied Sciences

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The aim of this clinical study was to investigate and compare implant survival rates, marginal bone loss, and surgical and prosthetic complications of healthy patients and subjects affected by hypertension receiving full-arch implant-prosthetic rehabilitation. From January 2016 to November 2016, patients affected by total edentulism of one or both arches or severe impairment of residual teeth who needed full-arch implant-prosthetic rehabilitation and who had the absence of any systemic diseases or the presence of hypertension as a single pathology were randomly selected. According to the inclusion criteria, 39 patients were enrolled for this study. The sample was divided into two groups: A total of 18 patients were included in Group A (healthy patients), and 21 patients were included in Group B (patients affected by hypertension). No statistically significant difference in implant survival rates, marginal bone loss, and prosthetic complications were observed between Group A and Group B. Except for variable bleeding, the results of the Pearson’s chi-square test and z-test at a 99% confidence level suggest that there is no statistically significant difference in clinical complications between the groups. Within the limitations of this study, full-arch implant-prosthetic rehabilitation could be a feasible option for treating patients with hypertension, provided that hypertension is compensated and controlled.

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Do antihypertensive medications have an effect on dental implants? A systematic review

Cited by 7 publications

References 32 publications

The Effect of Antihypertensive Agents on Dental Implant Stability, Osseointegration and Survival Outcomes: A Systematic Review

The Effect of Antihypertensive Agents on Dental Implant Stability, Osseointegration and Survival Outcomes: A Systematic Review

Hypertension and Dental Implants: A Systematic Review and Meta-Analysis

Full-Arch Implant-Prosthetic Rehabilitation in Patients Affected by Hypertension: A Randomized Clinical Trial at 7 Years Follow-Up

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