Do calcium supplements increase serum and urine calcium levels in post-menopausal women?

Samozai, Malika Noorjehan; Kulkarni, Ashok K.

doi:10.1007/s12603-014-0532-2

Cited by 12 publications

(10 citation statements)

References 16 publications

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“…[41] Moreover, several studies’ findings of the lack of correlation between calcium supplements and serum calcium levels suggest that the intake of calcium supplements (administered either via food or medication) may not always influence serum calcium levels. [42] In addition, no information on medication was available, which may have biased the observed association. Fourth, we used single values of serum markers, which are less accurate than using the means of several measures, and we did not measure ionized calcium levels, which is the gold standard.…”

Section: Discussionmentioning

confidence: 99%

Association of serum calcium concentrations with fibrinogen and homocysteine in nondiabetic Korean subjects

et al. 2016

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Considerable evidence shows that increased serum calcium levels are associated with metabolic disorders, cardiovascular disease, and increased mortality. This study investigated whether serum calcium, within a normal range, is significantly associated with serum fibrinogen and homocysteine, markers of increased cardiovascular disease risk in nondiabetic Korean subjects.A cross-sectional analysis was performed on 1096 subjects (mean age, 55.1 ± 11.1 years; 36.1% women) undergoing a general health checkup. Serum biochemistry was analyzed including serum albumin-corrected calcium (Cac), insulin resistance (IR, using homeostasis model assessment [HOMA]), fibrinogen, and homocysteine.Compared with patients within the lowest Cac quartile, those with higher Cac levels had increased fibrinogen and homocysteine levels as well as an increased proportion of smoking, dyslipidemia, and HOMA-IR. Correlation analyses revealed linear relationships for Cac with fibrinogen and homocysteine in both genders. After adjustment for confounding factors, serum Cac was significantly associated with high fibrinogen (odds ratio [OR] for the highest vs the lowest quartile = 1.76, 95% confidence interval [CI] = 1.09–2.83, P = 0.02) and homocysteine (OR = 1.83, 95% CI = 1.07–3.11, P = 0.027). Multivariate regression models showed that Cac was linearly associated with fibrinogen (standardized β = 0.14, P < 0.001) and homocysteine (standardized β = 0.07, P = 0.009).High normal calcium concentrations were independently associated with increased levels of fibrinogen and homocysteine. Further investigation is needed to validate whether slightly increased calcium levels within the normal range indicate a higher risk of cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Association of serum calcium concentrations with fibrinogen and homocysteine in nondiabetic Korean subjects

et al. 2016

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“…The changes in hormones and age-related degeneration in physical function might impact the body's reaction to some nutrients [54,56]. Studies showed that serum calcium were lower in postmenopausal women than in pre-menopausal women and calcium supplements increase urinary calcium more than the calcium in serum among postmenopausal women [57][58][59][60]. We think these differences may partly explain the different associations of DDS with fracture between age groups in this study.…”

Section: Discussionmentioning

confidence: 78%

Dietary Diversity and the Risk of Fracture in Adults: A Prospective Study

2020

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Nutrition plays an important and modifiable role in bone health. This study aimed to investigate the effect of dietary diversity on the risk of any type of fracture in adults. Data from the China Health and Nutrition Survey collected between waves 1997 and 2015 were used. A total of 10,192 adults aged 40 years and older were included in the analysis. Both dietary diversity score (DDS) based on Chinese dietary guidelines (DDS-CDG) and minimum dietary diversity for women (DDS-MDD-W) were computed. Cox proportional hazards regression models were conducted to determine the association. Stratified analyses were conducted in women by the age of fracture using the case-control study approach. In men, higher scores in both the DDS-CDG (hazard ratio (HR) 0.70, 95% CI 0.56–0.88) and DDS-MDD-W (HR 0.67, 95% CI 0.54–0.82) were associated with decreased risk of fracture, however, the associations were not significant in women (DDS-CDG: HR 0.94, 95% CI 0.79–1.12; DDS-MDD-W: HR 0.93, 95% CI 0.79–1.09). In the stratified analyses, higher DDS-CDG (odds ratio (OR) 0.74, 95% CI 0.58–0.95) and higher DDS-MDD-W (OR 0.76, 95% CI 0.60–0.95) were associated with lower risks of fracture in women aged 40 to 60 years; in women aged over 60 years, no association was observed (DDS-CDG: OR 1.10, 95% CI 0.83–1.46; DDS-MDD-W: OR 1.00, 95% CI 0.79–1.27). In summary, higher dietary diversity was associated with decreased risk of fracture in men and middle-aged women, but not in women aged over 60 years.

