Do heavy metals and metalloids influence the detoxification of organic xenobiotics in plants?

Schröder, Peter; Lyubenova, Lyudmila; Huber, Christian

doi:10.1007/s11356-009-0168-7

Cited by 53 publications

(29 citation statements)

References 21 publications

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“…52 Within ROS, H 2 O 2 acts as a second messenger to regulate the gene expression of some antioxidant enzymes in plant cells. 53 The extremely high content of H 2 O 2 in leaves exposed to 50 μM Cd may justify the decrease of some of the antioxidant enzyme activities observed.…”

Section: Chemical Research In Toxicologymentioning

confidence: 99%

Cadmium-Induced Cyto- and Genotoxicity are Organ-Dependent in Lettuce

Monteiro

Santos

Pinho

et al. 2012

Chem. Res. Toxicol.

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Cadmium is a priority pollutant. Its mechanisms and effects within different plant organs remain unclear. Here, cyto-genotoxicity biomarkers were evaluated in roots and leaves after Cd exposure (0, 1, 10, and 50 μM) of the model crop Lactuca sativa L. (cv. "Reine de Mai"). Overall, superoxide dismutase (SOD) and catalase (CAT) activities were stimulated in leaves, where Cd accumulation was lower in comparison to that in roots. In roots, SOD and peroxidase (POX, APX) activities were stimulated. Moreover, in both organs glutathione reductase (GR) was not affected by Cd. Overall, the H(2)O(2) content increased in both organs, while the total antioxidant capacity decreased in leaves and increased in roots with Cd concentrations. In both organs, lipid and protein oxidation rose with consequent increase of membrane permeability. Simultaneously, the comet assay showed that tail moment, tail length, and % tail DNA were maximum for 1 μM. For 10 μM, shorter tails were found suggesting induced Cd-DNA adducts that lead to DNA-DNA/DNA-protein cross-links, and/or formation of longer DNA fragments, and/or impairment of DNA repair mechanisms, while at 50 μM, nucleoids sensitivity to the technique was evident. This result was consistent with the maximum micronuclei frequency found for the 10 μM Cd dose in roots, suggesting that the surviving cells in this organ had an increase of mitotic catastrophe and that DNA repair systems for blocking cell cycle were dysfunctional. In lower Cd concentrations, root cells might have developed strategies to repair damaged DNA by blocking the cell cycle at specific checkpoints, thus avoiding mitotic catastrophe. Roots at 1 μM showed a cell cycle blockage trend at the G(2) checkpoint, while those at higher concentrations presented S phase delay. We finally discuss a general model of Cd-organ interaction covering these cyto- and genotoxic effects and the potential use of this cultivar in phytoremediation strategies.

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Section: Chemical Research In Toxicologymentioning

confidence: 99%

Cadmium-Induced Cyto- and Genotoxicity are Organ-Dependent in Lettuce

Monteiro

Santos

Pinho

et al. 2012

Chem. Res. Toxicol.

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“…In Cd-exposed P. australis, reduced GSH pool was advocated to protect the activity of many key photosynthetic enzymes against the thiophilic binding of Cd (Pietrini et al, 2003). However, the impact of a mixture of metals/metalloids was indicated by decreased concentrations of GSH and GSSG and the GSH:GSSG ratio in leaves and rhizomes of P. australis exposed to As (80 µM) + Cd (150 µM) + Pb (150 µM; Schroder et al, 2009). Salt marsh macrophyte Juncus maritimus performs major role of Hg phytostabilizer under environmental Hg exposure by restricting the entry of Hg accumulated at root level (Anjum et al, 2011(Anjum et al, , 2014a(Anjum et al, , 2015aMarques et al, 2011;Figueira et al, 2012).…”

