Do Panic Symptom Profiles Influence Response to a Hypoxic Challenge in Patients With Panic Disorder? A Preliminary Report

Jg, Beck; Shipherd, Jillian C.; Ohtake, Patricia J.

doi:10.1097/00006842-200009000-00012

Cited by 31 publications

(19 citation statements)

References 15 publications

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“…Nevertheless, within this category there are diverse clinical presentations, leading to concerns that PD is not a singular diagnosis. 8 As a response to these concerns, alternative classification schemes have been devised. 8 Klein 6 postulated two PD subtypes: the respiratory subtype (RS), with prominent respiratory symptoms, probably linked to the false suffocation alarms; and the autonomic, with prominent peripheral autonomic symptoms such as palpitations.…”

Section: Introductionmentioning

confidence: 99%

Panic Disorder Respiratory Subtype: Psychopathology, Laboratory Challenge Tests, and Response to Treatment

Freire

Perna

Nardi

2010

Harvard Review of Psychiatry

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Section: Introductionmentioning

confidence: 99%

Panic Disorder Respiratory Subtype: Psychopathology, Laboratory Challenge Tests, and Response to Treatment

Freire

Perna

Nardi

2010

Harvard Review of Psychiatry

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“…It has been suggested that PD with respiratory symptoms differ from PD without respiratory symptoms (Klein 1993;Meuret et al 2006;Nardi et al 2008;Onur et al 2007), the respiratory subtypes being more sensitive to panic provocations in the laboratory with substances such as CO 2 and caffeine (Abrams et al 2006;Biber and Alkin 1999;Freire et al 2008;Nardi et al 2007;Nardi et al 2006), and showing respiratory irregularities to a greater extent than the non-respiratory subtype (Beck et al 2000;Bystritsky et al 2000).…”

Section: Panic Disorder and Respirationmentioning

confidence: 99%

Paroxetine influences respiration in rats: implications for the treatment of panic disorder

Olsson¹,

Annerbrink²,

Bengtsson³

et al. 2004

European Neuropsychopharmacology

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SwedenPrinted by Chalmers Reproservice, Göteborg, Sweden Previously published papers were reproduced with kind permission from the publishers. Background and aims: Panic disorder is a psychiatric disorder characterized by sudden attacks of intense anxiety. It displays a lot of features suggesting that it may be associated with an underlying aberration in the autonomic regulation of heart activity and respiration: i) the attacks are often characterized by respiratory symptoms and symptoms from the heart, ii) the attacks can be elicited by respiratory stimulants, iii) between attacks, patients with panic disorder often display enhanced respiratory variability and reduced heart rate variability, and iv) patients with panic disorder display enhanced prevalence of respiratory disorders and enhanced mortality in cardiovascular disease. Addressing the reasons for these physiological aberrations may help in elucidating the pathophysiology underlying panic disorder, and shed light on why this disorder is associated with enhanced mortality in cardiovascular disease. Serotonin is believed to be a neurotransmitter of great importance for panic disorder, as well as for the regulation of respiration: one main purpose of the animal studies presented in this thesis hence was to increase our knowledge regarding the role of serotonin in respiratory regulation, the hypothesis being that aberrations in respiration may cause the anxiety attacks, and that serotoninmodulating drugs may prevent panic attacks partly by stabilizing the regulation of respiration. In the first part of the thesis, data is presented on the effects on respiration in freely moving rats of various serotonergic compounds. The second part of this thesis is focused on genetic variations that may be associated with panic disorder. Orexin is a neuropeptide of suggested importance for both respiratory regulation and arousal. We investigated two polymorphisms in the orexin receptors 1 and 2, HCRTR1 Ile408Val and HCRTR2 Val308Iso, in panic disorder patients and healthy controls. Catechol-O-methyltransferase (COMT) is an enzyme that degrades catecholamines such as dopamine and noradrenaline, and may thus be of importance for both autonomic control and psychiatric symptoms. The functional Val158Met polymorphism in this gene has been associated with panic disorder in several studies; in an attempt to replicate this finding, we genotyped this polymorphism in the same group of panic disorder patients. In a separate cohort, we also explored if the same polymorphism is associated with risk factors for cardiovascular disease. Observations: 1) Serotonin depletion with para-chlorophenylalanine decreased respiratory rate and increased respiratory variability. 2) Chronic treatment with serotonin reuptake inhibitors increased respiratory rate. 3) Acute treatment with serotonin reuptake inhibitors, as well as the serotonin releasing drugs d-fenfluramine and m-CPP, and the 5-HT1A antagonist WAY-100635, decreased respiratory rate. 4) The HCRTR2 Val308Iso polymorphism was significantly...

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“…According to this classification system, panic disorder (PD) is a unitary diagnostic category 1 . Nevertheless, within this category there are diverse clinical presentations, leading to concerns that PD is not a singular diagnosis 2 . As a response to these concerns, alternative classification schemes have been devised 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, within this category there are diverse clinical presentations, leading to concerns that PD is not a singular diagnosis 2 . As a response to these concerns, alternative classification schemes have been devised 2 . Several studies indicated that PD patients with prominent respiratory symptoms may represent a distinct subtype of this disorder 3 .…”

Section: Introductionmentioning

confidence: 99%

Are patients with panic disorder respiratory subtype more vulnerable to tobacco, alcohol or illicit drug use?

Freire

Nardi

2013

Rev. psiquiatr. clín.

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Do Panic Symptom Profiles Influence Response to a Hypoxic Challenge in Patients With Panic Disorder? A Preliminary Report

Cited by 31 publications

References 15 publications

Panic Disorder Respiratory Subtype: Psychopathology, Laboratory Challenge Tests, and Response to Treatment

Panic Disorder Respiratory Subtype: Psychopathology, Laboratory Challenge Tests, and Response to Treatment

Paroxetine influences respiration in rats: implications for the treatment of panic disorder

Are patients with panic disorder respiratory subtype more vulnerable to tobacco, alcohol or illicit drug use?

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