Do blood groups have effect on prognosis of patients undergoing radical cystectomy?

Süer, Evren; Özcan, Cihat; Gökçe, İlker; Gülpınar, Ömer; Göğüş, Çağatay; Türkölmez, Kadír; Baltacı, Sümer; Bedük, Yaşar

doi:10.1007/s11255-014-0698-x

Cited by 12 publications

(7 citation statements)

References 22 publications

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“…In urothelial bladder carcinoma patients after radical cystectomy, the blood type B was associated with a greater likelihood of lymphovascular invasion and positive soft tissue margins, and blood type B patients showed a significantly higher urothelial bladder carcinoma-related mortality than those with the blood types O and AB (48). By other researchers, the ABO blood group was not associated with the prognosis of bladder cancer patients who underwent radical cystectomy (49).…”

Section: Blood Group or (95% Ci)mentioning

confidence: 84%

ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity

et al. 2018

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The aim of the present study was to assess the ABO blood group polymorphism association with prostate, bladder and kidney cancer, and longevity. The following data groups were analyzed: Prostate cancer (n=2,200), bladder cancer (n=1,530), renal cell cancer (n=2,650), oldest-old (n=166) and blood donors (n=994) groups. The data on the ABO blood type frequency and odds ratio in prostate cancer patients revealed a significantly higher blood group B frequency (P<0.05); the pooled men and women, separate men bladder cancer risk was significantly associated with the blood group B (P<0.04); however, no such association was identified in the female patients. The blood group O was observed to have a significantly decreased risk of bladder cancer for females (P<0.05). No significance for the ABO blood group type in the studied kidney cancer patients was identified. A comparison of the oldest-old and blood donor groups revealed that blood group A was significantly more frequent and blood type B was significantly rarer in the oldest-olds (P<0.05). The results of the present study indicated that blood type B was associated with the risk of prostate and bladder cancer, and could be evaluated as a determinant in the negative assocation with longevity. Blood types O and A may be positive factors for increasing the oldest-old age likelihood. The clustering analysis by the ABO type frequency demonstrated that the oldest-olds comprised a separate cluster of the studied groups.

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Section: Blood Group or (95% Ci)mentioning

confidence: 84%

ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity

et al. 2018

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“…The sample size varied from 103 to 7906, reaching a total of 15,204 participants. All included studies reported the ABO blood type of participants, and 10 included studies reported the treatment of participants and 4 studies [ 22 , 24 , 26 , 27 ] reported the data on Rhesus blood group system. The main study characteristics are shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Based on 4 studies [ 22 , 25 – 27 ] reported BC patients treated with RC and measured the blood type non-O (ref: O) on prognosis of included patients, the outcomes of pooled results did not demonstrate an influence of non-O blood group on disease recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS) of the patients treated with RC for BC. What’s more, the blood type non-O has no association with an advanced pathologic tumor stage and lymph node metastasis in according to Engle’s study.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of prognosis of ABO blood group and rhesus factor on outcomes in patients with bladder cancer

Yan

2022

Medicine

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Background: Bladder cancer (BC) is the 10th most common malignancy worldwide, and some studies reported that ABO blood type or/and rhesus factor has been identified as a prognostic oncologic marker for patients with BC. We carried out a systematic review to assess the prognosis of ABO blood group and rhesus factor on outcomes in patients with bladder cancer. Methods: We searched databases through February 2022 for studies assessing blood group on outcomes in patients with bladder cancer. Results: We included ten studies with 15,204 participants. We found that blood type A is relevant to non-muscle-invasive BC patients treated with transurethral resection of bladder tumor and blood type B patients have a lower incidence of disease recurrence and progression. Blood type O and non-O blood type have not been found to be related to disease recurrence. However, in multivariable analyses, blood type O and non-O blood type are associated with cancer-specific mortality (CSM). Other than that, blood type B doesn’t have statistical significance for BC patients accepted radical cystectomy (RC). The same results showed in blood type AB non-muscle-invasive bladder cancer patients treated with RC. Conclusions: Our study confirmed that a particular association of blood type for prognosis of patients with BC, and ABO blood group antigen expression can be suitable biomarkers for BC. We also found that rhesus factor has no impact on prognosis of BC patients.

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“…They found no significant difference in stage, lymph node status, histological subtype, disease-specific and overall survival rates. 14 The impact of blood group in muscle-invasive disease in patients receiving chemotherapy was also shown to be not helpful in prognosis. 15 Hence, further consideration of blood group in prognosis and risk assessment even in non-muscle disease is of questionable value.…”

Section: Discussionmentioning

confidence: 99%

The relationship between ABO blood group type and tumor grade, stage, recurrence and progression in transitional cell carcinoma of the bladder: A preliminary report

Tiwari

Garg

Nayak

et al. 2019

Journal of Clinical Urology

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Objectives: ABO blood grouping is a well-proven prognostic factor in many malignancies. This study aims to study the association and impact of ABO blood group on disease recurrence and progression in bladder carcinoma. Material and methods: Patients with bladder carcinoma undergoing transurethral resection of bladder tumor (TURBT) were studied prospectively for at least 1-year follow-up for recurrence and progression of the disease. Demographic profile along with blood group was noted. Results: Two hundred patients were included in the study and 194 patients were included in the final analysis. Muscle-invasive bladder cancer was present in 39 (20.1%) patients and the high-grade tumor was present in 88 (45.3%) patients. There was no statistical significance between the association of blood grouping and grade ( p=0.29) and stage of the disease ( p=0.20). During the follow-up period, there were 100 (64.5%) recurrences and 15 (9.7%) patients with non-muscle-invasive bladder carcinoma had progression. The association of blood group with recurrence ( p=0.66) and progression ( p=0.11) of disease was not statistically significant. Conclusion: There is no association between bladder cancer and ABO blood group in terms of grade and stage of the disease. The recurrence and progression of the disease did not differ significantly in different blood groups. Level of Evidence: 2b

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Do blood groups have effect on prognosis of patients undergoing radical cystectomy?

Abstract: ABO blood group and Rh factor were not associated with the prognosis of bladder cancer patients who underwent radical cystectomy. However, prospective studies are needed in larger patient series for further evaluations.

Cited by 12 publications

References 22 publications

ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity

ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity

A systematic review of prognosis of ABO blood group and rhesus factor on outcomes in patients with bladder cancer

The relationship between ABO blood group type and tumor grade, stage, recurrence and progression in transitional cell carcinoma of the bladder: A preliminary report

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