Do new and old biomarkers of early undifferentiated arthritis correlate with Arthritis Impact Measurement Scales?

Bandinelli, Francesca; Benucci, Maurizio; Salaffi, Fausto; Manetti, Mirko; Infantino, María; Damiani, Arianna; Manfredi, Mariangela; Grossi, Valentina; Matucci, Alessandra; Gobbi, Francesca Li; Marin, Gabriella

doi:10.55563/clinexprheumatol/nqqx5k

Cited by 11 publications

(12 citation statements)

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“…TNF‐α induces other cytokines, such as IL‐6, IL‐8, and IL‐1, 65 and it has been considered to play a fundamental role in RA pathogenesis 66 . A high serum level of TNF‐α correlates with physical impairments in RA patients 16 . However, in our study, the detected levels of TNF‐α in the sera of RA patients were low.…”

Section: Discussioncontrasting

confidence: 58%

“…66 A high serum level of TNFα correlates with physical impairments in RA patients. 16 However, in our study, the detected levels of TNFα in the sera of RA patients were low. This might be explained by the fact that TNFα levels are significantly high in the synovial fluid of RA patients.…”

contrasting

confidence: 68%

“…Therefore, early detection of RA in asymptomatic patients has become a top research priority 15 . Cytokines and chemokines are pro‐inflammatory agents released in the synovia and sera of RA patients 16 . The detection of certain cytokines and/or chemokines has significant predictive power in patients not previously diagnosed with RA and without any apparent significant features of the rheumatoid disorder 17,18 …”

Section: Introductionmentioning

confidence: 99%

“…15 Cytokines and chemokines are pro-inflammatory agents released in the synovia and sera of RA patients. 16 The detection of certain cytokines and/or chemokines has significant predictive power in patients not previously diagnosed with RA and without any apparent significant features of the rheumatoid disorder. 17,18 A large body of literature has proposed interleukin (IL)-6, 19 IL-8, 20 IL-1β, 21 C-C motif chemokine ligand (CCL)-5, 22 and tumor necrosis factor (TNF)α 23 as important early RA detection markers with significant prediction values.…”

mentioning

confidence: 99%

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Assessment of IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL 5 levels in newly diagnosed Saudi patients with rheumatoid arthritis

Alturaiki

Alhamad

Alturaiqy³

et al. 2022

Int J of Rheum Dis

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Background Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which mainly affects small joints, occurs most commonly in middle‐aged adults, and can be fatal in severe cases. The exact etiology of RA remains unknown. However, uncontrolled expression of pro‐inflammatory cytokines and chemokines can contribute to the pathogenesis of RA. Aim In the current study, we assessed the potential of serum concentrations of interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α, IL‐8, and C‐C motif chemokine ligand (CCL)5 as early predictive markers for RA. Methods In addition to clinical examination, blood samples were collected from 100 Saudi patients recently diagnosed with early RA for basic and serological tests, including rheumatoid factor (RF), C‐reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Sera of 32 healthy individuals were used as controls. Specific enzyme‐linked immunosorbent assay was used to quantify the serum IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL5 levels in the samples. Results Our results indicated that RF, CRP, and ESR levels were higher in RA patients compared to controls. Furthermore, serum levels of IL‐1β, IL‐6, IL‐8, and CCL5, but not TNF‐α, significantly increased in RA patients compared to controls. Conclusion Overall, the findings suggested that IL‐1β, IL‐6, IL‐8, and CCL5 can be used as biomarkers in the early diagnosis of RA.

