Do antioxidants still have a role in the prevention of human cancer?

Rock, Cheryl L.

doi:10.1007/s11912-001-0082-8

Cited by 12 publications

(4 citation statements)

References 49 publications

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“…Se is well known trace element which is involved in integral parts of antioxidant enzymes such as glutathione peroxidase [39]. In literature, significantly low serum level of Se had been detected in patients with prostate cancer [40,41].…”

Section: Discussionmentioning

confidence: 99%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p < 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p < 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.

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Section: Discussionmentioning

confidence: 99%

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Özgür¹,

Demır²,

Doğan³

et al. 2013

JCT

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“…However, most of the damage caused by ROS is restored by internal surveillance and repair systems. 61 On the other hand, ROS can play important roles in a variety of normal processes in the body and are considered as endogenous mitogenic factors that may also activate NF-kB and other transcription factors into the nucleus. 62 One of the chemoprevention mechanisms of phenolic compounds is associated to their scavenging properties of deleterious reactive species (e.g., superoxide anion, hydroxyl radical, singlet oxygen, nitric oxide, and peroxynitrite).…”

Section: G Antioxidant and Anti-inflammatory Effectsmentioning

confidence: 99%

New insights on the anticancer properties of dietary polyphenols

et al. 2006

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Cancer, one of the major causes of death across the world, has shown to be a largely preventable disease, highly susceptible to modulation by dietary factors. Phenolic compounds, abundant in vegetables and fruits ubiquitous in diet, were described to play an important role as chemopreventive agents. Since conventional therapeutic and surgical approaches have not been able to control the incidence of most cancer types, the development of chemopreventive strategies is an urgent priority in public health. The current diet phenolic intake is often insufficient to protect from mutagens (either exogenous or endogenous), which leads to the need for dietary supplementation as an alternative approach. Research efforts are placing increasing emphasis on identifying the biological mechanisms and in particular the signal transduction pathways related to the chemopreventive activities of these compounds. These effects are believed to occur by the regulation of signaling pathways such as nuclear factor-kB (NF-kB), activator protein-1 (AP-1) or mitogen-activated protein kinases (MAPK). Dietary polyphenols can exert their effects on these pathways separately or sequentially and in addition the occurrence of crosstalk between these pathways cannot be overlooked. By modulating cell signaling pathways, polyphenols activate cell death signals and induce apoptosis in precancerous or malignant cells resulting in the inhibition of cancer development or progression. However, regulation of cell signaling pathways by dietary polyphenols can also lead to cell proliferation/survival or inflammatory responses due to increased expression of several genes. The present review summarizes the most recent advances providing new insights into the molecular mechanisms underlying the promising anticarcinogenic activity of dietary polyphenols. ß

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“…ROS can cause oxidative damage to proteins, DNA, and RNA, as well as oxidation of fatty acids in cell membranes which in turn can increase the risk of mutations and promote carcinogenesis [51–54]. However, under physiological conditions, most of the injuries caused by ROS are restored by the body's antioxidant repair system [55]. Flavonoids have been shown to exert a direct scavenging effect on ROS by donating hydrogen atom [56].…”

Section: Introductionmentioning

confidence: 99%

Polyphenols as Key Players for the Antileukaemic Effects of Propolis

Abubakar

Abdullah

Sulaiman

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Propolis (a bee product) which has a long history of medicinal use by humans has attracted a great deal of research interest in the recent time; this is due to its widely reported biological activities such as antiviral, antifungal, antibacterial, anti-inflammatory, antioxidant, and anticarcinogenic properties. Crude form of propolis and its phenolic contents have both been reported to exhibit antileukaemic effects in various leukaemia cell lines. The ability of the polyphenols found in propolis to arrest cell cycle and induce apoptosis and differentiation in addition to inhibition of cell growth and proliferation makes them promising antileukaemic agents, and hence, they are believed to be a key to the antileukaemic effects of propolis in different types of leukaemia. This paper reviews the molecular bases of antileukaemic activity of both crude propolis and individual polyphenols on various leukaemia cell lines, and it indicates that propolis has the potential to be used in both treatment and prevention of leukaemia. This however needs further evaluation by in vitro, in vivo, and epidemiological studies as well as clinical trials.

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Do antioxidants still have a role in the prevention of human cancer?

Cited by 12 publications

References 49 publications

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

Plasma Concentrations of Some Trace Element and Heavy Metals in Patients with Metastatic Colon Cancer

New insights on the anticancer properties of dietary polyphenols

Polyphenols as Key Players for the Antileukaemic Effects of Propolis

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