2024
DOI: 10.1007/s11914-023-00850-2
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Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing

Murad K. Nazzal,
Ashlyn J. Morris,
Reginald S. Parker
et al.

Abstract: Purpose of Review Fractures are a prominent form of traumatic injury and shall continue to be for the foreseeable future. While the inflammatory response and the cells of the bone marrow microenvironment play significant roles in fracture healing, the nervous system is also an important player in regulating bone healing. Recent Findings Considerable evidence demonstrates a role for nervous system regulation of fracture healing in a setting of traumatic inj… Show more

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Cited by 4 publications
(3 citation statements)
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“…The traditional methods of writing a review article were employed for the human-generated writing style [13,16,19]. Specifically, a comprehensive literature review was completed, and an outline of relevant topics was created to help guide the authors in organizing and focusing their review article.…”
Section: Human-generated and Written Review Articlesmentioning
confidence: 99%
See 1 more Smart Citation
“…The traditional methods of writing a review article were employed for the human-generated writing style [13,16,19]. Specifically, a comprehensive literature review was completed, and an outline of relevant topics was created to help guide the authors in organizing and focusing their review article.…”
Section: Human-generated and Written Review Articlesmentioning
confidence: 99%
“…(2) neural regulation of fracture healing [16][17][18]; and (3) COVID-19 and musculoskeletal health [19,20]. With this background, we hypothesized that the human paper would take the most time and require the fewest changes between the first and final drafts.…”
Section: Introductionmentioning
confidence: 99%
“…To test this possibility in scientific writing, we created an experiment to see if the current state of LLMs, and more specifically ChatGPT 4.0, would be able to increase the efficiency of writing scientific review articles. To accomplish this, we first identified 3 topics of importance to the musculoskeletal research field: (1) COVID-19 and musculoskeletal health [ 4 , 5 ]; (2) the intersection of Alzheimer’s disease and bone [ 6 8 ]; and (3) the neural regulation of fracture healing [ 9 11 ]. We then implemented 3 approaches to write the first draft of review articles on each topic: (1) human only; (2) ChatGPT 4.0 only (AI-only or AIO); and (3) a combination of approaches 1 and 2 (AI-assisted or AIA).…”
Section: Introductionmentioning
confidence: 99%