Do Pathophysiologic Mechanisms Linking Unhealthy Lifestyle to Cardiovascular Disease and Cancer Imply Shared Preventive Measures?　― A Critical Narrative Review ―

Fusco, Stefania Angela Di; Spinelli, Antonella; Castello, Lorenzo; Marino, G.; Maraschi, Ilaria; Gulizia, Michele Massimo; Gabrielli, Domenico; Colivicchi, Furio

doi:10.1253/circj.cj-21-0459

Cited by 4 publications

(2 citation statements)

References 79 publications

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“…6 The autophagic genes downregulated in the AF-LA (Figure 4C) included mechanistic target of rapamycin kinase (MTOR), which is important as the contributor of cell migration and DNA damage, 37,38 and the "brake" in autophagy. [39][40][41] This downregulation of MTOR in the AF-LA may suggest that autophagy was induced in AF-LA.…”

Section: Discussionmentioning

confidence: 87%

Transcriptome Discovery of Genes in the Three Phases of Autophagy That Are Upregulated During Atrial Fibrillation

et al. 2023

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Background: Autophagy may contribute to the maintenance of atrial fibrillation (AF), but no previous study has concurrently surveyed all 3 phases of autophagy, namely autophagosome formation, lysosome formation, and autophagosome-lysosome fusion. Here we aimed to identify disorders involving various phases of autophagy during AF. Methods and Results: We used bioinformatic techniques to analyze publicly available DNA microarray datasets from the left atrium (LA) and right atrium (RA) of 7 patients with AF and 6 patients with normal sinus rhythm who underwent valvular surgeries. We compared gene expression levels in the LA (AF-LA) and RA of patients with AF with those in the LA and RA of patients with normal sinus rhythm. Several differentially expressed genes in the AF-LA sample were significantly associated with the Gene Ontogeny term ‘Autophagy’, indicating that the expression of autophagic genes was specifically altered in this dataset. In particular, the expression of genes known or suspected to be involved in autophagosome formation (autophagy related 5 [ ATG5 ], autophagy related 10 [ ATG10 ], autophagy related 12 [ ATG12 ], and light chain 3B [ LC3B ]), lysosome formation (lysosomal associated membrane protein 1 [ LAMP1 ] and lysosomal associated membrane protein 2 [ LAMP2 ]), and autophagosome-lysosome fusion (synaptosome associated protein 29 [ SNAP29 ], SNAP associated protein [ SNAPIN ], and syntaxin 17 [ STX17 ]) was significantly upregulated in the LA-AF dataset. Conclusions: Autophagy is activated excessively in, and may perpetuate, AF.

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Section: Discussionmentioning

confidence: 87%

Transcriptome Discovery of Genes in the Three Phases of Autophagy That Are Upregulated During Atrial Fibrillation

et al. 2023

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“…Growing evidence of some common pathophysiologic mechanisms underlying cancer and cardiovascular disease (CVD) (7) (Table 1) has led to the development of "reverse cardiooncology" (24). The premise is that by addressing modifiable common risk factors it is possible to reduce the risk of both CVD and cancer (25). A prevention-oriented model of cardiooncology includes a pre-habilitation, habilitation and rehabilitation strategy to optimize physical fitness and cardiovascular health before, during and after cancer therapy, respectively (26)(27)(28).…”

Section: Cardiovascular Risk In Cancer Survivorsmentioning

confidence: 99%

Cancer survivorship at heart: a multidisciplinary cardio-oncology roadmap for healthcare professionals

Bisceglia,

Canale,

Silvestris

et al. 2023

Front. Cardiovasc. Med.

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In cancer, a patient is considered a survivor from the time of initial diagnosis until the end of life. With improvements in early diagnosis and treatment, the number of cancer survivors (CS) has grown considerably and includes: (1) Patients cured and free from cancer who may be at risk of late-onset cancer therapy-related cardiovascular toxicity (CTR-CVT); (2) Patients with long-term control of not-curable cancers in whom CTR-CVT may need to be addressed. This paper highlights the importance of the cancer care continuum, of a patient-centered approach and of a prevention-oriented policy. The ultimate goal is a personalized care of CS, achievable only through a multidisciplinary-guided survivorship care plan, one that replaces the fragmented management of current healthcare systems. Collaboration between oncologists and cardiologists is the pillar of a framework in which primary care providers and other specialists must be engaged and in which familial, social and environmental factors are also taken into account.

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Potential pathophysiologic mechanisms underlying the inherent risk of cancer in patients with atherosclerotic cardiovascular disease

Fusco¹,

Cianfrocca²,

Bisceglia³

et al. 2022

International Journal of Cardiology

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Do Pathophysiologic Mechanisms Linking Unhealthy Lifestyle to Cardiovascular Disease and Cancer Imply Shared Preventive Measures?　― A Critical Narrative Review ―

Cited by 4 publications

References 79 publications

Transcriptome Discovery of Genes in the Three Phases of Autophagy That Are Upregulated During Atrial Fibrillation

Transcriptome Discovery of Genes in the Three Phases of Autophagy That Are Upregulated During Atrial Fibrillation

Cancer survivorship at heart: a multidisciplinary cardio-oncology roadmap for healthcare professionals

Potential pathophysiologic mechanisms underlying the inherent risk of cancer in patients with atherosclerotic cardiovascular disease

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Do Pathophysiologic Mechanisms Linking Unhealthy Lifestyle to Cardiovascular Disease and Cancer Imply Shared Preventive Measures? ― A Critical Narrative Review ―

Cited by 4 publications

References 79 publications

Transcriptome Discovery of Genes in the Three Phases of Autophagy That Are Upregulated During Atrial Fibrillation

Transcriptome Discovery of Genes in the Three Phases of Autophagy That Are Upregulated During Atrial Fibrillation

Cancer survivorship at heart: a multidisciplinary cardio-oncology roadmap for healthcare professionals

Potential pathophysiologic mechanisms underlying the inherent risk of cancer in patients with atherosclerotic cardiovascular disease

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Product

Resources

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Do Pathophysiologic Mechanisms Linking Unhealthy Lifestyle to Cardiovascular Disease and Cancer Imply Shared Preventive Measures?　― A Critical Narrative Review ―