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“…Although calcium does play an essential role in apoptotic signaling pathways, 37 serum and extracellular fluid calcium levels are tightly regulated 38 and would not be meaningfully changed by modest CaD supplementation in an unselected population of older women. 39 The results of the current post hoc analysis of data from a large and well-executed RCT demonstrate a protective effect on hematologic malignancy incidence with modest vitamin D and calcium supplementation in older women. Considered in absolute terms, the size of the effect is not likely to be clinically significant, but may have public health relevance when considered at the population level.…”

Section: Discussionmentioning

confidence: 89%

“…For hematopoietic malignancies, it is less biologically plausible that calcium supplementation would affect carcinogenesis. Although calcium does play an essential role in apoptotic signaling pathways, serum and extracellular fluid calcium levels are tightly regulated and would not be meaningfully changed by modest CaD supplementation in an unselected population of older women …”

Section: Discussionmentioning

confidence: 99%

Incidence of hematologic malignancy and cause‐specific mortality in the Women's Health Initiative randomized controlled trial of calcium and vitamin D supplementation

Ammann

Drake

Haraldsson

et al. 2017

Cancer

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Background Prior evidence for a possible link between vitamin D status and hematologic malignancy (HM) in humans comes from observational studies, leaving unresolved the question of whether a true causal relationship exists. Methods We performed a secondary analysis of data from the Women’s Health Initiative (WHI) Calcium/Vitamin D (CaD) Trial, a large randomized controlled trial (RCT) of CaD supplementation compared to placebo in older women. Kaplan-Meier and Cox proportional hazards survival analysis methods were used to evaluate the relationship between treatment assignment and (a) incident HM and (b) HM-specific mortality over 10 years following randomization. HMs were classified by cell type (lymphoid, myeloid or plasma cell) and analyzed as distinct endpoints in secondary analyses. Results 34,763 WHI CaD trial participants (median age = 63 years) had complete baseline covariate data and were eligible for analysis. Women assigned to CaD had a significantly lower risk of incident HM (HR = 0.80, 95% CI: 0.65, 0.99) but not HM-specific mortality (in entire cohort: HR = 0.77, 95% CI: 0.53, 1.11; among incident HM cases following diagnosis: 1.03, 95% CI: 0.70, 1.51). In secondary analyses, protective associations were most robust for lymphoid malignancies, with HRs of 0.77 (95% CI: 0.59, 1.01) and 0.46 (95% CI: 0.24, 0.89) for cancer incidence and mortality in those assigned to CaD supplementation. Conclusions This post hoc analysis of data from a large and well-executed RCT demonstrates a protective association between modest CaD supplementation and HM risk in older women. Additional research on the relationship between vitamin D and HM is warranted.

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Do calcium supplements increase serum and urine calcium levels in post-menopausal women?

Abstract: Thus, the calcium supplements were of little significance on the serum calcium levels, but have a significant effect on the urinary calcium levels in post-menopausal women.

Cited by 12 publications

References 16 publications

Association of serum calcium concentrations with fibrinogen and homocysteine in nondiabetic Korean subjects

Association of serum calcium concentrations with fibrinogen and homocysteine in nondiabetic Korean subjects

Dietary Diversity and the Risk of Fracture in Adults: A Prospective Study

Incidence of hematologic malignancy and cause‐specific mortality in the Women's Health Initiative randomized controlled trial of calcium and vitamin D supplementation

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