Do not miss rifampicin-induced thrombocytopenic purpura

Aujayeb, Avinash; Gutch, Manish; Jain, Nityanand; Singh, Amit

doi:10.1136/bcr.12.2011.5282

Cited by 11 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21 Currently available laboratory tests can identify the causative agent in patients for whom there is suspicion and clinical evidence of DITP, including rifampicin-induced thrombocytopenia. 22,23 However, the aetiology of DITP can be established when a prompt rise in platelets occurs with the discontinuation of the drug, while its reintroduction leads to a new drop in platelet count, as noted in this patient.…”

Section: Discussionmentioning

confidence: 82%

Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature

Koumpis

Papathanasiou

Papakonstantinou

et al. 2021

EMJ

View full text Add to dashboard Cite

Thrombocytopenia may be associated with a variety of conditions and risks depending on its severity, ranging from mild epistaxis to life-threating bleeding. Many drugs or herbal remedies can cause thrombocytopenia by either inhibiting platelet production and/or enhancing their destruction from the peripheral blood mediated via an immunological mechanism implicating drug-dependent antibodies. The latter entity is called drug-induced immune thrombocytopenia: a life-threatening, under-recognised condition, which is often a diagnostic challenge. Rifampicin is a widely used, well-tolerated, and effective bactericidal drug. Adverse events, except for gastrointestinal effects, headache, skin rash, and pruritus, are uncommon. The authors herein report on a patient with isolated thrombocytopenia with a recent medical history of brucellosis on rifampicin and doxycycline. Thrombocytopenia was proved to be rifampicin-induced. Also presented is a short review of the literature on this rare subject, which should be of great importance to clinicians.

show abstract

Section: Discussionmentioning

confidence: 82%

Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature

Koumpis

Papathanasiou

Papakonstantinou

et al. 2021

EMJ

View full text Add to dashboard Cite

show abstract

“…4,5 Gastrointestinal problems (nausea, vomiting, diarrhea, and abdominal pain), hepatotoxicity, drug eruption, flu syndrome, hemolytic anemia, and renal failure are common side effects of rifampicin, particularly during intermittent treatment, but thrombocytopenia is rare. 3,5,6 In this report, the patient received anti-leprosy treatment including rifampicin for the first two rounds. Both times, the patient developed thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Rifampicin-Induced Thrombocytopenia in a Patient with Borderline Lepromatous Leprosy

Shui

Shi

Jing

et al. 2020

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…5 Rifampicin is one of the most common antitubercular drug for the causation of thrombocytopenia by antibody-mediated platelet destruction mechanism. [7][8][9] Thrombocytopenia can occur with all first line antitubercular drugs (isoniazid, pyrazinamide, ethambutol, and rifampicin). Isoniazid causes thrombocytopenia in the form of hematological reaction where else other first line drugs like ethambutol and pyrazinamide by immunological mechanism.…”

Section: Discussionmentioning

confidence: 99%

Rifampicin induced acute thrombocytopenia with skin rashes: a case report

B.,

Babu

2023

Int J Adv Med

View full text Add to dashboard Cite

Rifampicin is an essential component of the treatment regimen for tuberculosis. Extensive clinical experience has shown that the drug has mild adverse effect, but on rare occasions, it can cause life threatening adverse reactions like thrombocytopenia. Blajchman et al first described rifampicin-induced thrombocytopenia in 1970. Since then, almost 40 cases have been documented in the literature and a recent review by Cooper and Ghanima included rifampicin in the group of not uncommon drugs that cause immune-mediated thrombocytopenia. Diagnosis of drug-induced immune thrombocytopenia is by identifying clinical symptoms and a careful evaluation of the suspected causative drug. The physician treating tuberculosis patients must be aware of this rare life-threatening complication, when we detected early, is completely reversible.

show abstract

Do not miss rifampicin-induced thrombocytopenic purpura

Cited by 11 publications

References 7 publications

Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature

Rifampicin-Induced Thrombocytopenia: A Case Report and Short Review of the Literature

Case Report: Rifampicin-Induced Thrombocytopenia in a Patient with Borderline Lepromatous Leprosy

Rifampicin induced acute thrombocytopenia with skin rashes: a case report

Contact Info

Product

Resources

About