Do multivitamin supplements modify the relationship between prenatal alcohol intake and miscarriage?

Avalos, Lyndsay A.; Kaskutas, Lee Ann; Block, Gladys; Li, De-Kun

doi:10.1016/j.ajog.2009.07.059

Cited by 12 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Existing data has documented the possibility of multiple micronutrient supplements protecting against the negative effects of fetal alcohol exposure. Research in this area is preliminary, yet the data are compelling and demonstrate the possibility of micronutrient supplementation as having a critical role in preventing FAS (Ammon Avalos, Kaskutas, Block, & Li, 2009; Avalos, Kaskutas, Block, Abrams, & Li, 2011; Ballard, Sun, & Ko, 2012). It is possible that the administration of fortified foods and micronutrient capsules during prenatal care could prevent FAS.…”

Section: Discussionmentioning

confidence: 99%

Food Insecurity and Alcohol Use Among Pregnant Women at Alcohol-Serving Establishments in South Africa

et al. 2013

View full text Add to dashboard Cite

OBJECTIVE South Africa has the highest rate of fetal alcohol syndrome (FAS) in the world. While efforts have been made to curb the high rate of FAS, little is known about situational factors that may contribute to alcohol use during pregnancy. In the current paper, we focus on the role of food insecurity and its relationship to alcohol use among pregnant women. DESIGN Women completed computed assisted interviews. Generalized linear modeling was used in all analyses. SETTING Women attending alcohol serving establishments in a township in Cape Town, South Africa were recruited for the study. PARTICIPANTS Five hundred sixty women were sampled and 95 women reported being pregnant. RESULTS High levels of alcohol use were reported among pregnant women: 65% of women consumed alcohol at least every month and 29% consumed alcohol as often as two to three times per week. Thirty four percent of the women reported having 6 or more drinks per occasion on at least a weekly basis. The majority (87%) of pregnant women reported experiencing some form of food insecurity (e.g. food unavailable, eating less) in the past month. Alcohol use was significantly associated with food insecurity, even when controlling for relevant demographic variables. CONCLUSIONS Intervention with pregnant women who consume alcohol is urgently needed. Future research should focus on understanding the intersection of food insecurity and alcohol, and how the experience of food insecurity may contribute to greater rates of alcohol use and abuse among pregnant women.

show abstract

Section: Discussionmentioning

confidence: 99%

Food Insecurity and Alcohol Use Among Pregnant Women at Alcohol-Serving Establishments in South Africa

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Women who were more likely to drink alcohol were less likely to take multivitamin supplements in the periconceptional period. Two studies have reported that multivitamin supplementation in early pregnancy reduced the risk of preterm and small-for-gestational-age births (Avalos et al, 2011) and miscarriage (Ammon Avalos et al, 2009) among alcohol users. However, this study is the first of which we are aware that has explored associations between multivitamin use and alcohol consumption in women during the periconceptual period.…”

Section: Discussionmentioning

confidence: 99%

“…As embryonic development begins at conception, before most women are aware of their pregnancy, the benefits of multivitamin supplementation can best be obtained by supplementation that is initiated in the period prior to pregnancy (CDC, 2004; Wolff et al, 2009). However, surveys show that less than half of childbearing-aged women (Ammon Avalos et al, 2009; Kim et al, 2011; Sullivan et al, 2009) and less than one-third of women in the month prior to pregnancy (CDC, 2004; Yu et al, 1996) use multivitamin supplements.…”

mentioning

confidence: 99%

“…Two studies have shown that multivitamin supplement use during early pregnancy may modify the risks of small-for-gestational-age, preterm birth (Avalos et al, 2011), and miscarriage (Ammon Avalos et al, 2009) associated with low-to-moderate alcohol intake; however, no studies to our knowledge have investigated dose–response associations between alcohol consumption and multivitamin supplement use before pregnancy. Therefore, we explored associations between periconceptional alcohol use (drinking and “binge” or heavy episodic drinking) and multivitamin supplementation use in participants from Pregnancy Risk Assessment and Monitoring System (PRAMS).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Associations Between Multivitamin Supplement Use and Alcohol Consumption Before Pregnancy: Pregnancy Risk Assessment Monitoring System, 2004 to 2008

