2014
DOI: 10.1111/tri.12382
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Do Asian renal transplant patients need another mycophenolate mofetil dose compared with Caucasian or African American patients?

Abstract: Summary Mycophenolate mofetil (MMF) is used to prevent acute rejection following solid organ transplantation in transplant centers all over the world. Patients from different ethnic backgrounds are treated with this drug, for which therapeutic drug monitoring (TDM) has not become the standard of practice in most centers. Whether or not some ethnic groups require a different MMF dose has been a topic of debate in recent years. In this review, it is shown that Asian patients, compared with Caucasian patients, wi… Show more

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Cited by 36 publications
(23 citation statements)
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References 96 publications
(132 reference statements)
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“…Genetic variations in drug metabolism have been reported for African Americans in the United States, as well as the possibility of the variation in a gene involved in the coagulation cascade contributing to increased acute rejection in African Americans . In contrast, studies of Asian recipients have suggested differences in the pharmacokinetics of mycophenolate compared to Caucasian patients given similar doses …”
Section: Discussionmentioning
confidence: 99%
“…Genetic variations in drug metabolism have been reported for African Americans in the United States, as well as the possibility of the variation in a gene involved in the coagulation cascade contributing to increased acute rejection in African Americans . In contrast, studies of Asian recipients have suggested differences in the pharmacokinetics of mycophenolate compared to Caucasian patients given similar doses …”
Section: Discussionmentioning
confidence: 99%
“…Asian patients have a higher MPA exposure than do Caucasian or African American patients with a comparable MMF dose. For this reason, MMF dose in Asian transplant recipients may be reduced to 20% to 46% lower than in Caucasian or African American patients [ 15 18 ]. In this study, the average dose of both MMF and EC-MPS (1.4 g and 0.8 g, respectively) was lower than in Western countries.…”
Section: Discussionmentioning
confidence: 99%
“…In this study the approach appears well designed; however, ethnic differences could influence MPA pharmacokinetics, create a bias and generate nomograms that cannot be used for other ethnic groups. It appears that with the same dosage, MPA systemic exposure is higher in Asian renal transplant patients than in Caucasians and American-Africans [61].…”
Section: Discussionmentioning
confidence: 92%