Do opioids cause colic?

Liposomal bupivacaine is both safe and effective when administered via local infiltration at surgical site and mesovarium for laparoscopic ovariectomy in mares

“…The assignment to groups was accomplished by generating a random sequence of 12 letters (A, B, and C) corresponding to the three groups. These were then sealed into consecutively numbered envelopes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), and each case that was recruited was assigned the next numbered envelope. The three groups were (A) Group LB20-0.75% BHCl (30 ml) followed by LB 20 ml (266 mg), volume expanded to 80 ml with sterile saline (1:4 volume expansion), (B) Group LB40-0.75% BHCl (30 ml) followed by LB 40 ml (532 mg) volume expanded to 80 ml with sterile saline (1:2 volume expansion) or (C) Group BHCL-0.75% BHCl alone (70 ml).…”

“…While a combination of therapies is available to mitigate discomfort in equine patients (including NSAIDs, opioids, alpha-2-adrenergic agonists, gabapentin, and others), and indeed multimodal analgesic therapy with the above agents remain the cornerstone of appropriate pain management in horses, there remains a critical need to improve pain management in horses while minimising systemic adverse effects associated with the use of various other analgesic agents and decreasing the doses necessary for appropriate analgesia. 1,2 Local anaesthetics represent the only class of drugs that may be able to provide complete antinociception when administered appropriately while also having minimal systemic side effects following perineural administration or tissue infiltration. One of the main drawbacks of currently available local anaesthetics is their duration of action, which generally is no longer than 8-12 h. 3 Long-term delivery systems, such as wound infiltration catheters, have been investigated as a way to provide intermittent or continuous perineural nerve blockade for longerduration analgesia.…”

Liposomal bupivacaine provides longer duration analgesia than bupivacaine hydrochloride in an adjustable sole-pressure model of equine lameness

“…ing adverse effects on gastrointestinal motility, and opioids have become increasingly expensive and difficult to obtain for veterinary patients. 4 In addition, NSAIDs may also have clinically important side effects, including nephrotoxicity and right dorsal colitis. 5 Drugs that target neuropathic pain (eg, gabapentin) and multimodal treatments that use constant-rate infusions of lidocaine, ketamine, butorphanol, or morphine, alone or in combination, may be used as alternatives to treatment with NSAIDs for hospitalized cases.…”