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Section: Discussioncontrasting

confidence: 58%

contrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Assessment of IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL 5 levels in newly diagnosed Saudi patients with rheumatoid arthritis

Alturaiki

Alhamad

Alturaiqy³

et al. 2022

Int J of Rheum Dis

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“…A response to the MRP had already been demonstrated by the ETN originator [ 28 ]. A correlation between MRP and disability in patients with undifferentiated early arthritis, in particular with the anxiety-related component, has recently been demonstrated [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Predicting Loss of Efficacy after Non-Medical Switching: Correlation between Circulating TNF-α Levels and SB4 in Etanercept to SB4 Switchers and Naïve Patients with Rheumatic Disease

Benucci

Damiani²,

Russo³

et al. 2022

JPM

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Background: We investigated how the non-medical switching (NMS) between Etanercept (ETN)/originator and SB4/biosimilar affects treatment efficacy in a rheumatic disease (RD) cohort, evaluating some laboratory parameters as loss of efficacy predictors after NMS. Methods: We enrolled 124 patients with RD (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis): 79 switchers from ETN/originator to SB4 and 45 naïve patients receiving SB4 (first biological treatment). At baseline, 6 (T1), and 12 months (T2), clinical and laboratory parameters were evaluated. Results: In naïve patients, TNF-α significantly increased at T1 in responders (NR) and non-responders (NNR). TNF-α was lower in NNR than in NR at T1 and T2. In NR and NNR, drug levels (DL) increased between T1 and T2. However, DLs were lower in NNR than in NR at T1 and T2. TNF-α was higher in switcher responders (SR) than in non-responders (SNR) at T1 and T2. In SNR, DLs were higher at baseline than in SR, but they decreased significantly at T1 and T2. Conclusions: We observed a decrease in DL and TNF-α levels after NMS in SNR. Moreover, in naïve patients, DL and TNF-α levels were higher in NR than in NNR. Monitoring DL and TNF-α levels may represent a future precision medicine approach to predict loss of efficacy after NMS.

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Depressive symptom as a risk factor for cirrhosis in patients with primary biliary cholangitis: Analysis based on Lasso‐logistic regression and decision tree models

Zhou,

Li,

Liu

et al. 2024

Brain and Behavior

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BackgroundDepressive symptoms are frequently observed in patients with primary biliary cholangitis (PBC). The role of depressive symptoms on cirrhosis has not been fully noticed in PBC. We aimed to establish a risk model for cirrhosis that took depressive symptoms into account.MethodsDepressive symptoms were assessed by the 17‐item Hamilton Depression Rating Scale (HAMD‐17). HAMD‐17 score was analyzed in relation to clinical parameters. Least absolute shrinkage and selection operator (Lasso)‐logistic regression and decision tree models were used to explore the effect of depressive symptoms on cirrhosis.ResultsThe rate of depressive symptom in patients with PBC (n = 162) was higher than in healthy controls (n = 180) (52.5% vs. 16.1%; p < .001). HAMD‐17 score was negatively associated with C4 levels and positively associated with levels of alkaline phosphatase (ALP), γ‐glutamyl transpeptidase (GGT), total bilirubin (TB), Immunoglobulin (Ig) G, and IgM (r = −0.162, 0.197, 0.355, 0.203, 0.182, 0.314, p < .05). In Lasso‐logistic regression analysis, HAMD‐17 score, human leukocyte antigen (HLA)‐DRB1*03:01 allele, age, ALP levels, and IgM levels (odds ratio [OR] = 1.087, 7.353, 1.075, 1.009, 1.005; p < 0.05) were independent risk factors for cirrhosis. Elevated HAMD‐17 score was also a discriminating factor for high risk of cirrhosis in patients with PBC in decision tree model.ConclusionsDepressive symptoms were associated with disease severity. Elevated HAMD‐17 score was a risk factor for cirrhosis in patients with PBC.

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Do new and old biomarkers of early undifferentiated arthritis correlate with Arthritis Impact Measurement Scales?

Cited by 11 publications

References 0 publications

Assessment of IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL 5 levels in newly diagnosed Saudi patients with rheumatoid arthritis

Assessment of IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL 5 levels in newly diagnosed Saudi patients with rheumatoid arthritis

Predicting Loss of Efficacy after Non-Medical Switching: Correlation between Circulating TNF-α Levels and SB4 in Etanercept to SB4 Switchers and Naïve Patients with Rheumatic Disease

Depressive symptom as a risk factor for cirrhosis in patients with primary biliary cholangitis: Analysis based on Lasso‐logistic regression and decision tree models

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