(1) Although numerous articles have been published to address the drivers or barriers of corporate social responsibility (CSR), some parts of the world have received less attention. In this study, I reviewed the literature from 2010 to 2021 to identify drivers and barriers of CSR in the Middle East and North Africa (MENA) region and compare them with the findings in Western countries. (2) Methods: For this study, I used a structured literature review method. By setting the inclusion and exclusion criteria, only 28 articles remained from the selected database. (3) Results: The findings revealed that some CSR drivers, such as leadership styles, profitability, reputation, moral commitment, and environmental conservation, are common in both regions. There are also some differences between CSR drivers, for example, religious beliefs, low concentration of ownership, and company characteristics are some of the drivers in the MENA region. Maintaining social license to operate, and avoiding the risks of community opposition, pressure from the government, and consumer demand tend to be more important in Western countries. Common barriers in both regions are lack of financial resources, cost, lack of CSR knowledge and awareness, and ownership concentration. This review also highlighted that lack of law enforcement, lack of stakeholder communication, lack of management commitment, lack of interests, corruption, and financial debts are some of the barriers of CSR addressed in the MENA region, whereas cost/benefit ratio, lack of customer interest, and lack of scientific frameworks are special barriers in Western countries. (4) Conclusions: Although researchers in Western countries have more focus on the energy sector, there is a lack of research about the drivers and barriers of CSR in the MENA region in several industries, including oil and gas.