Do MCI patients with vitamin B12 deficiency have distinctive cognitive deficits?

Silva, Dina; Albers, Ulrike; Santana, Isabel; Vicente, Margarida; Martins, Isabel Pavão; Verdelho, Ana; Guerreiro, Manuela

doi:10.1186/1756-0500-6-357

Cited by 12 publications

(7 citation statements)

References 33 publications

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“…On the other hand, the prospective study conducted by Clarke et al [30] found that there was no association between cognitive decline (assessed with MMSE scores) and lower vitamin B12 levels. Previous studies have postulated that possessing the APOE 4 allele in combination with other factors, such as level of education or B vitamin deficiencies, might increase the risk of dementia [43,44]. APOE is an aggravating factor of the association between homocysteine and dementia [45].…”

Section: Discussionmentioning

confidence: 99%

Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis

Zhang

Luo

Yuan

et al. 2020

JAD

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Background: Previous studies have indicated that B vitamin deficiencies are an essential cause of neurological pathology. There is a need to provide evidence of the benefit of B vitamins for the prevention of cognitive decline in community-dwelling older adults. Objective: To examine the association between intake and plasma levels of vitamins B12, B6, and folate and cognitive function in older populations through a systematic review and meta-analysis. Methods: Medline (PubMed), EMBASE, and Cochrane databases were used to search the literature though August 8, 2019. We included observational population-based studies evaluating the association between concentrations or intake levels of vitamins B6, B12, or folate and cognition in older adults aged ≥45 years. The quality of all studies was assessed by the modified Newcastle-Ottawa Scale. Odds ratios (ORs) and hazard ratios (HRs) were analyzed by the random-effects model. Sensitivity analyses were conducted by excluding the studies with significant heterogeneity. Results: Twenty-one observational studies with sample sizes ranging from 155–7030 were included in the meta-analysis. Higher levels of vitamin B12 (OR = 0.77, 95% CI = 0.61–0.97) and folate concentration (OR = 0.68, 95% CI = 0.51–0.90) were associated with better cognition in cross-sectional studies, but not in sensitivity analyses or prospective studies. High vitamin B6 concentrations showed no significant benefit on cognition and dementia risk. Prospective studies did not provide substantial evidence for the relationship. Conclusion: The results from our meta-analysis suggest that vitamins B12, B6, and folate may not be modifiable risk factors for slowing cognitive decline among community-dwelling older individuals.

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Section: Discussionmentioning

confidence: 99%

Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis

Zhang

Luo

Yuan

et al. 2020

JAD

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“…It is known that a deficiency of this vitamin can be associated with a progressive atrophy of the brain and consequent cognitive decline 10 . Another study showed that in patients with MCI, low levels of this vitamin have not been associated with cognitive deficits, but its deficiency could precipitate the onset of symptoms 40 . Moore et al 41 concluded, after review of 43 studies on the subject, that vitamin B 12 deficiency may precede cognitive decline, but there is insufficient evidence to determine if this condition causes cognitive decline and neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with cognitive performance of non-demented elderly outpatients

Bueno

Belintani

Borim

et al. 2016

PAJAR, Pan Am. J. Aging Res.

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Objective: To evaluate the cognitive performance of non-demented elderly and its relation to sociodemographic, clinical and biochemical variables. Methods: 71 subjects (≥ 60 years) were studied. Sociodemographic data were collected in interviews; MMEM was used to assess cognition, the clinical variables were taken from the patient's medical record, and biochemical measurements were taken through blood tests which measured serum levels of vitamin B 12 , TSH and CrP. Results: Most of the subjects were women, older than 80 years old, with education between 1 and 4 years. Most of them had no diagnosis of diabetes mellitus, dyslipidemia, thyroid dysfunction or osteoporosis, and had their blood levels within the normal range; hypertension was present in 81% of patients. The average MMSE showed significant relation to gender, education and dyslipidemia; the presence of this diagnosis was related to better cognitive performance. Conclusion: This study suggests that elderly monitored by specialized health service can receive treatment for managing symptoms of morbidity and comorbidities, controlling, among others, cardiovascular risk factors, thus protecting them from suffering cognitive loss.

