Do arginine metabolites have a role in periodontitis due to smoking? A new perspective

Yilmaz, Melis; Yay, Ekin; Atalay, Nur; Balcı, Nur; Kurgan, Şivge; Toygar, Hilal Uslu; Serdar, Muhittin

doi:10.1111/odi.14448

Cited by 4 publications

(3 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The two examiners were trained on 10 non-study volunteers for calibration. 31 The probing depth values demonstrated good reproducibility, assessed by inter-examiner analysis (κ = 0.892) before the study. The reproducibility assessment showed that the mean of repeated probing measurements was within 1 mm for 90% of the sites.…”

Section: Clinical Assessment Of Periodontal Diseasementioning

confidence: 84%

See 1 more Smart Citation

Parkinson's disease is positively associated with periodontal inflammation

Yilmaz

Yay

Balcı

et al. 2023

Journal of Periodontology

Self Cite

View full text Add to dashboard Cite

BackgroundParkinson's disease (PA) affects 1% of the global population above 60 years. PA pathogenesis involves severe neuroinflammation that impacts systemic and local inflammatory changes. We tested the hypothesis that PA is associated with periodontal tissue inflammation promoting a greater systemic inflammatory burden.MethodsWe recruited 60 patients with Stage III, Grade B periodontitis (P) with and without PA (n = 20 for each). We also included systemically and periodontally healthy individuals as controls (n = 20). Clinical periodontal parameters were recorded. Serum, saliva, and gingival crevicular fluid (GCF) samples were collected to measure the inflammatory and neurodegenerative targets (YKL‐40, fractalkine, S100B, alpha‐synuclein, tau, vascular cell adhesion protein‐1 (VCAM‐1), brain‐derived neurotrophic factor (BDNF), neurofilament light chain (NfL).ResultsParkinson's patients in this study had mild to moderate motor dysfunctions, which did not prevent them from performing optimal oral hygiene control. Periodontal parameters and GCF volume were significantly higher in the P and P+PA groups than in the control group. PA was associated with significantly increased bleeding on probing (BOP) compared to P‐alone (p < 0.05), while other clinical parameters were similar between P and P+PA groups. In saliva and serum, YKL‐40 levels were higher in the P+PA group than in P and C groups (p < 0.001). GCF NfL levels from shallow sites were significantly higher in the P+PA group compared to the C group (p = 0.0462). GCF S100B levels from deep sites were higher in the P+PA group than in healthy individuals (p = 0.0194).ConclusionThe data suggested that PA is highly associated with increased periodontal inflammatory burden—bleeding upon probing and inflammatory markers—in parallel with PA‐related neuroinflammation.

show abstract

Section: Clinical Assessment Of Periodontal Diseasementioning

confidence: 84%

“…All measurements were performed using a periodontal probe with William's markings by two calibrated periodontists (E.Y., M.Y.). The two examiners were trained on 10 non‐study volunteers for calibration 31 . The probing depth values demonstrated good reproducibility, assessed by inter‐examiner analysis (κ = 0.892) before the study.…”

Section: Methodsmentioning

confidence: 99%

Parkinson's disease is positively associated with periodontal inflammation

Yilmaz

Yay

Balcı

et al. 2023

Journal of Periodontology

Self Cite

View full text Add to dashboard Cite

show abstract

“…There was no single metabolite that was measured in all four publications. Two studies analyzed arginine and its methylated derivatives: one showed no significantly affected metabolites [ 52 ], while the other showed two significantly affected compounds (out of six measured) [ 51 ]. Another study performed by LC-MS/MS revealed 28 metabolites (out of 51 measured) that were significantly increased in periodontitis [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

The Metabolic Footprint of Systemic Effects in the Blood Caused by Radiotherapy and Inflammatory Conditions: A Systematic Review