Section: Biochemical Markers-role and Implication In Metal/metalloid-mentioning

confidence: 99%

“…Notably, severe impairments in the photosystem II (PS II) can be one of the first impacts (at biophysical level) caused by metal/metalloidaccrued elevations in the accumulation of light energy Santos et al, 2014). On the other hand, at biochemical level, metal/metalloid-accrued elevation in reactive oxygen species (ROS) in halophytic plant cells can cause imbalance in cellular redox homeostasis (Pietrini et al, 2003;Schroder et al, 2009;Gill and Tuteja, 2010;Li et al, 2011;Anjum et al, 2012aAnjum et al, ,b, 2014aAnjum et al, ,b,c, 2015aSantos et al, 2014Santos et al, , 2015. Despite above facts, discussion is meager in literature on the significance and important implications of major biophysical and biochemical markers in halophytes exposed to rapidly increasing metal/metalloid pollution.…”

Section: Introductionmentioning

confidence: 99%

Biophysical and Biochemical Markers of Metal/Metalloid-Impacts in Salt Marsh Halophytes and Their Implications

Anjum

Duarte

Sleimi

et al. 2016

Front. Environ. Sci.

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As a major sink, estuarine/salt marsh ecosystem can receive discharges laden with myriads of contaminants including metals/metalloids from man-made activities. Two among the major consequences of metal/metalloid-exposure in estuarine/salt marsh ecosystem flora such as halophytic plants are: (a) the excessive accumulation of light energy that in turn leads to severe impairments in the photosystem II (PS II), and (b) metal/metalloids-accrued elevation in the cellular reactive oxygen species (ROS) that causes imbalance in the cellular redox homeostasis. On one hand, plants adopt several strategies to dissipate excessive energy hence eventually to avoid damage in the PS II and maintain optimum photosynthesis. On the other hand, components of the cellular redox system quickly respond to metal/metalloid-exposure, where plants try to maintain a fine-tuning among these components, and tightly control the level of ROS and its potential consequences. Herein, major insights into, and the significance and implications of important biophysical and biochemical markers in metal/metalloid-exposed halophytes are overviewed and also highlighted main aspects so far least explored in the present context. Discussion advocates to regularly monitor and integrate studies on the highlighted herein biophysical and biochemical markers taking into account the missing aspects such as essential and non-essential metal/metalloid-speciation, -availability, and -methylation, role of the obvious microbial activities, and a comparative account of the outcomes of the studies on mixture of metal/metalloid performed in laboratory and field conditions. Thus, consideration of these missing aspects in future studies on the subject can help us to: (a) unveil the status of the metal/metalloid-contamination and -impact; (b) understand adaptive responses of salt marsh halophyte to metals/metalloids, and also (c) to devise sustainable strategies for the environmental or ecosystem management and safety.

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“…The kidney is a target for multiple xenobiotic toxicants, including potentially dangerous environmental chemicals and elements . The physiological, biochemical, and anatomical characteristics of the kidney make it particularly sensitive to environmental factors and chemical compounds . Those that contribute to the high sensitivity of the kidney include the presence of metabolizing enzymes and xenobiotic transporters, the concentration of a variety of solutes in the urine production process, and the significant blood flow in the organ .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies

et al. 2019

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Drug‐induced nephrotoxicity is a frequent serious adverse effect, contributing to morbidity and increased healthcare utilization. Prevention or reversal is key. Curcumin has useful biological features that include antioxidant, anti‐inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug‐induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in some animal models, human studies and clinical administration of curcumin for nephroprotection remains limited due to difficulty in achieving therapeutic levels following oral administration and in determining the optimal dosing schedule. Lack of sufficient evidence from animal studies, coupled with low systemic bioavailability, continues to limit the utilization of curcumin in addressing and controlling drug‐induced nephrotoxicity. Therefore, human studies are required to fully assess and validate the therapeutic potential of curcumin.

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Do heavy metals and metalloids influence the detoxification of organic xenobiotics in plants?

Cited by 53 publications

References 21 publications

Cadmium-Induced Cyto- and Genotoxicity are Organ-Dependent in Lettuce

Cadmium-Induced Cyto- and Genotoxicity are Organ-Dependent in Lettuce

Biophysical and Biochemical Markers of Metal/Metalloid-Impacts in Salt Marsh Halophytes and Their Implications

Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies

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