Do Past Pain Events Systematically Impact Pain Ratings of Healthy Subjects or Fibromyalgia Patients?

Staud, Roland; Price, Donald D.

doi:10.1016/j.jpain.2009.06.014

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Here we characterize the somatosensory, psychological, neurological, and genetic abnormalities of a young child described by her parents as insensitive to pain since birth and compare her to her first‐degree family member and normal controls (NC). Her condition provided the unique opportunity to apply genetic as well as psychological and standardized psychophysical evaluations (Price, 1988; Price and Harkins, 1992; Staud et al, 2010; Price et al, 2008) to precisely characterize the abnormalities associated with her clinical condition. Normal pain‐free controls were used for comparisons.…”

Section: Introductionmentioning

confidence: 99%

Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

Staud

Price

Janicke

et al. 2011

European Journal of Pain

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Insensitivity to pain is a rare disorder that is commonly associated with Hereditary and Sensory Autonomic Neuropathies (HSAN I -V) resulting often in autonomic dysfunction and premature death. Very few individuals have been reported with pain insensitivity lacking such autonomic neuropathies. We performed genetic, neurologic, psychological, and psychophysical evaluations in such an individual (OMIM 243000) and her first degree relatives. Sequence analysis of genomic DNA revealed two novel SCN9A mutations in this index case (IC). One was a non-conservative missense mutation (C1719R) in exon 26 present only in the IC and one parent. Further sequence analysis of the child's DNA revealed a 1-bp splice donor deletion in intron 17 which was also present in the other parent and one sibling. Detailed psychophysical testing was used to phenotypically characterize the IC, her family members, and 10 matched normal controls. Similar to family members and controls the IC showed normal somatosensory functioning for nonnociceptive mechanoreception and warmth. However, she demonstrated diminished ability to detect cool temperatures combined with profound deficits in heat and mechanical nociception. Congenital insensitivity to pain in our IC was associated with two novel SCN9A mutations which most likely resulted in a Nav1.7 channelopathy. However, in contrast to individuals with other SCN9A mutations, the observed pain insensitivity was relative and not absolute, which may be consistent with hypomorphic effects of one or both mutations. The ability to sense at least some danger signals may be advantageous and ameliorate the otherwise increased morbidity and mortality of some individuals with congenital insensitivity to pain.

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Section: Introductionmentioning

confidence: 99%

Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

Staud

Price

Janicke

et al. 2011

European Journal of Pain

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“…The results, however, also yielded valuable "pain" insight into the life of a middle school student, which can/should be used to build future programs to continue this line of study. Past experiences powerfully influence future experiences and, in this study, having experienced pain more than 3 months powerfully predicted school attendance, PE attendance, recess attendance and sports participation [24,55]. Various studies have shown that school, PE, recess and sports participation/attendance have significant influences on various outcomes including drug use, teen-pregnancy, substance abuse, etc., down the road [7,56].…”

Section: Discussionmentioning

confidence: 55%

Behavior Change Following Pain Neuroscience Education in Middle Schools: A Public Health Trial

Louw

Landrus²,

Podolak

et al. 2020

IJERPH

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Chronic pain and the opioid epidemic need early, upstream interventions to aim at meaningful downstream behavioral changes. A recent pain neuroscience education (PNE) program was developed and tested for middle-school students to increase pain knowledge and promote healthier beliefs regarding pain. In this study, 668 seventh-grade middle-school students either received a PNE lecture (n = 220); usual curriculum school pain education (UC) (n = 198) or PNE followed by two booster (PNEBoost) sessions (n = 250). Prior to, immediately after and at six-month follow-up, pain knowledge and fear of physical activity was measured. Six months after the initial intervention school, physical education, recess and sports attendance/participation as well as healthcare choices for pain (doctor visits, rehabilitation visits and pain medication use) were measured. Students receiving PNEBoost used 30.6% less pain medication in the last 6 months compared to UC (p = 0.024). PNEBoost was superior to PNE for rehabilitation visits in students experiencing pain (p = 0.01) and UC for attending school in students who have experienced pain > 3 months (p = 0.004). In conclusion, PNEBoost yielded more positive behavioral results in middle school children at six-month follow-up than PNE and UC, including significant reduction in pain medication use.

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“…Likewise, current pain might have had little influence on the change in the appraisal of previous pain experiences in this study. In addition, another study showed that the association between past and current pain could be weak; only a small proportion (26.5%) of individuals without pain used past pain experiences in current pain appraisal (Staud et al, 2010). Contrary to the common assumption that a patient's report is an unreliable source of a pain experience (Marty et al, 2009;Dorfman et al, 2016), these results suggest that it is more accurate than expected, while the risk of being biased by contextual factors remains (Jensen et al, 2008;Boring et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Does past/current pain change pain experience? Comparing self-reports and pupillary responses

Yoo

Cho²,

Cho³

2023

Front. Psychol.

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IntroductionFor decades, a substantial body of research has confirmed the subjective nature of pain. Subjectivity seems to be integrated into the concept of pain but is often confined to self-reported pain. Although it seems likely that past and current pain experiences would interact and influence subjective pain reports, the influence of these factors has not been investigated in the context of physiological pain. The current study focused on exploring the influence of past/current pain on self-reporting and pupillary responses to pain.MethodsOverall, 47 participants were divided into two groups, a 4°C–10°C group (experiencing major pain first) and a 10°C–4°C group (experiencing minor pain first), and performed cold pressor tasks (CPT) twice for 30 s each. During the two rounds of CPT, participants reported their pain intensity, and their pupillary responses were measured. Subsequently, they reappraised their pain ratings in the first CPT session.ResultsSelf-reported pain showed a significant difference (4°C–10°C: p = 0.045; 10°C–4°C: p < 0.001) in the rating of cold pain stimuli in both groups, and this gap was higher in the 10°C–4°C group than in the 4°C–10°C group. In terms of pupillary response, the 4°C–10°C group exhibited a significant difference in pupil diameter, whereas this was marginally significant in the 10°C–4°C group (4°C–10°C: p < 0.001; 10°C–4°C: p = 0.062). There were no significant changes in self-reported pain after reappraisal in either group.DiscussionThe findings of the current study confirmed that subjective and physiological responses to pain can be altered by previous experiences of pain.

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Do Past Pain Events Systematically Impact Pain Ratings of Healthy Subjects or Fibromyalgia Patients?

Cited by 4 publications

References 22 publications

Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

Behavior Change Following Pain Neuroscience Education in Middle Schools: A Public Health Trial

Does past/current pain change pain experience? Comparing self-reports and pupillary responses

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