INTRODUCTION Validated conceptual frameworks are needed to guide interprofessional research in order to build a systematic body of knowledge of interprofessional collaborative practice (ICP). A conceptual framework derived from an extensive review of the interprofessional literature was developed. In the framework, constructs that include personal factors (i.e., beliefs in interprofessional collaboration, flexibility, trust, cooperation, and communication skills) and situational factors (i.e., leadership, empowerment, and support structures) are posited to influence effective ICP. ICP is conceptualized as understanding of roles, interdependence, knowledge exchange, and collective ownership of goals. Consequences of ICP include improved patient, organizational, and team and personal work behaviours and attitudes.