Do Drugs Acting on the Nervous System Affect Cell Proliferation in the Developing Brain

Lewis, Paul D.; Patel, Ambrish J.; Béndek, G.; Balázs, R.

doi:10.1016/s0140-6736(77)92607-1

Cited by 27 publications

(3 citation statements)

References 11 publications

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“…Rats were killed by decapitation so that the head dropped straight into liquid nitrogen. Snap-frozen forebrain and cerebellum were processed separately and other constituents were analysed as described previously (Patel et aZ., 1977 ;1977b).…”

Section: Biochemical Studiesmentioning

confidence: 99%

“…These effects on brain cell proliferation were regarded as being potentially of functional significance, because they could irreversibly deplete the affected cell population. This might result in significant and persistent alterations of brain circuitry and thereby of integrated brain function (Balks, Patel & Lewis, 1977;Lewis et al, 1977b;.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Haloperidol on Cell Proliferation in the Early Postnatal Rat Brain

Backhouse

Barochovsky

Malik

et al. 1982

Neuropathology Appl Neurobio

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Haloperidol, a widely used neuroleptic, produced a significant depression of the rate of [3H]thymidine incorporation into the DNA of 11-day-old rat brain. The reduction of in-vivo DNA synthesis rate was detectable by 4 h after subcutaneous injection of a single dose of haloperidol (20 mg/kg) and through the period 10-24 h after drug treatment the rate was less than 50% of that of controls in the forebrain. [3H]Thymidine incorporation returned to control values by 32 h. The effect on the cerebellum was similar but less pronounced. The depression was dose-dependent and a half-maximal effect was produced with haloperidol doses of 5-10 mg/kg. Parallel histological studies on treated rats suggested prolongation of the DNA synthesis phase of the cell cycle in the forebrain subependymal layer, associated with an increase in turnover time of about 15%.

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Section: Biochemical Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Haloperidol on Cell Proliferation in the Early Postnatal Rat Brain

Backhouse

Barochovsky

Malik

et al. 1982

Neuropathology Appl Neurobio

View full text Add to dashboard Cite

show abstract

“…Detection of nonstructural malformations is even more difficult, for very subtle anatomical and biochemical changes can induce functional abnormalities. Lewis et al (1977) have shown reserpine to interfere with cell proliferation in the brains of suckling rats, and long-term alterations in behaviour may be attributable to the effect of the drug. It is argued tha-t other compounds influencing central neurotransmitter activity may affect the developing brain.…”

mentioning

confidence: 99%