Do Infection Patterns of Human Papillomavirus Affect the Cytologic Detection of High-Grade Cervical Lesions on Papanicolaou Tests?

Samimi, Siavash Azadmanesh; Mody, Roxanne; Goodman, Steven; Luna, Eric; Armylagos, Donna; Schwartz, Mary R.; Mody, Dina R.; Ge, Yimin

doi:10.5858/arpa.2016-0478-oa

Cited by 14 publications

(17 citation statements)

References 23 publications

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“…The most recent interesting paper published by Samimi et al reported a problem with a cytological pattern detection of HPV infection. The authors concluded the HSIL cytological pattern might be obscured in cases of multigenotype hrHPV infection and in fact, true HSIL cases could mimic unequivocal Pap patterns (ASC-US, ASC-H, LSIL) [25]. In our cohort, we found only one biopsy, which confirmed Semimi's thesis.…”

Section: Discussionsupporting

confidence: 85%

HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion

Lewitowicz¹,

Nasierowska‐Guttmejer²,

Rokitaⴕ³

et al. 2020

aoms

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Introduction: Liquid-based cytology allows to apply modern and specific analyses of hrHPV genotyping in p16/Ki-67 test. All of these together could raise accuracy ratio for high-grade squamous intraepithelial lesion above 90%. The purpose of this study was to evaluate the diagnostic accuracy of LBC, hrHPV testing, and p16/Ki-67 testing in diagnosis of high-grade cervical intraepithelial lesions. Material and methods: The study consisted of 176 women, out of which 50 presented with HSIL (CIN2) SCC (cervical intraepithelial lesion grade 2 squamous cell carcinoma). 126 women with a negative Pap test were pooled into the second group of the study. All patients were resampled for LBC, HPV genotyping, and for the p16/Ki-67 test. The research was carried out between May and December 2017, and second sampling were taken from 1 to 4 months. Results: We reported a strong correlation between positive Pap test and hrHPV (p < 0.05) that met accuracy close to 90%. We noted correlations between a positive p16/Ki-67 with a positive Pap test: p

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Section: Discussionsupporting

confidence: 85%

HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion

Lewitowicz¹,

Nasierowska‐Guttmejer²,

Rokitaⴕ³

et al. 2020

aoms

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“…A study investigating detectability of biopsyconfirmed high-grade cervical lesions by pap-smear reported that false low-grade cytomorphology rates were higher in non-16/18 hrHPV and mixed hrHPV infected women than HPV 16/18 infected women. In light of this the authors suggested that diagnosis-treatment approach might be delayed due to increased pap test underdiagnosis rates (Samimi at al., 2018). Another problem is the lack of annual co-test follow-up compliance by patients.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Colposcopic Biopsy Results of Patients Who have Cytomorphological Normal but HPV 16-18 or Other High-Risk HPV Subtypes Positive

Aydoğmuş

2019

Asian Pac J Cancer Prev

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Objective:Current guidelines suggest annual co-test follow-up in non-16/18 high-risk HPV positive patients without abnormal cytologic findings. Considering the relatively high false-negative rates of cervical cytology, a follow-up period of one year might constitute an additional risk for development of cervical malignancies in these patients. The current study aims to evaluate colposcopic biopsy results of cytologically normal patients detected to carry high risk HPV by screening tests. Materials and Methods:A total of 160 patients with normal cervical cytology and high-risk HPV subtypes who underwent colposcopic examination were included in the study. Patients were divided into two groups according to their HPV results: HPV 16-18 and other types (non-16/18 high-risk subtypes). ECC, cervical biopsy, LEEP/conization results were analyzed for both groups. Histopathological results of the groups were compared in terms of ≤LSIL, HSIL and cervical cancer rates. Results:Cervical biopsy results in the “16-18” group were assessed as HSIL in 40 (48.2%) patients, LSIL in 6 patients (7.2%) and normal in 37 (44.6%) patients. ECC results revealed HSIL in 9 (10.8%) patients and LSIL in 1 (1.2%) patient. Nineteen out of 42 patients who underwent LEEP/conization had HSIL (surgical margin positivity was reported in 4 cases), while 3 patients had LSIL. None of the cases had cervical carcinoma.Conclusion:The present study detected that 15.6% of women infected with non-16/18 high-risk HPV subgroups developed ≥HSIL lesions. Although this rate seems lower than HPV 16-18 group, it is still too high to be overlooked. In conclusion, we suggest further clinical trials with larger number of patients to be conducted on this topic.

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“…Although data is limited and conflicting on this issue, it is possible that HPV 16 associated ≥CIN2 is more likely to be referred for colposcopy using standard management guidelines than is ≥CIN2 associated with other HPV genotypes [33,34]. ≥CIN2 lesions with HPV 16/18 are more likely accompanied by high-grade cytologic findings than ≥CIN2 lesions associated with other genotypes [35]. Moreover, lesion size is a determinant of the performance of both colposcopy and cervical biopsy; and HPV 16 associated ≥CIN2 lesions develop more rapidly than ≥CIN2 lesions associated with other HPV types [36,37].…”

Section: Discussionmentioning

confidence: 99%

HPV infections and cytologic abnormalities in vaccinated women 21–34 years of age: Results from the baseline phase of the Onclarity trial

Parvu

Stoler

Kodsi

et al. 2019

Gynecologic Oncology

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The impact of HPV vaccination was determined in a cervical cancer screening population from the USA-based, Onclarity Trial. • HPV and cytology testing were determined in 14,153 women, 21-34 years; and compared by vaccination status. • The prevalence of overall HPV, and genotypes 16, 18, 31, and 33/58 were significantly lower in vaccinated women. • Prevalence of ≥LSIL cytology (for any HPV result), and ≥CIN2 (only for HPV 16+ or 18+ cases), was lower in vaccinated women. • Data in this article suggest that "catch-up" vaccination provides benefit for adolescents and young adults.

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Do Infection Patterns of Human Papillomavirus Affect the Cytologic Detection of High-Grade Cervical Lesions on Papanicolaou Tests?

Cited by 14 publications

References 23 publications

HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion

HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion

Comparison of Colposcopic Biopsy Results of Patients Who have Cytomorphological Normal but HPV 16-18 or Other High-Risk HPV Subtypes Positive

HPV infections and cytologic abnormalities in vaccinated women 21–34 years of age: Results from the baseline phase of the Onclarity trial

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Do Infection Patterns of Human Papillomavirus Affect the Cytologic Detection of High-Grade Cervical Lesions on Papanicolaou Tests?

Cited by 14 publications

References 23 publications

HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion

HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion

Comparison of Colposcopic Biopsy Results of Patients Who have Cytomorphological Normal but HPV 16-18 or Other High-Risk HPV Subtypes Positive

HPV infections and cytologic abnormalities in vaccinated women 21–34 years of age: Results from the baseline phase of the Onclarity trial

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HPV infections and cytologic abnormalities in vaccinated women 21–34 years of age: Results from the baseline phase of the Onclarity trial