Do Antioxidant Vitamins Prevent Exercise-Induced Muscle Damage? A Systematic Review

Martínez‐Ferrán, María; Sanchís-Gomar, Fabián; Lavie, Carl J.; Lippi, Giuseppe; Pareja‐Galeano, Helios

doi:10.3390/antiox9050372

Cited by 22 publications

(32 citation statements)

References 66 publications

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“…Thus, while Nie and Lin [ 41 ] noted the reduced release of the muscle damage marker CK, both investigations were unsuccessful in reducing MS [ 36 ]. The findings of a review of the impacts of both VitE and VitC on exercise-induced muscle damage indicated that acute SUP may protect against muscle damage and improve recovery [ 45 ]. Despite this, we observed reductions in DOMS in those studies following a chronic SUP protocol before and after eccentric exercise.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review

et al. 2021

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Muscle damage induced by exercise may have several consequences such as delayed-onset muscle soreness, a side-effect of the release of free radicals during oxidative stress. To mitigate the oxidative stress cascade, the oral intake of antioxidants has been assessed by several research groups. This review examines whether supplementation with vitamin C and/or vitamin E is able to prevent or attenuate delayed-onset muscle soreness after eccentric exercise. The PubMed, Web of Science, Medline, and Embase databases were searched to identify studies meeting the inclusion criteria: primary randomized control trials, healthy male and female participants aged 16–80 years, and an intervention consisting of the intake of vitamin C and/or vitamin E without other supplements plus a controlled eccentric exercise regimen. Further requirements were the measurement of muscle soreness or markers of delayed-onset muscle soreness. All original full-text articles in English or translated into English published from January 2000 to June 2020 were considered for this review. Fourteen studies were finally identified, including 280 participants, 230 men, and 50 women aged 16–30 years. All participants were healthy individuals with different starting levels of physical activity. Supplementation was acute in two studies and chronic in 12, and its consisted of vitamin C in eight studies, vitamin E in two studies, and both in four studies. Only in 3 of the 14 studies was muscle soreness found to be significantly reduced in response to vitamin C and/or vitamin E supplementation at all time points when compared to the placebo group. Despite some studies showing the beneficial effects of chronic supplementation with these vitamins on muscle soreness manifesting 24–72 hours after eccentric exercise, the evidence is so far insufficient to confirm that the intake of antioxidant vitamins is able to minimize delayed-onset muscle soreness in this context.

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Section: Discussionmentioning

confidence: 99%

Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review

et al. 2021

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“…It should be noted that some studies have evaluated the effects of vitamin E on the recovery of muscle contraction force following exercise. Overall, the available evidence on the effects of vitamin E alone or combined with vitamin C against exercise-induced muscle damage are not conclusive [ 3 ].…”

Section: Effects Vitamin E and C Supplementation: Environment Andmentioning

confidence: 99%

“…It has been estimated by the American College of Sports Medicine that approximately 50% of athletes take vitamin supplements with the goal of staying fit and improving endurance [ 1 , 2 ]. Recently, antioxidant supplementation has received attention among athletic populations as a possible method to reduce muscle damage incurred during exercise [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation

Higgins

Izadi

Kaviani

2020

IJERPH

125

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Antioxidant supplementation, including vitamin E and C supplementation, has recently received recognition among athletes as a possible method for enhancing athletic performance. Increased oxidative stress during exercise results in the production of free radicals, which leads to muscle damage, fatigue, and impaired performance. Despite their negative effects on performance, free radicals may act as signaling molecules enhancing protection against greater physical stress. Current evidence suggests that antioxidant supplementation may impair these adaptations. Apart from athletes training at altitude and those looking for an immediate, short-term performance enhancement, supplementation with vitamin E does not appear to be beneficial. Moreover, the effectiveness of vitamin E and C alone and/or combined on muscle mass and strength have been inconsistent. Given that antioxidant supplements (e.g., vitamin E and C) tend to block anabolic signaling pathways, and thus, impair adaptations to resistance training, special caution should be taken with these supplements. It is recommended that athletes consume a diet rich in fruits and vegetables, which provides vitamins, minerals phytochemicals, and other bioactive compounds to meet the recommended intakes of vitamin E and C.

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“…Accordingly, it has been proposed that the intake of antioxidants could prevent exercise-induced muscle damage. In 2020, a systemic review concluded that there is some evidence of a protective effect of vitamin C and/or vitamin E supplementation against exercise-induced muscle damage (Martinez-Ferran et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of work-related musculoskeletal disorders among Egyptian printing workers evidenced by using serum biomarkers of inflammation, oxidative stress, muscle injury, and collagen type I turnover

Mourad

2020

Toxicol Ind Health

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Objective: Printing workers experience a high rate of musculoskeletal disorders (MSDs). This study aims to determine the prevalence of MSDs, estimate serum biomarkers denoting musculoskeletal tissue changes, and determine some individual risk factors for MSDs among Egyptian printing workers. Methods: Eighty-five male printing workers and 90 male administrative employees (control group) were recruited from a printing press in Giza. A validated version of the standardized Nordic questionnaire was used. Serum biomarkers of inflammation (interleukin (IL)-1α, IL-1β, IL-6, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP)), cell stress or injury (malondialdehyde (MDA) and creatine kinase skeletal muscle (CK-MM)), and collagen metabolism (collagen-I carboxy-terminal propeptide (PICP) and type-I collagen cross-linked C-telopeptide (CTx)) were measured for all participants. Results: This study showed a significant ( p < 0.001) prevalence of the musculoskeletal symptoms (76.5%) and significant ( p < 0.001) elevation in the levels of all measured biomarkers among the printing workers (means ± SD: IL-1α = 1.55 ± 0.9, IL-1β = 1.53 ± 0.87, IL-6 = 1.55 ± 0.85, TNF-α = 4.9 ± 2.25, CRP = 6.78 ± 3.07, MDA = 3.41 ± 1.29, CK-MM = 132.47 ± 69.01, PICP = 103.48 ± 36.44, and CTx = 0.47 ± 0.16) when compared with their controls (prevalence: 34.4%; means ± SD: IL-1α = 0.88 ± 0.61, IL-1β = 0.96 ± 0.72, IL-6 = 1.03 ± 0.75, TNF-α = 2.56 ± 1.99, CRP = 2.36 ± 1.1, MDA = 0.85 ± 0.21, CK-MM = 53.48 ± 33.05, PICP = 56.49 ± 9.05, and CTx = 0.31 ± 0.06). Also, significant ( p < 0.001) positive strong associations were observed between age, body mass index (BMI), and the duration of employment with all measured biomarkers, where all correlation coefficients were >0.7. Conclusion: Printing workers suffer a high prevalence of work-related MSDs that might be related to some individual factors (age, BMI, and duration of employment). Consequently, preventive ergonomic interventions should be applied. Further studies should be done to elucidate the link between tissue changes and detected biomarkers to follow the initiation and progression of MSDs and study the effectiveness of curative interventions.

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Do Antioxidant Vitamins Prevent Exercise-Induced Muscle Damage? A Systematic Review

Cited by 22 publications

References 66 publications

Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review

Supplementation with Vitamins C and E and Exercise-Induced Delayed-Onset Muscle Soreness: A Systematic Review

Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation

Prevalence of work-related musculoskeletal disorders among Egyptian printing workers evidenced by using serum biomarkers of inflammation, oxidative stress, muscle injury, and collagen type I turnover

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