Do different doses of intravenous streptokinase alter the frequency of coronary reperfusion in acute myocardial infarction?

Gottlich, Charles M.; Cooper, Barry; Schumacher, John R.; Hillis, L. David

doi:10.1016/0002-9149(88)90880-6

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…However, this relationship was only found in those who received slow infusion rates of SK, which is consistent with the same findings on studies using urokinase [31]. Gottlich et al [32] described a prospective study in 56 patients in which the influence of three different dosages of SK (0.5, 0.75, and 1.5 MU) on time intervals from onset of pain to peak CPK and on the consumption of fibrinogen was measured. This study failed to demonstrate increasing efficacy with increasing dosages.…”

Section: Discussionsupporting

confidence: 82%

Efficacy of a New Accelerated Streptokinase Regime in Acute Myocardial Infarction: A Double Blind Randomized Clinical Trial

Ghaffari

Kazemi

Golzari

2011

Cardiovascular Therapeutics

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Section: Discussionsupporting

confidence: 82%

Efficacy of a New Accelerated Streptokinase Regime in Acute Myocardial Infarction: A Double Blind Randomized Clinical Trial

Ghaffari

Kazemi

Golzari

2011

Cardiovascular Therapeutics

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“…The mean time to peak CPK-MB in those re-perfused by this criterion in both the groups in combination was 9.04 hours compared with 11.6 hours in those not re-perfused. This observation and result of our study was comparable to that of Gottlich et al 11 There was a significant difference between the two groups with p-value of 0.031. This indicated that serum CPK-MB Levels peak earlier in the re-perfused than the non-reperfused group.…”

Section: Discussionsupporting

confidence: 92%

A Comparative Study of Efficacy of 7.5 Lakh Units Versus 1.5 Million Units of Streptokinase in Acute Myocardial Infarction in Elderly Patients

Kumar¹,

Bhagat²,

Jandyal³

2019

jemds

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BACKGROUND In developing countries like India, as the life expectancy has increased, more and more elderly patients having ischemic heart disease are being diagnosed and treated. We wanted to evaluate as to whether thrombolysis with a lower dose of 7.5 lakh units of streptokinase was as efficacious as with streptokinase in conventional doses of 1.5 million units in achieving reperfusion of the infarct related coronary artery. METHODS The present study was conducted in elderly patients aged more than 65 years over a period of one year from Nov. 2016 to Oct. 2017 at GMC, Jammu which is a tertiary care centre. Sixty elderly patients with acute myocardial infarction were enrolled in the study, presenting within 12 hours of onset of symptoms and having no contra-indication to thrombolytic therapy. RESULTS A total of 60 cases included in our study. The mean age of the patients in the study group (cases) was 69.33 ± 5.78 years, while that of control group was 69.00 ± 4.83 years. Majority of the patients (19) were observed to be in the age group of 70-75 years in the study as well as control group. In the study group (cases), 9 (30%) were females and 21 (70%) were males, while in the control group 5 (16.7%) were females and 25 (83.3%) were males. CONCLUSIONS Low dose (7.5 lakh units) of streptokinase was as effective as the standard dose (1.5 million units) of streptokinase in achieving reperfusion of the infarct related coronary artery, in the elderly patients of acute myocardial infarction.

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“…The major risk factor in both the groups was smoking, accounting for 60% (18 cases) and 66.67% (20 cases) in the study and the control group, respectively. This was followed by hypertension as a risk factor, comprising 53.33% (16 cases) and 46.67% (14) in the study and the control groups, respectively. No statistically significant difference was found between study and control groups regarding distribution of risk factors.…”

Section: Baseline Characteristicsmentioning

confidence: 86%

“…13 In a study taking time from streptokinase infusion to peak CPK as a criterion for reperfusion, it was found that peaking of CPK occurred at 9.7 ± 6.3 and 12.3 ± 4.8 hours in those receiving 7.5 lakh units and 1.5 million units of streptokinase, respectively (difference not statistically significant) [Gottlich et al]. 14 In this study, in the group receiving, 7, 50, 000 IU of streptokinase, 89%) patients showed peaking of CPK-MB within 12 hours, while 67% of patients did so in the group given 1.500, 000 IU. This compares well with the data of the present study.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

Post-Therapy Outcome and Echocardiographic Analysis at Three Weeks of Elderly Patients With Acute Myocardial Infarction Following Thrombolysis

Kumar¹,

Bhagat²,

Jandyal³

2019

jemds

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BACKGROUND Once severe ischemia has lasted for about 20 minutes, myocardial necrosis ensues, affecting the subendocardium first and then proceeding in a time dependent wave front to reach epicardium about 4 to 6 hours later. Restoration of blood flow before necrosis is transmural, arrests the progression of necrosis and salvages the still viable but ischemic myocardium that would otherwise proceed to necrosis. We wanted to assess the occurrence of complications of half dose of streptokinase versus full dose of streptokinase in three weeks follow-up following thrombolysis therapy. METHODS Sixty elderly patients with acute myocardial infarction were enrolled in the study, presenting within 12 hours of onset of symptoms and having no contra-indication to thrombolytic therapy at GMC, Jammu for a period of one-year w.e.f. Nov. 2017 to Oct. 2018. RESULTS Out of the total 60 cases included in our study, 30 (50%) were assigned to the study group and 30 (50%) were included in the control group. Overall, 46 (76.7%) males and 14 (23.3%) females were included in the study. CONCLUSIONS Low dose streptokinase also achieved post-therapy outcome comparable to the standard dose, as assessed clinically and echocardiographically in a short-term follow-up of three weeks. Also, low dose streptokinase (7.5 lakh units) infusion was found to be associated with a lower incidence of haemorrhagic complications as compared to conventional full dose (1.5 million units) streptokinase infusion.

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Do different doses of intravenous streptokinase alter the frequency of coronary reperfusion in acute myocardial infarction?

Cited by 10 publications

References 24 publications

Efficacy of a New Accelerated Streptokinase Regime in Acute Myocardial Infarction: A Double Blind Randomized Clinical Trial

Efficacy of a New Accelerated Streptokinase Regime in Acute Myocardial Infarction: A Double Blind Randomized Clinical Trial

A Comparative Study of Efficacy of 7.5 Lakh Units Versus 1.5 Million Units of Streptokinase in Acute Myocardial Infarction in Elderly Patients

Post-Therapy Outcome and Echocardiographic Analysis at Three Weeks of Elderly Patients With Acute Myocardial Infarction Following Thrombolysis

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