Do Epidermodysplasia Verruciformis Human Papillomaviruses Contribute to Malignant and Benign Epidermal Proliferations?

Majewski, Sławomir; Jabłońska, Stefania

doi:10.1001/archderm.138.5.649

Cited by 88 publications

(94 citation statements)

References 64 publications

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“…HPV 14, 17, 20 and 47 are less frequently found. 13,30,31 With the advancement of techniques for HPV identification and typing, HPV-EVs began to be detected not only in patients with the diagnosis of EV but also in normal skin and lesions of and immunocom- …”

Section: Epidermodysplasia Verruciformis (Ev)mentioning

confidence: 99%

Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas

Leto¹,

Júnior²,

Porro

et al. 2011

An. Bras. Dermatol.

113

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Human papillomavirus (HPV) is a DNA virus that presents tropism for epithelial cells, causing infections of the skin and mucous membranes. Replication of HPV occurs in the nuclei of squamous cells and its life cycle is directly related to the differentiation program of the host cell. To date, nearly 100 different types of HPV have been characterized and there is a large number of other types that have not been sequenced yet. Besides being responsible for benign lesions of the skin and mucous membranes, HPV is also involved in the development of various mucocutaneous tumors: Bowen's disease, non-melanoma skin cancers and genital carcinomas. This review discusses the characteristics of HPV, malignant and benign mucous and skin manifestations caused by HPV, besides the main methods of detection and typing of the virus. Keywords: DNA Viruses; Papillomavirus Infections; Warts Resumo: O papilomavírus humano (HPV) é um vírus DNA que apresenta tropismo por células epiteliais, causando infecções na pele e nas mucosas. A replicação do HPV ocorre no núcleo das células escamosas e o seu ciclo de vida é diretamente relacionado ao programa de diferenciação da célula hospedeira. Até o momento, foram completamente caracterizados cerca de 100 tipos diferentes de HPVs e há um grande número adicional de tipos ainda não sequenciados. Além de ser o responsável por lesões benignas de pele e mucosas, o HPV também está envolvido no desenvolvimento de diversos tumores cutaneomucosos: doença de Bowen, cânceres de pele não melanoma e carcinomas genitais. Esta revisão aborda as características do HPV, quadros cutâneos e mucosos benignos e malignos causados por ele e os principais métodos empregados em sua detecção e tipagem.

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Section: Epidermodysplasia Verruciformis (Ev)mentioning

confidence: 99%

Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas

Leto¹,

Júnior²,

Porro

et al. 2011

An. Bras. Dermatol.

113

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“…These HPV types are referred to as EV HPV types (also known as β-papillomaviruses) [3]. The most frequent EV HPV types are HPV type 5 and type 8 [4]. Uncontrolled HPV infections in EV patients result in flat warts and seborrheic-keratosis-like lesions arising during childhood or early adulthood.…”

Section: Introductionmentioning

confidence: 99%

Detection of Merkel Cell Polyomavirus in Epidermodysplasia-Verruciformis-Associated Skin Neoplasms

Mertz¹,

Schmid²,

Burger³

et al. 2010

Dermatology

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Background: Epidermodysplasia verruciformis (EV) is a rare genodermatosis that is characterized by susceptibility to infection with specific human papillomavirus (HPV) genotypes. Among polyomaviruses, the novel Merkel cell polyomavirus (MCPyV) has been found in different epithelial skin neoplasias. Objective: To examine whether EV is associated with cutaneous MCPyV infection. Methods: We used MCPyV-specific PCR to study skin neoplasms of 6 congenital EV patients and of 1 patient with acquired EV. Results: In all congenital EV patients, MCPyV DNA was found in carcinomas in situ, in invasive squamous cell carcinomas and in common warts. In 4 of these patients, the MCPyV-positive skin lesions were from different anatomic locations. In addition, 1 immunosuppressed patient suffering from acquired EV harbored MCPyV DNA in 2 common warts. In contrast, 7 normal skin samples tested negative for MCPyV DNA. Only 2 out of 24 carcinomas in situ (8.3%) and 2 out of 30 common warts (6.7%) from immunocompetent individuals were positive for MCPyV DNA. Conclusions: The strong association of EV-associated skin neoplasms with MCPyV suggests a unique susceptibility of EV patients to infections with MCPyV. Both MCPyV and EV-HPV may act as synergistic oncogenic cofactors in the development of EV-associated skin neoplasms.

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“…Recently, another large group of HPVs, the cutaneous epithelium-infecting betapapillomaviruses (betaHPVs), have gained more attention due to their possible involvement in cutaneous squamous cell carcinoma (SCC). HPV5 and HPV8 are the most prevalent betaHPV types and have been detected in 90% of cutaneous SCCs in epidermodysplasia verruciformis (EV) patients; however, a clear association between betaHPV infections and SCC has not been confirmed (2)(3)(4)(5).…”

mentioning

confidence: 99%

Mapping of Betapapillomavirus Human Papillomavirus 5 Transcription and Characterization of Viral-Genome Replication Function

Sankovski

Männik

Geimanen

et al. 2014

J Virol

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Do Epidermodysplasia Verruciformis Human Papillomaviruses Contribute to Malignant and Benign Epidermal Proliferations?

Cited by 88 publications

References 64 publications

Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas

Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas

Detection of Merkel Cell Polyomavirus in Epidermodysplasia-Verruciformis-Associated Skin Neoplasms

Mapping of Betapapillomavirus Human Papillomavirus 5 Transcription and Characterization of Viral-Genome Replication Function

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