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“…The vast majority of patients with vitamin B12 deficiency in our clinic had B12 levels of 203-270 pg/mL, and most of them had no obvious complaints. Patients with vitamin B12 levels below 203 pg/mL were considered as having vitamin B12 deficiency 14 . Values below 135.4 pg/mL represented a serious deficiency.…”

Section: Discussionmentioning

confidence: 99%

“…The patient complaints included forgetfulness, loss of balance, numbness, and tingling and burning in hands and feet. Patients with serum B12 levels less than 200 pg/mL were considered as having vitamin B12 deficiency; patients with serum levels equal or higher than 200 pg/mL were considered normal 14 .…”

Section: Methodsmentioning

confidence: 99%

B12 Vitamin Eksikliği Olan Hastalarda Kobalamin Tedavisi Öncesi ve Sonrası Ortalama Trombosit Volümünün Değerlendirilmesi

Yüce¹,

Cüre²,

Cüre³

et al. 2014

Cukurova Medical Journal

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Purpose: Megaloblastic anemia due to vitamin B12 deficiency is common in the population. Vitamin B12 therapy may stimulate all cell types in the bone marrow. We investigated whether young, active and large platelets are released into the peripheral blood during vitamin B12 treatment and measured the level of mean platelet volume (MPV), an indicator of the presence of these platelets. Materials and Methods: A total of 204 patients (40 males, 160 females) with vitamin B12 deficiency were included in this study. Cobalamin was administered by intramuscular injections. We evaluated the hematologic and biochemical parameters before and after one month of vitamin B12 treatment. Results: The mean age of patients was 40.1 ± 17.4 years. In the pretreatment group, the mean level of vitamin B12 was 151.2 ± 34.6 pg/mL, the MPV was 7.8 ± 1.4 fL. In the posttreatment group, the mean vitamin B12 level was 638 ± 608 pg/mL, the MPV was 8.3 ± 1.3 fL. The levels of vitamin B12 (P < 0.001) and MPV (P < 0.001) were significantly higher in the posttreatment group than those in the pretreatment group. Conclusions: After one month of cobalamin treatment in patients with vitamin B12 deficiency, the levels of B12 and MPV were higher than the pretreatment levels. These results showed that vitamin B12 treatment may increases the release of large and active thrombocytes into the peripheral blood; therefore, caution may be needed in patients predisposed to thrombotic diseases. Key Words: Cobalamin, mean platelet volume, vitamin B12, vitamin B12 deficiency. ÖZETAmaç: B12 vitamin eksikliği toplumda sık görülen bir megaloblastik anemidir. B12 tedavisi kemik iliğindeki tüm serileri stimüle edebilir. Biz bu çalışmada B12 tedavisi sırasında periferik kana genç, aktif ve büyük trombositlerin salınıp salınmadığını ve bu trombositlerin varlığının iyi bir göstergesi olan ortalama trombosit hacmi (OTH) seviyesini araştırmayı amaçladık. ve OTH 7.8 ± 1.4 fL idi. Tedavi sonrası grupta, B12 vitamin seviyeleri 638 ± 608 pg/mL ve OTH 8.3 ± 1.3 idi. Tedavi sonrası grupta B12 vitamin (P < 0.001) ve OTH (P < 0.001) tedavi öncesi gruptan anlamlı yüksekti. Sonuç: B12 eksikliği olan hastalarda İM kobalamin tedavisinin 1. ayı sonunda tedavi öncesi değerlere göre B12 ve OTH değerinin arttığı MCV değerinin düştüğü bulundu. Çalışmamızın sonuçları gösterdi ki İM B12 tedavisi sırasında büyük ve aktif trombositler perifere daha çok salınabilir; trombotik hastalıklara yatkın olan hastalarda dikkatli olmak gerekebilir. Anahtar Kelimeler: Kobalamin, ortalama trombosit hacmi, B12 vitamini, B12 vitamin eksikliği.

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Do MCI patients with vitamin B12 deficiency have distinctive cognitive deficits?

Cited by 12 publications

References 33 publications

Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis

Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis

Factors associated with cognitive performance of non-demented elderly outpatients

B12 Vitamin Eksikliği Olan Hastalarda Kobalamin Tedavisi Öncesi ve Sonrası Ortalama Trombosit Volümünün Değerlendirilmesi

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