2007
DOI: 10.1097/jcp.0b013e3181515205
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Do Formulation Differences Alter Abuse Liability of Methylphenidate?

Abstract: The primary objective of this study was to determine if the abuse liability of methylphenidate is governed by formulation differences that affect rates of drug delivery. In this double-blind, placebo-controlled, randomized, crossover study, subjects with a history of recreational drug use received single oral doses of placebo, 60 mg of immediate-release methylphenidate (IR) and 108 mg of extended-release methylphenidate (osmotic release oral system [OROS]). Over 24 hours after dosing, blood was collected to de… Show more

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Cited by 66 publications
(21 citation statements)
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“…However, until a more acceptable and effective medication is available, there are few options available to clinicians to manage stimulant dependence. Extended-release formulations of agonist replacements (e.g., Concerta® or Dexedrine Spansule®) are available and should be considered until effective alternatives are identified, particularly because extended-release preparations are less likely to be misused [153, 154, 155]. …”
Section: Resultsmentioning
confidence: 99%
“…However, until a more acceptable and effective medication is available, there are few options available to clinicians to manage stimulant dependence. Extended-release formulations of agonist replacements (e.g., Concerta® or Dexedrine Spansule®) are available and should be considered until effective alternatives are identified, particularly because extended-release preparations are less likely to be misused [153, 154, 155]. …”
Section: Resultsmentioning
confidence: 99%
“…22,39 Increasing the rate of d-MPH absorption, 32,33,58,59 and consequently the rate of delivery to the central nervous system, 19,60,61 strongly influences the stimulatory effects underlying the reward value of MPH-ethanol co-abuse. 110 Accordingly, the PK and psychopharmacological findings reported here provide guidance for rational drug selection and individualization when treating ADHD with or without comorbid AUD.…”
Section: Discussionmentioning
confidence: 99%
“…21,32,33 However, the 50% IR-MPH component in the SODAS formulations represents the highest IR percent of any of the several existing MR-MPH products 34 and consequently results in a PK profile closely resembling the distinct dual plasma d-MPH concentration peaks of a typical twice daily IR-MPH regimen. 35,36 …”
Section: Introductionmentioning
confidence: 99%
“…Another important factor is the formulation of the medication. The reinforcing effects of stimulants are associated with rapid changes in serum concentration 39, and extended-release preparations of MPH are associated with less stimulant-like drug effects in healthy subjects 40. Of relevance to this specific psychiatric population is the fact that the OROS MPH is more difficult to use via a non-oral route (e.g.…”
Section: Discussionmentioning
confidence: 99%