Jelonek,

Mrowiec,

Gabryś

et al. 2023

Metabolites

View full text Add to dashboard Cite

Response to radiotherapy (RT) includes tissue toxicity, which may involve inflammatory reactions. We aimed to compare changes in metabolic patterns induced at the systemic level by radiation and inflammation itself. Patients treated with RT due to head and neck cancer and patients with inflammation-related diseases located in the corresponding anatomical regions were selected. PubMed and Web of Science databases were searched from 1 January 2000 to 10 August 2023. Twenty-five relevant studies where serum/plasma metabolic profiles were analyzed using different metabolomics approaches were identified. The studies showed different metabolic patterns of acute and chronic inflammatory diseases, yet changes in metabolites linked to the urea cycle and metabolism of arginine and proline were common features of both conditions. Although the reviewed reports showed only a few specific metabolites common for early RT response and inflammatory diseases, partly due to differences in metabolomics approaches, several common metabolic pathways linked to metabolites affected by radiation and inflammation were revealed. They included pathways involved in energy metabolism (e.g., metabolism of ketone bodies, mitochondrial electron transport chain, Warburg effect, citric acid cycle, urea cycle) and metabolism of certain amino acids (Arg, Pro, Gly, Ser, Met, Ala, Glu) and lipids (glycerolipids, branched-chain fatty acids). However, metabolites common for RT and inflammation-related diseases could show opposite patterns of changes. This could be exemplified by the lysophosphatidylcholine to phosphatidylcholine ratio (LPC/PC) that increased during chronic inflammation and decreased during the early phase of response to RT. One should be aware of dynamic metabolic changes during different phases of response to radiation, which involve increased levels of LPC in later phases. Hence, metabolomics studies that would address molecular features of both types of biological responses using comparable analytical and clinical approaches are needed to unravel the complexities of these phenomena, ultimately contributing to a deeper understanding of their impact on biological systems.

show abstract

Smokeless tobacco and periodontitis: A systematic review with meta‐analysis

Quadri,

Kamel,

Nayeem

et al. 2024

J of Periodontal Research

View full text Add to dashboard Cite

AimThe present systematic review with meta‐analysis aimed to investigate the global association between smokeless tobacco (SLT) use and periodontitis, considering significant effect size variation based on the income levels of countries.MethodsWe searched seven databases to identify studies that assessed the prevalence of periodontitis in adult SLT users compared to non‐users. The quality of studies was evaluated using the 10‐item risk‐of‐bias tool, and publication bias was addressed through the trim‐and‐fill method. Sensitivity analysis utilized the leave‐one‐out approach. Meta‐analysis and meta‐regression, stratified by country income, SLT type, and smoking status, employed robust variance estimation.ResultsFrom an initial pool of 484 studies, 29 studies met the selection criteria and were subjected to qualitative synthesis. Subsequently, data from 19 studies were included in the meta‐analysis. SLT users exhibited a nearly threefold greater likelihood of periodontitis compared to non‐users (OR = 2.99; 95% CI: 2.10, 4.27; p < .01). The pooled estimate did not vary significantly based on the type of SLT used or concurrent smoking. However, the odds of periodontitis varied according to the economic level of the country; the pooled estimate was higher in high‐income countries (OR = 1.69; 95% CI: 1.20, 2.37; p < .01) and even higher in lower‐middle‐income and lower‐income countries (OR = 3.91; 95% CI: 2.66, 5.77; p < .01).ConclusionsSmokeless tobacco users have a higher likelihood of developing periodontitis. This study underscores global disparities in the SLT–periodontitis relationship, highlighting the need for targeted interventions, particularly in economically challenged areas where SLT use is largely unregulated.

show abstract

Do arginine metabolites have a role in periodontitis due to smoking? A new perspective

Cited by 4 publications

References 64 publications

Parkinson's disease is positively associated with periodontal inflammation

Parkinson's disease is positively associated with periodontal inflammation

The Metabolic Footprint of Systemic Effects in the Blood Caused by Radiotherapy and Inflammatory Conditions: A Systematic Review

Smokeless tobacco and periodontitis: A systematic review with meta‐analysis

Contact Info

Product

Resources

About