Weiss

Chambers

2013

Alcohol Clin Exp Res

View full text Add to dashboard Cite

Background Approximately 50 to 70% of childbearing-aged women consume alcohol and up to 23% of pregnancies have some level of prenatal alcohol exposure. Methods Using data from the Pregnancy Risk Assessment Monitoring System from 2004 to 2008, 111,644 women who completed questions relating to periconceptional alcohol use and multivitamin supplement use were included in the study. This study explored associations between periconceptional alcohol use and multivitamin supplementation use. Weighted multivariable logistic regression was used to explore associations, adjusting for maternal education, maternal ethnicity, maternal age, household income, and parity. Results During the periconceptional period, a dose-dependent association was found where women who consumed alcohol (≤ 3 drinks/wk, odds ratio [OR] = 0.76; 4 to 6 drinks/wk, OR = 0.60; 7 to 13 drinks/wk, OR = 0.49; ≥ 14 drinks/wk, OR = 0.39) and binged on alcohol (1 time, OR = 0.76; 2 to 3 times, OR = 0.66; 4 to 5 times, OR = 0.56; ≥ 6 times, OR = 0.50) were significantly less likely to take a multivitamin supplement compared with those that did not consume alcohol. Conclusions These findings emphasize the importance of periconceptional multivitamin supplement use, especially among alcohol-consuming women of childbearing age.

show abstract

“…Further potential confounders collected as repeated measures across all questionnaires include maternal psychological wellbeing, [26–30] smoking, [28, 31, 32] illicit substances, [27, 33] medication and supplement use, particularly folate [14, 34]. Several factors are measured in Q4 (at 12 months after birth), providing proxy measures for unknown antecedent confounding factors.…”

Section: Methodsmentioning

confidence: 99%

Study protocol: Asking QUestions about Alcohol in pregnancy (AQUA): a longitudinal cohort study of fetal effects of low to moderate alcohol exposure

Muggli

O’Leary

Forster

et al. 2014

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundDespite extensive research, a direct correlation between low to moderate prenatal alcohol exposure (PAE) and Fetal Alcohol Spectrum Disorders has been elusive. Conflicting results are attributed to a lack of accurate and detailed data on PAE and incomplete information on contributing factors. The public health effectiveness of policies recommending complete abstinence from alcohol during pregnancy is challenged by the high frequency of unplanned pregnancies, where many women consumed some alcohol prior to pregnancy recognition. There is a need for research evidence emphasizing timing and dosage of PAE and its effects on child development.Methods/DesignAsking QUestions about Alcohol (AQUA) is a longitudinal cohort aiming to clarify the complex effects of low to moderate PAE using specifically developed and tested questions incorporating dose, pattern and timing of exposure. From 2011, 2146 pregnant women completed a questionnaire at 8-18 weeks of pregnancy. Further prenatal data collection took place via a questionnaire at 26-28 weeks and 35 weeks gestation. Extensive information was obtained on a large number of risk factors to assist in understanding the heterogeneous nature of PAE effects. 1571 women (73%) completed all three pregnancy questionnaires. A biobank of DNA from maternal and infant buccal cells, placental biopsies and cord blood mononuclear cells will be used to examine epigenetic state at birth as well as genetic factors in the mother and child. Participants will be followed up at 12 and 24 months after birth to assess child health and measure infant behavioural and sensory difficulties, as well as family environment and parenting styles. A subgroup of the cohort will have 3D facial photography of their child at 12 months and a comprehensive developmental assessment (Bayley Scales of Infant & Toddler Development, Bayley-III) at two years of age.DiscussionUsing detailed, prospective methods of data collection, the AQUA study will comprehensively examine the effects of low to moderate alcohol consumption throughout pregnancy on child health and development, including the role of key mediators and confounders. These data will ultimately contribute to policy review and development, health professional education and information about alcohol consumption for pregnant women in the future.

show abstract

Do multivitamin supplements modify the relationship between prenatal alcohol intake and miscarriage?

Cited by 12 publications

References 43 publications

Food Insecurity and Alcohol Use Among Pregnant Women at Alcohol-Serving Establishments in South Africa

Food Insecurity and Alcohol Use Among Pregnant Women at Alcohol-Serving Establishments in South Africa

Associations Between Multivitamin Supplement Use and Alcohol Consumption Before Pregnancy: Pregnancy Risk Assessment Monitoring System, 2004 to 2008

Study protocol: Asking QUestions about Alcohol in pregnancy (AQUA): a longitudinal cohort study of fetal effects of low to moderate alcohol exposure

Contact Info

Product

Resources

About