Do changes in cigarette design influence the rise in adenocarcinoma of the lung?

Burns, David M.; Anderson, Christy M.; Gray, Nigel

doi:10.1007/s10552-010-9660-0

Cited by 65 publications

(54 citation statements)

References 27 publications

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“…The association of KTR with lung cancer risk was particularly prominent for cancers classified as SCC, and controlling for methionine in this subgroup had little impact on the OR estimates. This observation is intriguing because kynurenine is an endogenous ligand of AHR (16), which in turn mediates the metabolism of PAHs, including potent carcinogens that are specifically relevant in SCC development (26,27). The association of KTR with SCC cancers may therefore indicate activation of a pathway related to detoxification of environmental chemicals.…”

Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Chuang

Fanidi

Ueland

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Imbalances in tryptophan metabolism have been linked to cancer-related immune escape and implicated in several cancers, including lung cancer.Methods: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) that included 893 incident lung cancer cases and 1,748 matched controls. Circulating levels of tryptophan and six of its metabolites were measured and evaluated in relation to lung cancer risk.Results: Tryptophan (P trend ¼ 2 Â 10

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Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Chuang

Fanidi

Ueland

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…They should also be mentioned in the histological examination report. This to be noted that even if asbestos can be correlated with adenocarcinoma, cigarette smoking alone without any effect attributable to asbestos, may have caused the cancer as an efficient and decisive cause, and many authors in literature associate cigarette smoking with the onset of adenocarcinoma (25)(26)(27)(28)(29)(30)(31). The concentration is not absolutely suitable in that far below the current law TLV and therefore it is erroneous talking about continuous exposure to high doses of asbestos for over 35 years.…”

Section: © C I C E D I Z I O N I I N T E R N a Z I O N A L Imentioning

confidence: 99%

Exposure to asbestos and lung cancer: a case report

Caciari¹

2013

P.& R.

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SummaryIn Greek ¢μίaντοj (amiantos) means immaculate and incorruptible and ¥σβηστοj (asbestos) perpetual and inextinguishable. The knowledge of its particular characteristics and its applications dates back to ancient times; for example, Egyptians already used it for embalming. Industrial use of asbestos dates back to the late nineteenth century, following the discovery of large Canadian deposits in Quebec (1877). The later discovery of important deposits in South Africa (crocidolite, chrysotile, amosite), Russia (chrysotile), United States (chrysotile), Australia (crocidolite) and Finland (anthophyllite), Italy (chrysotile) favoured its spreading and use on a large scale. Asbestos has been a well known confirmed human carcinogen since 1992, but before that date it was widely and regularly used for its insulating properties and its resistance. Exposure to asbestos appears associated to several diseases, such as pulmonary fibrosis, asbestosis (characterized by typical lung lesions), and neoplasms such as pleural and peritoneal mesothelioma and pulmonary adenocarcinoma. To put the blame of a disease on exposure to asbestos, however, diagnostic criteria are needed, ranging from the discovery of asbestos fibers in lung parenchyma to an array of radio-immuno-histo-chemical findings, to the duration and extent of exposure, etc. Here is a case report of lung cancer attributed to exposure to asbestos, which reconstructs the history of the patient in a critical analysis of the diagnostic criteria. Data have been discussed in the light of the current knowledge, with the support of a scrupulous literary review, which lead us step by step along the evolution of our achievement about the carcinogenicity of asbestos. Mr. P (1932-2002) worked for a transport tramway company at the routine maintenance and repairs and died for lung adenocarcinoma. Scientific information worldwide produced about asbestos and its effects on human health are abundant, but it can't be assumed that what is now universally recognized and taken for granted was recognized and taken for granted and with the same diffusion in past years and in the years during which Mr. P worked (1955 1992). Hence, there is no certainty of the diagnosis of the lung primitive adenocarcinoma attributed to Mr. P because the diagnostic criteria suggested by the international literature have not been strictly applied. There are no clinical or instrumental or laboratory signs that can be considered as indicators of the effect of exposure to asbestos: pulmonary fibrosis, asbestosis, pleural plaques, asbestos fibers, asbestos corpuscles, and the hypotesis of a possible cause and effect relationship is not supported by valid data. KEY WORDS: asbestos, adenocarcinoma, cancerogenesis, TLV-TWA. BackgroundIn Greek ¢μίaντοj (amiantos) means immaculate and incorruptible and ¥σβηστοj (asbestos) perpetual and inextinguishable. The knowledge of its particular characteristics and its applications dates back to ancient Case report

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“…For example, filter vented American blend cigarettes produce higher levels of tobacco-specific nitrosamines (Gray et al, 2000;Hoffmann, Djordjevic, & Hoffmann, 1997). This and the deeper puffing have been linked to an increase in the incidence of adenocarcinoma that has occurred since their introduction (Burns, Anderson, & Gray, 2011a, 2011b.…”

Section: Evolution Of the Modern Cigarettementioning

confidence: 99%

Research Required for the Effective Implementation of the Framework Convention on Tobacco Control, Articles 9 and 10

Gray

Borland

2012

Nicotine & Tobacco Research

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This paper is part of a series of articles intended to set out the research questions that are relevant to the successful implementation of the various provisions of the Framework Convention on Tobacco Control (FCTC). This paper focuses on issues affecting Articles 9 and 10 of the FCTC. This paper focuses on the research that is most important for most countries, rather than on what is desirable in countries with high levels of research capacity.Articles 9 and 10 of the FCTC address the regulation of contents and emissions of tobacco products and regulation of tobacco product disclosure. Such regulation will be essential if the long-term objective of reducing the danger of tobacco products is to be achieved. There are many components of tobacco and tobacco smoke that are excessively toxic and dangerous to the user. Many of these components are carcinogenic and addictive and can be removed or reduced substantially with current known technology. The fact that these components remain in tobacco and tobacco smoke at levels that are unnecessarily dangerous is precisely the reason why the successful implementation of Articles 9 and 10 of the FCTC is important to tobacco control. This paper discusses the scientific challenges involved in successfully implementing Articles 9 and 10 of the FCTC, which focuses on regulating carcinogens and toxins in tobacco and tobacco smoke, the abuse liability of tobacco products, and the additives and engineering features in tobacco products that make tobacco products appealing to future consumers.The research issues we focus on are those required to support the early stages of regulation. As regulation proceeds, new and more sophisticated research questions will undoubtedly emerge.

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Do changes in cigarette design influence the rise in adenocarcinoma of the lung?

Cited by 65 publications

References 27 publications

Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

Exposure to asbestos and lung cancer: a case report

Research Required for the Effective Implementation of the Framework Convention on Tobacco Control, Articles 9 and 10

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