Do biomarkers have predictive value in the treatment modality of the patients diagnosed with bowel obstruction?

Abstract

OBJECTIVES: This study aimed to investigate the ability of the biomarkers to predict the surgery treatment and mortality in patients above 18 years of age who were hospitalized with the diagnosis of bowel obstruction from the emergency department.METHODS: This is a 2-year retrospective study. The patients' demographic data, laboratory parameters on admission to emergency department, treatment modalities, and the length of hospital stay were recorded. Patients were divided into two groups: conservative and surgical treatment. Statistical analysis was performed to investigate the value of biomarkers in predicting mortality and the need for surgery. Data were analyzed using IBM SPSS version 22.RESULTS: A total of 179 patients were included in this study. Of these, 105 (58.7%) patients were treated conservative and 74 (41.3%) were treated operatively. The elevated procalcitonin (PCT) level, C-reactive protein, blood urea nitrogen-to-albumin ratio, and lactate-to-albumin ratio were significantly correlated with surgical treatment, length of hospital stay, and mortality. procalcitonin threshold value of 0.13 ng/mL was able to predict the need for surgical treatment, with a sensitivity of 79% and a specificity of 70.3%. Procalcitonin threshold value of 0.65 ng/mL was able to predict the mortality rate of the patients, with a sensitivity of 92.9% and a specificity of 78.1%.CONCLUSIONS: Biomarkers, especially procalcitonin, may be useful in bowel obstruction treatment management and may predict mortality.

Evaluation of the relationship between Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) score and treatment modality and mortality in patients with ileus

“…A review of the studies in the relevant literature revealed that high CRP levels were correlated with the duration of hospitalization and were a predictive factor in determining in-hospital mortality. [15,16] In the present study, high CRP was associated with mortality, consistent with the literature. Yoon and Lee reported that high neutrophil levels were predictive factors in determining in-hospital mortality, whereas lymphocyte levels were not effective in predicting mortality in the same study.…”

“…Studies performed on patients who underwent surgery for small bowel obstruction showed that low albumin levels were correlated with the duration of hospitalization and were a risk factor for mortality. [16,17] In the present study, an association between low albumin levels and mortality was identified. In addition, this is possibly the first study to evaluate the relationship between HALP score and mortality in patients with ileus.…”

“…In a study investigating the effectiveness of biomarkers in determining mortality and treatment modality in patients with ileus in the emergency department, high CRP and low albumin levels were significant in predicting the surgical treatment modality. [16] Lapsekili and Bilge examined the parameters used to determine the treatment modality in patients with intestinal obstruction and reported that neutrophil and lymphocyte levels were not significant when comparing surgical and conservative treatment groups. [18] In the present study, neutrophil and albumin levels were not significant in predicting surgical treatment modality, whereas low lymphocyte levels, low HALP scores, and high CRP levels were significant.…”