Do Intestinal Microbiota and Thyroid Travel in Tandem?

Merra, Giuseppe; Capacci, Annunziata; Lorenzo, Antonino De; Renzo, Laura Di; Gualtieri, Paola; Dri, Maria; Frank, Giulia; Marchetti, Marco

doi:10.33582/mpnfs.2022.202205001

Cited by 1 publication

(1 citation statement)

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“…Furthermore, it is well known how diet can affect the gut microbiota [20,21]. Higher levels of Granulicatella adiacens and Porphyromonas gingivalis, and lower levels of Streptococcus mitis and Neisseria elongata have been observed in PDAC patients, thus correlating with an increased risk of pancreatic cancer [22].…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Ductal Adenocarcinoma and Nutrition: Exploring the Role of Diet and Gut Health

Gualtieri,

Cianci,

Frank

et al. 2023

Nutrients

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The incidence of pancreatic cancer is increasing worldwide. The most common form is represented by pancreatic ductal adenocarcinoma (PDAC) which has been shown to be linked to chronic inflammation. Notably, the gut microbiota has emerged as a critical player in regulating immune responses and inflammation. Indeed, intestinal dysbiosis, characterized by an imbalance in the gut microbiota composition, can contribute to the initiation of chronic inflammation. Sterile chronic inflammation can occur, probably activated by the translocation of bacterial components, such as lipopolysaccharide (LPS), the major component of Gram-negative microbiota, with the consequent induction of innate mucosal immunity, through the activation of Toll-like receptors (TLRs). Furthermore, the interaction between LPS and TLRs could enhance cancer progression. Recent research has shed light on the pivotal role of nutrition, as a modifiable risk factor, in PDAC immunological processes, particularly focusing on the immuno-modulatory effects of the gut microbiota. Different dietary regimens, fiber intake, immunonutrients, and antioxidants have the potential to either exacerbate or mitigate chronic inflammation, thereby influencing the pathogenesis and natural history of PDAC. These dietary components may affect the gut microbiota composition and, consequently, the level of inflammation, either promoting or protecting against PDAC. In this review of reviews, we discuss the modulatory role of nutrition and the gut microbiota in PDAC’s immunological processes to explore a translational therapeutic approach that could improve the survival and quality of life of these patients.

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Section: Introductionmentioning

confidence: 99%